S7S106 · S7S106_GLOTA

Function

function

Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc2Man9GlcNAc2-PP-Dol to produce Glc3Man9GlcNAc2-PP-Dol.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Pathway

Protein modification; protein glycosylation.

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functiondolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity
Biological Processdolichol-linked oligosaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
  • EC number

Gene names

    • ORF names
      GLOTRDRAFT_69230

Organism names

Accessions

  • Primary accession
    S7S106

Proteomes

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane79-99Helical
Transmembrane111-136Helical
Transmembrane235-257Helical
Transmembrane272-292Helical
Transmembrane313-331Helical
Transmembrane351-375Helical
Transmembrane382-402Helical
Transmembrane422-447Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_500454431924-458Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha-1,2-glucosyltransferase

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ALG10 glucosyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    458
  • Mass (Da)
    51,841
  • Last updated
    2013-10-16 v1
  • Checksum
    086EFEA99D0E9FD6
MASPMHHLVFTGICILVLRELNGIVTEPYMDEPFHVPQAQAYCRGEFSYWDPKITTPPGLYVVSWVLKKIFLFKCNLQMLRLTPMLALVALPIALTHLLSYHQRVRPPSSLLAPTLESVVLSAFPIVWFFGFLYYTEVPSLLFVVLTVVAASQGKHWLAGLLGLVSCTFRQTNVVWVLYAYASSQLMYLRFRRAAPNGSMPAKLHDPPALEAGPGDLLRSILSAPRVLPDVLPKFIPYGIVVALFGAFVVCNGGIVLGDKSNHIPSFHIPQLYYFLGFVTIFGWPVLVSGPGGLKSLIKEVRYRMFGNLRRSLVTAIVSAVMAVTVYKFTIHHPFLLSDNRHYTFYVWRRIFMLHPVVPYLLIPGYIACAWAWFLRVGRDQTLLQTLLLPVFVLPTLLPTPLLEPRYFLIPYVLLRAQVPDVPGWGVLLEGAWYAAINAATMWVFLYREREGVGRFMW

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KB469296
EMBL· GenBank· DDBJ
EPQ61060.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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