A0A009HAD0 · A0A009HAD0_9GAMM

Function

function

Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondihydrofolate reductase activity
Molecular FunctionNADP binding
Biological Processdihydrofolate metabolic process
Biological Processfolic acid metabolic process
Biological Processone-carbon metabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate reductase
  • EC number

Gene names

    • ORF names
      J507_0454

Organism names

  • Taxonomic identifier
  • Strain
    • 1295259
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex

Accessions

  • Primary accession
    A0A009HAD0

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-169DHFR

Sequence similarities

Belongs to the dihydrofolate reductase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    169
  • Mass (Da)
    18,931
  • Last updated
    2014-06-11 v1
  • Checksum
    7BC48EE5B3B7F961
MAWQNVEVVHVVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVVMGRKTLESMGRALPNRVNWVITRDINWQFDGVKVAYSIEDALNAALEDVKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDLDVQGDAHYPTIPSEFHKTASEQHVDEKSGTSFEFATYKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JEWG01000003
EMBL· GenBank· DDBJ
EXB01037.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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