W7LNJ4 · W7LNJ4_GIBM7

Function

function

Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentAtg1/ULK1 kinase complex
Cellular Componentphagophore assembly site membrane
Cellular Componentvacuolar membrane
Molecular Functionmolecular adaptor activity
Molecular Functionprotein kinase binding
Biological Processautophagosome assembly
Biological Processautophagy of mitochondrion
Biological Processpiecemeal microautophagy of the nucleus
Biological Processpositive regulation of autophagy of mitochondrion
Biological Processpositive regulation of protein phosphorylation
Biological Processprotein transport
Biological Processreticulophagy

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Autophagy-related protein 11

Gene names

    • ORF names
      FVEG_00838

Organism names

Accessions

  • Primary accession
    W7LNJ4

Proteomes

Organism-specific databases

Subcellular Location

Preautophagosomal structure membrane
; Peripheral membrane protein
Vacuole membrane
; Peripheral membrane protein
Note: During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain103-448Autophagy protein ATG17-like
Region574-651Disordered
Compositional bias577-604Polar residues
Compositional bias605-619Basic and acidic residues
Compositional bias626-641Basic and acidic residues
Coiled coil836-968
Region1008-1037Disordered
Compositional bias1014-1037Polar residues
Domain1084-1222Autophagy-related protein 11 C-terminal
Compositional bias1187-1207Polar residues
Region1187-1208Disordered

Sequence similarities

Belongs to the ATG11 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,260
  • Mass (Da)
    144,260
  • Last updated
    2014-04-16 v1
  • Checksum
    8AAD8614462B168C
MALQVLIAHTGLRLEVDTAQFSILDDLKAWVSRKTSIPPQHIVALTPQGRTVKSTSLHTEKEMFIYDIRISSPGNANLIIPVPAPKRYVIPNAPNTIDDVQSISSWQELFKERRNWAMHLVEDCGQMNTTTVALYDEIDVIIRCLDAAVANLEISIKTIEPKYNDLKKWVTPALEEHGTLVENWEQYLYLARKTPISPLMVKFMTRQETNKSNPTLEDLIELDTAKKAGKLAPTAHRRFSDKANQLNSTASQMYRSLESLIADFEKLMSRSSLGHSTASAQVLEDIEAVVKQMDSDYRAALGYGNTQRDVAQASKTASVHTEHLVPTLKRRVKEMDELLHYATDARNSIAFDSAKFMRYVTEITSLHNNVKSQINILNQSVDDMTTFDYLRLIHQLPYMYAAFVSEAVRRREWVDKVKTDSSTLANEMALFQDEESKRRRKWQKMIGSMYGPDLDTNVMGLEVNLLGEDKPWPALTKDDLTDFVQLLQEQPVDQSVLDDVLKLVQELDNPTKQQSKRLKAFKNGSIHEVALGRSGLMIRGDDDLLQSLQEDKGKLENKLKTAESRVRRLEDLLHRQSQASRPGNLFQPQGPQQRERGNSGSSIRSSRFDDRRRSSDGVDPLMRRITQLENELREEKQRSSRLQQELTVQSAHHENIKGQHEDLKDLLENMEALEREFVEERKNLENEIKTLRARLEDTEDEIEQFDESRQHEKAGYVVRVEELEAELEQINKQRQDDALKAQGQVEFLRKETRIQKEQQEALEQQVQSAQEEAQDVSRKLSVAEETLGDHWQTLRRLFTELLPEAAAPDNFVDLSDLLLTQAGTLVEKSRNLEADIDILKTKVEHFTTTIAELREQLAEKDTKLSEGDLKAVHMGEKLAEEKAKVIALEQELADGREQLTELRAKLSDGESGPEALQTRLEEEEKRVMALTEEVASKQSHVGSLEEELRMFQEKAESLQGKMSHLNSQYEHRDEKTKDLTQRLYSQNDRMCRLLERVGFAVTRKDGDMTVTKIPRSERNAQNPNESSDPGSSLRKSGTISRVLGDSADLELLYWLNNSDLQAENEKYEAFMNKIGNFDMELFSETVYRRIKEVEHMARKWQREARSYREKTHLLQKDSHDKIAFKHFKEGDLALFLPTRNQQAGAWAAFNVGFPHYFLREQDAHRLRHREWLVARISRIQERVVDLSKSLQPSSETDSINDEENDNPFQLSDGLRWYLIDAFEDKPGAPSTPGMGKSTVAANTVEATANIHTHATGGKES

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
W7LNH0W7LNH0_GIBM7FVEG_008381432
W7LNK0W7LNK0_GIBM7FVEG_008381253
W7LNN3W7LNN3_GIBM7FVEG_008381414
W7LNN8W7LNN8_GIBM7FVEG_008381407
W7LNP2W7LNP2_GIBM7FVEG_008381386
W7LEP0W7LEP0_GIBM7FVEG_008381406
W7LEP4W7LEP4_GIBM7FVEG_008381379
W7LBW9W7LBW9_GIBM7FVEG_008381431
W7LWY8W7LWY8_GIBM7FVEG_008381278
W7LWX4W7LWX4_GIBM7FVEG_008381413
W7LWX9W7LWX9_GIBM7FVEG_008381404

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias577-604Polar residues
Compositional bias605-619Basic and acidic residues
Compositional bias626-641Basic and acidic residues
Compositional bias1014-1037Polar residues
Compositional bias1187-1207Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS022242
EMBL· GenBank· DDBJ
EWG37054.1
EMBL· GenBank· DDBJ
Genomic DNA
DS022242
EMBL· GenBank· DDBJ
EWG37055.1
EMBL· GenBank· DDBJ
Genomic DNA
DS022242
EMBL· GenBank· DDBJ
EWG37056.1
EMBL· GenBank· DDBJ
Genomic DNA
DS022242
EMBL· GenBank· DDBJ
EWG37057.1
EMBL· GenBank· DDBJ
Genomic DNA
DS022242
EMBL· GenBank· DDBJ
EWG37058.1
EMBL· GenBank· DDBJ
Genomic DNA
DS022242
EMBL· GenBank· DDBJ
EWG37059.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp