A0A011NUQ4 · A0A011NUQ4_9PROT

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site51-53substrate
Binding site60Zn2+ (UniProtKB | ChEBI)
Binding site64Zn2+ (UniProtKB | ChEBI)
Binding site64substrate
Binding site93-94substrate
Binding site119-121substrate
Binding site124substrate
Binding site174Zn2+ (UniProtKB | ChEBI)
Binding site174substrate
Binding site182Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase

Gene names

    • Name
      gmhA
    • ORF names
      AW10_02713

Organism names

Accessions

  • Primary accession
    A0A011NUQ4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain36-197SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    197
  • Mass (Da)
    20,688
  • Last updated
    2014-06-11 v1
  • MD5 Checksum
    AC74CACC7B8AF7A91E0EFD1905341EE2
MDLITRISQHFKDSAQTKLDAIEFLAAPIAQAIESMVACLLNNGKILACGNGGSAADAQHLAAELVGRFEAERHELAAIALTTDSSIMSAVANDYGFKMVFAKQVRALGQPGDVLVAISTSGNSPNVVEAINAAHENELRVVALTGKGGGAIGEMLRDGDVHISVPAERTARIQETHLLAIHCLCDGIDCLLMGVEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JEMX01000061
EMBL· GenBank· DDBJ
EXI79071.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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