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UniProtKB - Q9H6R6 (ZDHC6_HUMAN)

Entry version 153 (07 Apr 2021)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Palmitoyltransferase ZDHHC6

Gene

ZDHHC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC (PubMed:22314232, PubMed:22728137, PubMed:25368151, PubMed:28826475). Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins (PubMed:22314232). Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum (PubMed:22728137). Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation (PubMed:26214738).5 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei129S-palmitoyl cysteine intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H6R6

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Palmitoyltransferase ZDHHC6Curated (EC:2.3.1.2251 Publication)
Alternative name(s):
Stearoyltransferase ZDHHC6Curated (EC:2.3.1.-1 Publication)
Transmembrane protein H41 Publication
Zinc finger DHHC domain-containing protein 61 Publication
Short name:
DHHC-61 Publication
Zinc finger protein 376
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZDHHC6Imported
Synonyms:ZNF376Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:19160, ZDHHC6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618715, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H6R6

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000023041.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 24CytoplasmicCuratedAdd BLAST24
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei25 – 45HelicalSequence analysisAdd BLAST21
Topological domaini46 – 57LumenalCuratedAdd BLAST12
Transmembranei58 – 78HelicalSequence analysisAdd BLAST21
Topological domaini79 – 143CytoplasmicCuratedAdd BLAST65
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 205LumenalCuratedAdd BLAST41
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Topological domaini227 – 413CytoplasmicCuratedAdd BLAST187

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi328 – 329CC → AA: Abolishes palmitoylation, leading to impaired homooligomeization and decreased catalytic activity; when associated with A-343. 1 Publication2
Mutagenesisi343C → A: Abolishes palmitoylation, leading to impaired homooligomeization and decreased catalytic activity; when associated with 328-A-A-329. 1 Publication1
Mutagenesisi409E → A: Does not affect localization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi410K → A: Impaired localization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi411K → A: Impaired localization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi412N → A: Does not affect localization to the endoplasmic reticulum. 1 Publication1
Mutagenesisi413R → A: Does not affect localization to the endoplasmic reticulum. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		64429

Open Targets

More...OpenTargetsi		ENSG00000023041

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38803

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H6R6, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZDHHC6

Domain mapping of disease mutations (DMDM)

More...DMDMi		28202106

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002128711 – 413Palmitoyltransferase ZDHHC6Add BLAST413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi328S-palmitoyl cysteine1 Publication1
Lipidationi329S-palmitoyl cysteine1 Publication1
Lipidationi343S-palmitoyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylated at 3 different sites by ZDHHC16 (PubMed:28826475). The combination of the different palmitoylation events strongly affects the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). Palmitoylation at Cys-328 accelerates the turnover of ZDHHC6 (PubMed:28826475). Depalmitoylated by LYPLA2 (PubMed:28826475).1 Publication

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H6R6

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H6R6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H6R6

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H6R6

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H6R6

PeptideAtlas

More...PeptideAtlasi		Q9H6R6

PRoteomics IDEntifications database

More...PRIDEi		Q9H6R6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		81020 [Q9H6R6-1]
81021 [Q9H6R6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H6R6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H6R6

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H6R6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000023041, Expressed in metanephric glomerulus and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H6R6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H6R6, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000023041, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomerizes (PubMed:28826475).

Interacts with SELENOK (PubMed:25368151).

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		122177, 27 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H6R6

Protein interaction database and analysis system

More...IntActi		Q9H6R6, 18 interactors

Molecular INTeraction database

More...MINTi		Q9H6R6

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358413

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H6R6, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini99 – 149DHHCPROSITE-ProRule annotationAdd BLAST51
Domaini313 – 398SH3PROSITE-ProRule annotationAdd BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi410 – 413Di-lysine motif1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity
The C-terminal di-lysine motif confers endoplasmic reticulum localization.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

SH3 domain, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1314, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155642

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H6R6

Identification of Orthologs from Complete Genome Data

More...OMAi		LCSVIKF

Database of Orthologous Groups

More...OrthoDBi		1491968at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H6R6

TreeFam database of animal gene trees

More...TreeFami		TF320809

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001594, Palmitoyltrfase_DHHC
IPR001452, SH3_domain

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01529, DHHC, 1 hit
PF07653, SH3_2, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50216, DHHC, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H6R6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTFCSVIKF ENLQELKRLC HWGPIIALGV IAICSTMAMI DSVLWYWPLH 
        60         70         80         90        100
TTGGSVNFIM LINWTVMILY NYFNAMFVGP GFVPLGWKPE ISQDTMYLQY 
       110        120        130        140        150
CKVCQAYKAP RSHHCRKCNR CVMKMDHHCP WINNCCGYQN HASFTLFLLL 
       160        170        180        190        200
APLGCIHAAF IFVMTMYTQL YHRLSFGWNT VKIDMSAARR DPLPIVPFGL 
       210        220        230        240        250
AAFATTLFAL GLALGTTIAV GMLFFIQMKI ILRNKTSIES WIEEKAKDRI 
       260        270        280        290        300
QYYQLDEVFV FPYDMGSRWR NFKQVFTWSG VPEGDGLEWP VREGCHQYSL 
       310        320        330        340        350
TIEQLKQKAD KRVRSVRYKV IEDYSGACCP LNKGIKTFFT SPCTEEPRIQ 
       360        370        380        390        400
LQKGEFILAT RGLRYWLYGD KILDDSFIEG VSRIRGWFPR KCVEKCPCDA 
       410 
ETDQAPEGEK KNR
Length:413
Mass (Da):47,663
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4C6CD875FA03713
GO
Isoform 2 (identifier: Q9H6R6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-93: Missing.

