A0A011MEP6 · A0A011MEP6_9PROT
- Protein4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
- GeneispG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids414 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Catalytic activity
- (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + oxidized [flavodoxin] + H2O + 2 H+ = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]
Cofactor
Note: Binds 1 [4Fe-4S] cluster.
Pathway
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 302 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 305 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 348 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
Binding site | 355 | [4Fe-4S] cluster (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity (ferredoxin) | |
Molecular Function | 4-hydroxy-3-methylbut-2-enyl-diphosphate synthase activity (flavodoxin) | |
Molecular Function | iron ion binding | |
Biological Process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway | |
Biological Process | terpenoid biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Candidatus Accumulibacter
Accessions
- Primary accessionA0A011MEP6
Proteomes
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length414
- Mass (Da)44,536
- Last updated2014-06-11 v1
- MD5 Checksum68865D70D0D81D55775C019C1DD4D8C3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JFAW01000050 EMBL· GenBank· DDBJ | EXI68283.1 EMBL· GenBank· DDBJ | Genomic DNA |