Q9Y2Q9 · RT28_HUMAN

  • Protein
    Small ribosomal subunit protein bS1m
  • Gene
    MRPS28
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial small ribosomal subunit
Cellular Componentmitochondrion
Molecular FunctionRNA binding
Biological Processmitochondrial translation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Small ribosomal subunit protein bS1m
  • Alternative names
    • 28S ribosomal protein S28, mitochondrial (MRP-S28; S28mt)
    • 28S ribosomal protein S35, mitochondrial (MRP-S35; S35mt)

Gene names

    • Name
      MRPS28
    • Synonyms
      MRPS35
    • ORF names
      HSPC007

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9Y2Q9
  • Secondary accessions
    • B2RDZ7
    • Q96Q21

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Involvement in disease

Combined oxidative phosphorylation deficiency 47 (COXPD47)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    An autosomal recessive, multisystemic, mitochondrial disorder characterized by intrauterine growth retardation, swallowing difficulties with failure to thrive, hypoglycemia, dehydration, and hepatomegaly. Additional features include global developmental delay with impaired intellectual development and absent speech, microcephaly, facial dysmorphism, cataract, sensorineural deafness, skeletal features, and cryptorchidism. Laboratory studies show metabolic acidosis, increased serum lactate, and variably impaired activity of mitochondrial respiratory complexes I, III, IV, and V in different tissues.
  • See also
    MIM:618958
Natural variants in COXPD47
Variant IDPosition(s)ChangeDescription
VAR_084507119K>Rin COXPD47; strong decrease in mitochondrial translation and in oxidative phosphorylation biogenesis; this phenotype could be reversed in patient's fibroblasts by transfection with the wild-type protein; dbSNP:rs1808705345

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_052047103in dbSNP:rs16919579
Natural variantVAR_084507119in COXPD47; strong decrease in mitochondrial translation and in oxidative phosphorylation biogenesis; this phenotype could be reversed in patient's fibroblasts by transfection with the wild-type protein; dbSNP:rs1808705345

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 263 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for transit peptide, chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Transit peptide1-71UniProtMitochondrion
ChainPRO_000008771472-187UniProtSmall ribosomal subunit protein bS1m
Modified residue73UniProtPhosphoserine
Modified residue (large scale data)73PRIDEPhosphoserine
Modified residue (large scale data)87PRIDEPhosphoserine
Modified residue133UniProtN6-acetyllysine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the mitochondrial small ribosomal subunit (mt-SSU) (PubMed:30566640).
Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins
View interactors in UniProtKB
View CPX-5225 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    187
  • Mass (Da)
    20,843
  • Last updated
    1999-11-01 v1
  • Checksum
    2ED0EA43552B9B54
MAALCRTRAVAAESHFLRVFLFFRPFRGVGTESGSESGSSNAKEPKTRAGGFASALERHSELLQKVEPLQKGSPKNVESFASMLRHSPLTQMGPAKDKLVIGRIFHIVENDLYIDFGGKFHCVCRRPEVDGEKYQKGTRVRLRLLDLELTSRFLGATTDTTVLEANAVLLGIQESKDSRSKEEHHEK

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YAT2H0YAT2_HUMANMRPS28143
H7C5V3H7C5V3_HUMANMRPS28162
U3KQQ8U3KQQ8_HUMANMRPS2883
E5RK86E5RK86_HUMANMRPS28108
E5RFT8E5RFT8_HUMANMRPS2886
E5RGC7E5RGC7_HUMANMRPS28103
E5RFH3E5RFH3_HUMANMRPS28125

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF070663
EMBL· GenBank· DDBJ
AAD20969.1
EMBL· GenBank· DDBJ
mRNA
AK315739
EMBL· GenBank· DDBJ
BAG38094.1
EMBL· GenBank· DDBJ
mRNA
CH471068
EMBL· GenBank· DDBJ
EAW87069.1
EMBL· GenBank· DDBJ
Genomic DNA
BC010150
EMBL· GenBank· DDBJ
AAH10150.1
EMBL· GenBank· DDBJ
mRNA
AB061209
EMBL· GenBank· DDBJ
BAB54959.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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