A0A009HAD0 · A0A009HAD0_9GAMM
- ProteinDihydrofolate reductase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids169 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
Catalytic activity
- (6S)-5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | dihydrofolate reductase activity | |
Molecular Function | NADP binding | |
Biological Process | dihydrofolate metabolic process | |
Biological Process | folic acid metabolic process | |
Biological Process | one-carbon metabolic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydrofolate reductase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter > Acinetobacter calcoaceticus/baumannii complex
Accessions
- Primary accessionA0A009HAD0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 7-169 | DHFR | ||||
Sequence: EVVHVVAMDKNHCIGKGNALPWHISADLKHFKEITQGGVVVMGRKTLESMGRALPNRVNWVITRDINWQFDGVKVAYSIEDALNAALEDVKNTEKQALFIIGGGEIFKQTLSIADRLELTHVDLDVQGDAHYPTIPSEFHKTASEQHVDEKSGTSFEFATYKK |
Sequence similarities
Belongs to the dihydrofolate reductase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length169
- Mass (Da)18,931
- Last updated2014-06-11 v1
- Checksum7BC48EE5B3B7F961
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JEWG01000003 EMBL· GenBank· DDBJ | EXB01037.1 EMBL· GenBank· DDBJ | Genomic DNA |