Show »
Length:409
Mass (Da):47,205
Checksum:iAC56FA6C4DBDE189
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0D9SEX5A0A0D9SEX5_HUMAN
Palmitoyltransferase
ZDHHC6
383Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15462 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti57N → S in BAD96806 (Ref. 3) Curated1
Sequence conflicti66V → I in BAD96806 (Ref. 3) Curated1
Sequence conflicti78V → A in BAD96806 (Ref. 3) Curated1
Sequence conflicti342P → L in BAB15462 (PubMed:14702039).Curated1
Sequence conflicti370D → G in BAB15462 (PubMed:14702039).Curated1
Sequence conflicti376S → P in BAD96806 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05297441D → N. Corresponds to variant dbSNP:rs34350728Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00693890 – 93Missing in isoform 2. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF267740 mRNA Translation: AAL56663.1
AK025605 mRNA Translation: BAB15187.1
AK026369 mRNA Translation: BAB15462.1 Different initiation.
AK223086 mRNA Translation: BAD96806.1
CH471066 Genomic DNA Translation: EAW49526.1
CH471066 Genomic DNA Translation: EAW49528.1
BC007213 mRNA Translation: AAH07213.1
BC017434 mRNA Translation: AAH17434.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7574.1 [Q9H6R6-1]
CCDS76335.1 [Q9H6R6-2]

NCBI Reference Sequences

More...RefSeqi		NP_001290063.1, NM_001303134.1 [Q9H6R6-2]
NP_071939.1, NM_022494.2 [Q9H6R6-1]
XP_005270108.1, XM_005270051.4
XP_006718011.1, XM_006717948.3
XP_016872050.1, XM_017016561.1
XP_016872051.1, XM_017016562.1 [Q9H6R6-2]
XP_016872052.1, XM_017016563.1 [Q9H6R6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369404; ENSP00000358412; ENSG00000023041 [Q9H6R6-2]
ENST00000369405; ENSP00000358413; ENSG00000023041 [Q9H6R6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		64429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:64429

UCSC genome browser

More...UCSCi		uc001kzv.3, human [Q9H6R6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267740 mRNA Translation: AAL56663.1
AK025605 mRNA Translation: BAB15187.1
AK026369 mRNA Translation: BAB15462.1 Different initiation.
AK223086 mRNA Translation: BAD96806.1
CH471066 Genomic DNA Translation: EAW49526.1
CH471066 Genomic DNA Translation: EAW49528.1
BC007213 mRNA Translation: AAH07213.1
BC017434 mRNA Translation: AAH17434.1
CCDSiCCDS7574.1 [Q9H6R6-1]
CCDS76335.1 [Q9H6R6-2]
RefSeqiNP_001290063.1, NM_001303134.1 [Q9H6R6-2]
NP_071939.1, NM_022494.2 [Q9H6R6-1]
XP_005270108.1, XM_005270051.4
XP_006718011.1, XM_006717948.3
XP_016872050.1, XM_017016561.1
XP_016872051.1, XM_017016562.1 [Q9H6R6-2]
XP_016872052.1, XM_017016563.1 [Q9H6R6-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi122177, 27 interactors
CORUMiQ9H6R6
IntActiQ9H6R6, 18 interactors
MINTiQ9H6R6
STRINGi9606.ENSP00000358413

PTM databases

iPTMnetiQ9H6R6
PhosphoSitePlusiQ9H6R6
SwissPalmiQ9H6R6

Genetic variation databases

BioMutaiZDHHC6
DMDMi28202106

Proteomic databases

EPDiQ9H6R6
jPOSTiQ9H6R6
MassIVEiQ9H6R6
MaxQBiQ9H6R6
PaxDbiQ9H6R6
PeptideAtlasiQ9H6R6
PRIDEiQ9H6R6
ProteomicsDBi81020 [Q9H6R6-1]
81021 [Q9H6R6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18429, 93 antibodies

The DNASU plasmid repository

More...DNASUi		64429

Genome annotation databases

EnsembliENST00000369404; ENSP00000358412; ENSG00000023041 [Q9H6R6-2]
ENST00000369405; ENSP00000358413; ENSG00000023041 [Q9H6R6-1]
GeneIDi64429
KEGGihsa:64429
UCSCiuc001kzv.3, human [Q9H6R6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64429
DisGeNETi64429

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZDHHC6
HGNCiHGNC:19160, ZDHHC6
HPAiENSG00000023041, Low tissue specificity
MIMi618715, gene
neXtProtiNX_Q9H6R6
OpenTargetsiENSG00000023041
PharmGKBiPA38803
VEuPathDBiHostDB:ENSG00000023041.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1314, Eukaryota
GeneTreeiENSGT00940000155642
InParanoidiQ9H6R6
OMAiLCSVIKF
OrthoDBi1491968at2759
PhylomeDBiQ9H6R6
TreeFamiTF320809

Enzyme and pathway databases

PathwayCommonsiQ9H6R6

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		64429, 2 hits in 994 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZDHHC6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		64429
PharosiQ9H6R6, Tdark

Protein Ontology

More...PROi		PR:Q9H6R6
RNActiQ9H6R6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000023041, Expressed in metanephric glomerulus and 231 other tissues
ExpressionAtlasiQ9H6R6, baseline and differential
GenevisibleiQ9H6R6, HS

Family and domain databases

InterProiView protein in InterPro
IPR001594, Palmitoyltrfase_DHHC
IPR001452, SH3_domain
PfamiView protein in Pfam
PF01529, DHHC, 1 hit
PF07653, SH3_2, 1 hit
PROSITEiView protein in PROSITE
PS50216, DHHC, 1 hit
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZDHC6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H6R6
Secondary accession number(s): D3DRB6
, Q53G45, Q96IV7, Q9H605
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2001
Last modified: April 7, 2021
This is version 153 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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