Q9SRZ0 · CUL2_ARATH

Function

function

Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Involved in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchloroplast envelope
Cellular ComponentSCF ubiquitin ligase complex
Molecular Functionubiquitin protein ligase binding
Biological Processauxin-activated signaling pathway
Biological Processjasmonic acid mediated signaling pathway
Biological Processresponse to auxin
Biological Processresponse to jasmonic acid
Biological Processubiquitin-dependent protein catabolic process

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cullin-2
  • Short names
    AtCUL1

Gene names

    • Name
      CUL2
    • ORF names
      F22D16.2
    • Ordered locus names
      At1g02980

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SRZ0
  • Secondary accessions
    • Q8GY26

Proteomes

Organism-specific databases

Genome annotation databases

PTM/Processing

Features

Showing features for chain, cross-link.

TypeIDPosition(s)Description
ChainPRO_00003968481-742Cullin-2
Cross-link686Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in NEDD8)

Post-translational modification

Neddylated; which enhances the ubiquitination activity of E3 ubiquitin-protein ligase complexes.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with SKIP17 and FBW2/SKIP18.
View interactors in UniProtKB
View CPX-1471 in Complex Portal

Protein-protein interaction databases

    • CPX-1471SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1A
    • CPX-1472SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-SKP1B
    • CPX-1473SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK3
    • CPX-1474SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK4
    • CPX-1475SCF(COI1) ubiquitin ligase complex, variant CUL2-RBX1A-ASK5

Structure

Family & Domains

Sequence similarities

Belongs to the cullin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    742
  • Mass (Da)
    85,965
  • Last updated
    2000-05-01 v1
  • Checksum
    453EF10CDA6A82F8
MAKKDSVLEAGWSVMEAGVAKLQKILEEVPDEPPFDPVQRMQLYTTVHNLCTQKPPNDYSQQIYDRYGGVYVDYNKQTVLPAIREKHGEYMLRELVKRWANQKILVRWLSHFFEYLDRFYTRRGSHPTLSAVGFISFRDLVYQELQSKAKDAVLALIHKEREGEQIDRALLKNVIDVYCGNGMGELVKYEEDFESFLLEDSASYYSRNASRWNQENSCPDYMIKAEESLRLEKERVTNYLHSTTEPKLVAKVQNELLVVVAKQLIENEHSGCRALLRDDKMDDLARMYRLYHPIPQGLDPVADLFKQHITVEGSALIKQATEAATDKAASTSGLKVQDQVLIRQLIDLHDKFMVYVDECFQKHSLFHKALKEAFEVFCNKTVAGVSSAEILATYCDNILKTGGGIEKLENEDLELTLEKVVKLLVYISDKDLFAEFFRKKQARRLLFDRNGNDYHERSLLTKFKELLGAQFTSKMEGMLTDMTLAKEHQTNFVEFLSVNKTKKLGMDFTVTVLTTGFWPSYKTTDLNLPIEMVNCVEAFKAYYGTKTNSRRLSWIYSLGTCQLAGKFDKKTIEIVVTTYQAAVLLLFNNTERLSYTEILEQLNLGHEDLARLLHSLSCLKYKILIKEPMSRNISNTDTFEFNSKFTDKMRRIRVPLPPMDERKKIVEDVDKDRRYAIDAALVRIMKSRKVLGHQQLVSECVEHLSKMFKPDIKMIKKRIEDLISRDYLERDTDNPNTFKYLA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC009525
EMBL· GenBank· DDBJ
AAF02868.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE27509.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
ANM59352.1
EMBL· GenBank· DDBJ
Genomic DNA
AK117909
EMBL· GenBank· DDBJ
BAC42547.1
EMBL· GenBank· DDBJ
mRNA
BT006231
EMBL· GenBank· DDBJ
AAP12880.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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