Q9D1T0 · LIGO1_MOUSE

  • Protein
    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
  • Gene
    Lingo1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity).
Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpresynapse
Molecular Functionepidermal growth factor receptor binding
Biological Processcentral nervous system neuron development
Biological Processnegative regulation of oligodendrocyte differentiation
Biological Processnegative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processneuron projection development
Biological Processoligodendrocyte differentiation

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
  • Alternative names
    • Leucine-rich repeat neuronal protein 1
    • Leucine-rich repeat neuronal protein 6A

Gene names

    • Name
      Lingo1
    • Synonyms
      Lern1, Lrrn6a

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9D1T0
  • Secondary accessions
    • Q3TQJ4
    • Q6VVF9
    • Q7TT38

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain36-555Extracellular
Transmembrane556-576Helical
Topological domain577-614Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

In mice lacking Lingo1 and MPTP-intoxicated, a model for Parkinson disease, the dopaminergic neurons survival is increased and behavioral abnormalities reduced.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 41 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, disulfide bond, chain, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-35
Disulfide bond36↔42
ChainPRO_000032864336-614Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
Disulfide bond40↔51
Glycosylation138N-linked (GlcNAc...) asparagine
Glycosylation196N-linked (GlcNAc...) asparagine
Glycosylation258N-linked (GlcNAc...) asparagine
Glycosylation268N-linked (GlcNAc...) asparagine
Glycosylation287N-linked (GlcNAc...) asparagine
Glycosylation335N-linked (GlcNAc...) asparagine
Disulfide bond367↔390
Disulfide bond369↔415
Disulfide bond440↔491
Glycosylation486N-linked (GlcNAc...) asparagine
Glycosylation536N-linked (GlcNAc...) asparagine
Modified residue596Phosphoserine

Post-translational modification

N-glycosylated. Contains predominantly high-mannose glycans (By similarity).

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.

Induction

Up-regulated in brain from MPTP-intoxicated mice, a model for Parkinson disease.

Developmental stage

Expressed broadly at high levels in the whole embryo and becomes progressively restricted to the central nervous system by 14.5 dpc. Extensively expressed across the central nervous system through late embryogenesis and during postnatal development, with a peak of expression around the first week after birth.

Gene expression databases

Interaction

Subunit

Homotetramer. Forms a ternary complex with RTN4R/NGFR and RTN4R/TNFRSF19 (By similarity).
Interacts with NGRF and MYT1L (PubMed:18186492).
Interacts with RTN4R (PubMed:18186492, PubMed:22923615).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9D1T0App P120232EBI-2012981, EBI-78814

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, repeat.

TypeIDPosition(s)Description
Domain36-65LRRNT
Repeat66-87LRR 1
Repeat90-111LRR 2
Repeat114-135LRR 3
Repeat138-159LRR 4
Repeat162-183LRR 5
Repeat186-207LRR 6
Repeat210-231LRR 7
Repeat258-279LRR 8
Repeat282-303LRR 9
Repeat306-327LRR 10
Repeat330-351LRR 11
Domain363-417LRRCT
Domain405-507Ig-like C2-type

Domain

The intracellular domain of LINGO1 interacts with MYT1L.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    614
  • Mass (Da)
    69,101
  • Last updated
    2001-06-01 v1
  • Checksum
    41CFF40C21335681
MLAGGMRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPIGTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESAFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRAHIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A9DA50A9DA50_MOUSELingo1620

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict491in Ref. 3; AAQ97219

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK027262
EMBL· GenBank· DDBJ
BAB32403.1
EMBL· GenBank· DDBJ
mRNA
AK163538
EMBL· GenBank· DDBJ
BAE37388.1
EMBL· GenBank· DDBJ
mRNA
BC052384
EMBL· GenBank· DDBJ
AAH52384.2
EMBL· GenBank· DDBJ
mRNA
BC065696
EMBL· GenBank· DDBJ
AAH65696.1
EMBL· GenBank· DDBJ
mRNA
AY324324
EMBL· GenBank· DDBJ
AAQ97219.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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