Q9PTU6 · ENDOU_PAROL

Function

function

Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

138550100150200250300350
TypeIDPosition(s)Description
Active site261
Active site276
Active site319

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Molecular Functionpolysaccharide binding
Molecular FunctionRNA binding
Molecular FunctionRNA endonuclease activity
Molecular Functionscavenger receptor activity
Biological Processimmune response

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate-specific endoribonuclease
  • EC number
  • Alternative names
    • Pancreatic protein with two somatomedin-B domains
    • Protein endoU

Gene names

    • Name
      endou
    • Synonyms
      ppsb

Organism names

Accessions

  • Primary accession
    Q9PTU6

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000039422622-385Uridylate-specific endoribonuclease
Disulfide bond25↔29Alternate
Disulfide bond25↔41Alternate
Disulfide bond29↔59Alternate
Disulfide bond39↔41Alternate
Disulfide bond39↔52Alternate
Disulfide bond45↔51
Disulfide bond52↔59Alternate
Disulfide bond66↔70Alternate
Disulfide bond66↔82Alternate
Disulfide bond70↔100Alternate
Disulfide bond80↔82Alternate
Disulfide bond80↔93Alternate
Disulfide bond86↔92
Disulfide bond93↔100Alternate

Keywords

Expression

Tissue specificity

Specifically expressed by the exocrine pancreatic acinar cells.

Interaction

Subunit

Monomer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-61SMB 1
Domain62-105SMB 2
Domain112-385EndoU

Sequence similarities

Belongs to the ENDOU family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    385
  • Mass (Da)
    43,256
  • Last updated
    2000-05-01 v1
  • Checksum
    A1AE0AA4C461C4C9
MKVIALLTLCVTLFCQGYSNSLDSCQGRCGYGTDNNFSCQCNTSCERFKDCCSDYAEQCKAGATSCKGRCDEKYNSQNKCHCNSKCSRYNNCCSDYTDICDSDAGGGGSVITDADIKAVSEVLYALDSNKATASELIIDPQALVHDSQTSSQRDLSSRPLFRYVDGTLLSRPTYAAFLAVLDNYHRMTGQVEDFSPQQLSEQETFIKEAMSNTELGRELFAFLYTKGVYASENEFLHDLKMMWFGLYSRYNNKMDSSGFEHIFAGEIKGGKVSGFHNWIQFYRLEKRGQLNYYSHSFNGPWTTFPDVMGMQFKWDGYFKQVGSAVIGCSPEFDFALYSLCYITRPGKQCRLSLGGKELIIQTYTWDKTTYGNGKKFIASAFPSTP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB035673
EMBL· GenBank· DDBJ
BAA88246.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp