A0A009HJS2 · A0A009HJS2_ACIB9

Function

function

Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; pyrroloquinoline quinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site19[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site23[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site26[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncyclase activity
Molecular Functioniron ion binding
Molecular Functionoxidoreductase activity
Molecular FunctionS-adenosyl-L-methionine binding
Biological Processpyrroloquinoline quinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    PqqA peptide cyclase
  • EC number
  • Alternative names
    • Coenzyme PQQ synthesis protein E

Gene names

    • Name
      pqqE
    • ORF names
      J512_3208

Organism names

  • Taxonomic identifier
  • Strain
    • 1295743
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A009HJS2

Proteomes

Interaction

Subunit

Interacts with PqqD. The interaction is necessary for activity of PqqE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-220Radical SAM core

Sequence similarities

Belongs to the radical SAM superfamily. PqqE family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    384
  • Mass (Da)
    43,882
  • Last updated
    2014-06-11 v1
  • Checksum
    47EEDE74B6D99A03
MTEGVGLPLWLLAELTYRCPLQCPYCSNPLDYAQHKNELTTQEWFDVFDQARQMGAVQLGFSGGEPLVRQDLEQLVAHAHQLGFYTNLITSGMGLTEQRISHLKQAGLDHIQISFQASDPVVNDALAGSKHAFEQKYEMCRLVKKYDYPMVLNFVIHRHNIDQIDKIIELCLELNADTVELAICQFYGWAFLNRQGLLPTQEQLIRAERITNEYREKLKAQNHPCKLIFVVPDYYEERPKACMNGWGKIFFTVAPDGMALPCHAARQLPISFPNVREQSLSKIWYESTGFNHFRGDAWMPEGCRSCPDKDRDFGGCRCQAYMLTGDASNADPVCGKSPYHQFIEQARAESEIDSSLEKLVFRNSRNSKQFTVQQNIPVQNIVDD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JEWH01000051
EMBL· GenBank· DDBJ
EXB04402.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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