Q9LA01 · CCME_RHOCB

Function

function

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.

Features

Showing features for binding site.

115020406080100120140
TypeIDPosition(s)Description
Binding site123heme (UniProtKB | ChEBI); covalent
Binding site127Fe (UniProtKB | ChEBI) of heme (UniProtKB | ChEBI); axial binding residue

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processcytochrome complex assembly
Biological Processprotein-heme linkage

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c-type biogenesis protein CcmE
  • Alternative names
    • Cytochrome c maturation protein E
    • Heme chaperone CcmE

Gene names

    • Name
      ccmE
    • Synonyms
      cycJ
    • Ordered locus names
      RCAP_rcc00554

Organism names

Accessions

  • Primary accession
    Q9LA01
  • Secondary accessions
    • D5ANG5

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-9Cytoplasmic
Transmembrane10-30Helical; Signal-anchor for type II membrane protein
Topological domain31-150Periplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis123Loss of function.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002388511-150Cytochrome c-type biogenesis protein CcmE

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the CcmE/CycJ family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    150
  • Mass (Da)
    15,978
  • Last updated
    2000-10-01 v1
  • Checksum
    57E4E3724E79B934
MRNLKKTRRIQILLVAGGALVLSTALIGYGMRDGINFFRAPSQIVAEPPAAGEVFRLGGLVEAGTLVRGQGEEITFKVTDGGASVPVTFTGVLPDLFGEGKGMVGTGEMVEGTFVAREILAKHDENYMPKEVTEALKEQGVYRDPAQPEG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF156104
EMBL· GenBank· DDBJ
AAF26221.1
EMBL· GenBank· DDBJ
Genomic DNA
CP001312
EMBL· GenBank· DDBJ
ADE84319.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp