A0A009HJS2 · A0A009HJS2_ACIB9
- ProteinPqqA peptide cyclase
- GenepqqE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids384 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).
Catalytic activity
- [PQQ precursor protein] + S-adenosyl-L-methionine = E-Y cross-linked-[PQQ precursor protein] + 5'-deoxyadenosine + L-methionine + H+
Cofactor
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
Pathway
Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | cyclase activity | |
Molecular Function | iron ion binding | |
Molecular Function | oxidoreductase activity | |
Molecular Function | S-adenosyl-L-methionine binding | |
Biological Process | pyrroloquinoline quinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePqqA peptide cyclase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionA0A009HJS2
Proteomes
Interaction
Subunit
Interacts with PqqD. The interaction is necessary for activity of PqqE.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-220 | Radical SAM core | ||||
Sequence: VGLPLWLLAELTYRCPLQCPYCSNPLDYAQHKNELTTQEWFDVFDQARQMGAVQLGFSGGEPLVRQDLEQLVAHAHQLGFYTNLITSGMGLTEQRISHLKQAGLDHIQISFQASDPVVNDALAGSKHAFEQKYEMCRLVKKYDYPMVLNFVIHRHNIDQIDKIIELCLELNADTVELAICQFYGWAFLNRQGLLPTQEQLIRAERITNEYREKLKA |
Sequence similarities
Belongs to the radical SAM superfamily. PqqE family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length384
- Mass (Da)43,882
- Last updated2014-06-11 v1
- Checksum47EEDE74B6D99A03
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JEWH01000051 EMBL· GenBank· DDBJ | EXB04402.1 EMBL· GenBank· DDBJ | Genomic DNA |