Q9NYG5 · APC11_HUMAN
- ProteinAnaphase-promoting complex subunit 11
- GeneANAPC11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:11739784, PubMed:18485873).
The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873).
The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).
May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:11739784, PubMed:18485873).
The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:11739784, PubMed:18485873).
The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).
May recruit the E2 ubiquitin-conjugating enzymes to the complex (PubMed:11739784, PubMed:18485873).
Pathway
Protein modification; protein ubiquitination.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 23 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 26 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 34 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 37 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 44 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 51 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 53 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 56 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 58 | Zn2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 59 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 73 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 76 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | anaphase-promoting complex | |
Cellular Component | cytosol | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | cullin family protein binding | |
Molecular Function | ubiquitin protein ligase activity | |
Molecular Function | ubiquitin-ubiquitin ligase activity | |
Molecular Function | zinc ion binding | |
Biological Process | anaphase-promoting complex-dependent catabolic process | |
Biological Process | cell division | |
Biological Process | mitotic cell cycle | |
Biological Process | positive regulation of mitotic metaphase/anaphase transition | |
Biological Process | protein branched polyubiquitination | |
Biological Process | protein K11-linked ubiquitination | |
Biological Process | protein K48-linked ubiquitination | |
Biological Process | protein ubiquitination | |
Biological Process | regulation of meiotic cell cycle | |
Biological Process | regulation of mitotic cell cycle | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnaphase-promoting complex subunit 11
- Short namesAPC11
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NYG5
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 23 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 26 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 34 | Slightly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 37 | Slightly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 44 | Slightly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 51 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 53 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: H → S | ||||||
Mutagenesis | 56 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: H → S | ||||||
Mutagenesis | 58 | Slightly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: H → S | ||||||
Mutagenesis | 59 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 73 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S | ||||||
Mutagenesis | 76 | Greatly reduces autoubiquitination activity; in isoform 1. | ||||
Sequence: C → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 71 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000055747 | 1-84 | Anaphase-promoting complex subunit 11 | |||
Sequence: MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE |
Post-translational modification
Auto-ubiquitinated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte.
Gene expression databases
Organism-specific databases
Interaction
Subunit
The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:10922056, PubMed:25043029, PubMed:26083744).
Interacts with the cullin domain of ANAPC2 (PubMed:11739784).
Interacts with UBE2D2 (PubMed:11739784).
Interacts with the cullin domain of ANAPC2 (PubMed:11739784).
Interacts with UBE2D2 (PubMed:11739784).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 34-77 | RING-type | ||||
Sequence: CPDCKVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCR |
Domain
The RING-type zinc finger domain coordinates an additional third zinc ion.
Sequence similarities
Belongs to the RING-box family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9NYG5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length84
- Mass (Da)9,841
- Last updated2000-10-01 v1
- ChecksumEACBD5A54FDC11AE
Q9NYG5-2
- Name2
- Differences from canonical
- 38-84: KVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE → PLHGESISRCLGWCPQPVPVLGGRAHPQVPINTASPTPGQHTGSLMSREESSRSPDPTPPALDQETSSLLRCTSPWCLDHSCDLFGITDQVSADGPRACRQGARRRLPAGVGPVLPLLPHALHPQVAARTAGAAALPHVPPGMEVQGVRPDLALAGGAS
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
J3KSK3 | J3KSK3_HUMAN | ANAPC11 | 111 | ||
A0A087X1B5 | A0A087X1B5_HUMAN | ANAPC11 | 89 | ||
J3QL35 | J3QL35_HUMAN | ANAPC11 | 44 | ||
J3QS46 | J3QS46_HUMAN | ANAPC11 | 72 |
Sequence caution
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_012347 | 38-84 | in isoform 2 | |||
Sequence: KVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE → PLHGESISRCLGWCPQPVPVLGGRAHPQVPINTASPTPGQHTGSLMSREESSRSPDPTPPALDQETSSLLRCTSPWCLDHSCDLFGITDQVSADGPRACRQGARRRLPAGVGPVLPLLPHALHPQVAARTAGAAALPHVPPGMEVQGVRPDLALAGGAS |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF247565 EMBL· GenBank· DDBJ | AAF65816.1 EMBL· GenBank· DDBJ | mRNA | ||
AF247789 EMBL· GenBank· DDBJ | AAL95694.1 EMBL· GenBank· DDBJ | mRNA | ||
AF151048 EMBL· GenBank· DDBJ | AAF36134.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AC145207 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC000607 EMBL· GenBank· DDBJ | AAH00607.2 EMBL· GenBank· DDBJ | mRNA | ||
BC066308 EMBL· GenBank· DDBJ | AAH66308.1 EMBL· GenBank· DDBJ | mRNA | ||
BC095454 EMBL· GenBank· DDBJ | AAH95454.1 EMBL· GenBank· DDBJ | mRNA | ||
BC104641 EMBL· GenBank· DDBJ | AAI04642.1 EMBL· GenBank· DDBJ | mRNA | ||
BC171892 EMBL· GenBank· DDBJ | AAI71892.1 EMBL· GenBank· DDBJ | mRNA | ||
BC171898 EMBL· GenBank· DDBJ | AAI71898.1 EMBL· GenBank· DDBJ | mRNA | ||
BC171899 EMBL· GenBank· DDBJ | AAI71899.1 EMBL· GenBank· DDBJ | mRNA | ||
BC171900 EMBL· GenBank· DDBJ | AAI71900.1 EMBL· GenBank· DDBJ | mRNA |