X0B5W9 · X0B5W9_FUSOX
- ProteinAutophagy-related protein 11
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1278 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Atg1/ULK1 kinase complex | |
Cellular Component | phagophore assembly site membrane | |
Cellular Component | vacuolar membrane | |
Molecular Function | molecular adaptor activity | |
Molecular Function | protein kinase binding | |
Biological Process | autophagosome assembly | |
Biological Process | autophagy of mitochondrion | |
Biological Process | piecemeal microautophagy of the nucleus | |
Biological Process | positive regulation of autophagy of mitochondrion | |
Biological Process | positive regulation of protein phosphorylation | |
Biological Process | protein transport | |
Biological Process | reticulophagy |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameAutophagy-related protein 11
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Hypocreomycetidae > Hypocreales > Nectriaceae > Fusarium > Fusarium oxysporum species complex
Accessions
- Primary accessionX0B5W9
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Preautophagosomal structure membrane ; Peripheral membrane protein
Vacuole membrane ; Peripheral membrane protein
Note: During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.
Keywords
- Cellular component
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 104-448 | Autophagy protein ATG17-like | ||||
Sequence: SSWQELYKERRNWAMHLVEDCGQMNTTTLALYSEIDVIIKCLDAAVANLEISIKTIEPKYNDLKKWVTPALEEHRTLVENWEQYLDLARNTPISPLMVKFMTRQETKKSNPTLEDLIELDTARKAGKLAPTAHRRFSDKANQLNNTASQMYRSLESLIADFEKLMSRSALGHSTDSAQLLEDIEAVVKQMDSDYRAALGYGNTQRDVAQASKTASVHTEHLVPTLKKRVKEMDELLHYATDARNSIASESAKFMRYVTEITSLHNNVKSQINVLNQSVDDMTTFDYLRLIHQLPYMYAAFVSEAVRRREWVDKVKTDSSTLANEMALFQDEESKRRRKWQKMIGS | ||||||
Region | 574-655 | Disordered | ||||
Sequence: HRQSQASRPGNLFQPQGPQQRERGNSGSSIRSSRFDDRRRSSDGIDPLMRRITQLENELREEKQRSSRLQQELTAQSDHHEN | ||||||
Compositional bias | 577-604 | Polar residues | ||||
Sequence: SQASRPGNLFQPQGPQQRERGNSGSSIR | ||||||
Compositional bias | 605-619 | Basic and acidic residues | ||||
Sequence: SSRFDDRRRSSDGID | ||||||
Compositional bias | 626-655 | Basic and acidic residues | ||||
Sequence: TQLENELREEKQRSSRLQQELTAQSDHHEN | ||||||
Coiled coil | 854-986 | |||||
Sequence: IDLLKTKAEHFTATIAELREQLAEKDAKLSEGEMKAVHLRENLAEEKAKVIALEQELADGREQLTELRAKLSDGETGPEALQTRLEEEEKKVMALTEEVASKQSHVGSLEEELRMFQEKAESLQGKMSNLNSQ | ||||||
Region | 1026-1056 | Disordered | ||||
Sequence: MTVTKIPRSERNAQNPNDSSDPGSSLRKSGT | ||||||
Compositional bias | 1032-1056 | Polar residues | ||||
Sequence: PRSERNAQNPNDSSDPGSSLRKSGT | ||||||
Domain | 1102-1240 | Autophagy-related protein 11 C-terminal | ||||
Sequence: ETVYRRIKEVEHMARKWQREARSYREKAHLLQKDSHEKIAFKHFKEGDLALFLPTRNQQAGAWAAFNVGFPHYFLREQDAHRLRHREWLVARISRIQERVVDLSKSLQPSSETDSINDEENDNPFQLSDGLRWYLIDAF | ||||||
Coiled coil | 1108-1135 | |||||
Sequence: IKEVEHMARKWQREARSYREKAHLLQKD |
Sequence similarities
Belongs to the ATG11 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,278
- Mass (Da)146,305
- Last updated2014-05-14 v1
- ChecksumABEA33EB9E853670
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 577-604 | Polar residues | ||||
Sequence: SQASRPGNLFQPQGPQQRERGNSGSSIR | ||||||
Compositional bias | 605-619 | Basic and acidic residues | ||||
Sequence: SSRFDDRRRSSDGID | ||||||
Compositional bias | 626-655 | Basic and acidic residues | ||||
Sequence: TQLENELREEKQRSSRLQQELTAQSDHHEN | ||||||
Compositional bias | 1032-1056 | Polar residues | ||||
Sequence: PRSERNAQNPNDSSDPGSSLRKSGT |