Q9BXR5 · TLR10_HUMAN

  • Protein
    Toll-like receptor 10
  • Gene
    TLR10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Caution

In some plant proteins and in human SARM1, the TIR domain has NAD+ hydrolase (NADase) activity (By similarity).
However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity).
Based on this, it is unlikely that Toll-like receptors have NADase activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functionidentical protein binding
Molecular Functionlipopeptide binding
Molecular FunctionNAD+ nucleotidase, cyclic ADP-ribose generating
Molecular Functionsignaling receptor activity
Molecular FunctionToll-like receptor 2 binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processcellular response to bacterial lipopeptide
Biological Processimmune response
Biological Processinflammatory response
Biological Processinnate immune response
Biological Processtoll-like receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Toll-like receptor 10
  • CD Antigen Name
    • CD290

Gene names

    • Name
      TLR10
    • ORF names
      UNQ315/PRO358

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BXR5
  • Secondary accessions
    • A8K7L1
    • B3Y668
    • D1CS21
    • D1CS22
    • Q32MI7

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-576Extracellular
Transmembrane577-597Helical
Topological domain598-811Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_024669163in dbSNP:rs11466649
Natural variantVAR_028125167in dbSNP:rs11466650
Natural variantVAR_024670241in dbSNP:rs11096957
Natural variantVAR_028126298in dbSNP:rs11466651
Natural variantVAR_024671326in dbSNP:rs11466653
Natural variantVAR_024672369in dbSNP:rs11096955
Natural variantVAR_024673381in dbSNP:rs11466655
Natural variantVAR_028127469in dbSNP:rs11466656
Natural variantVAR_028128473in dbSNP:rs11466657
Natural variantVAR_024674525in dbSNP:rs11466658
Natural variantVAR_028129736in dbSNP:rs11466660
Natural variantVAR_059832775in dbSNP:rs4129009
Natural variantVAR_028130775in dbSNP:rs4129009
Natural variantVAR_059833775in dbSNP:rs4129009
Natural variantVAR_059834799in dbSNP:rs4129008
Natural variantVAR_059835799in dbSNP:rs4129008
Natural variantVAR_028131799in dbSNP:rs4129008

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,056 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000003473920-811Toll-like receptor 10
Glycosylation33N-linked (GlcNAc...) asparagine
Glycosylation36N-linked (GlcNAc...) asparagine
Glycosylation140N-linked (GlcNAc...) asparagine
Glycosylation189N-linked (GlcNAc...) asparagine
Glycosylation236N-linked (GlcNAc...) asparagine
Glycosylation278N-linked (GlcNAc...) asparagine
Glycosylation330N-linked (GlcNAc...) asparagine
Glycosylation416N-linked (GlcNAc...) asparagine
Glycosylation427N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Binds MYD88 via their respective TIR domains (By similarity).
Homodimer (Potential)

Binary interactions

View interactors in UniProtKB
View CPX-2524 in Complex Portal

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for repeat, domain.

TypeIDPosition(s)Description
Repeat24-46LRR 1
Repeat49-70LRR 2
Repeat73-94LRR 3
Repeat97-118LRR 4
Repeat119-139LRR 5
Repeat143-166LRR 6
Repeat296-321LRR 7
Repeat325-348LRR 8
Repeat349-368LRR 9
Repeat373-394LRR 10
Repeat398-419LRR 11
Repeat422-442LRR 12
Repeat444-465LRR 13
Repeat467-488LRR 14
Repeat489-509LRR 15
Domain522-576LRRCT
Domain632-775TIR

Sequence similarities

Belongs to the Toll-like receptor family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    811
  • Mass (Da)
    94,564
  • Last updated
    2006-10-17 v2
  • Checksum
    6BFAAEF76886BFBA
MRLIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNVLATREMYELQTFTELNEESRGSTISLMRTDCL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D6RHW6D6RHW6_HUMANTLR1094

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict96in Ref. 5; BAF84715
Sequence conflict562in Ref. 1; AAK26744

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF296673
EMBL· GenBank· DDBJ
AAK26744.1
EMBL· GenBank· DDBJ
mRNA
AB445680
EMBL· GenBank· DDBJ
BAG55077.1
EMBL· GenBank· DDBJ
mRNA
DQ011504
EMBL· GenBank· DDBJ
AAY78479.1
EMBL· GenBank· DDBJ
mRNA
DQ011505
EMBL· GenBank· DDBJ
AAY78480.1
EMBL· GenBank· DDBJ
mRNA
AY358300
EMBL· GenBank· DDBJ
AAQ88667.1
EMBL· GenBank· DDBJ
mRNA
AK292026
EMBL· GenBank· DDBJ
BAF84715.1
EMBL· GenBank· DDBJ
mRNA
CH471069
EMBL· GenBank· DDBJ
EAW92897.1
EMBL· GenBank· DDBJ
Genomic DNA
BC089406
EMBL· GenBank· DDBJ
AAH89406.1
EMBL· GenBank· DDBJ
mRNA
BC109111
EMBL· GenBank· DDBJ
AAI09112.1
EMBL· GenBank· DDBJ
mRNA
BC109112
EMBL· GenBank· DDBJ
AAI09113.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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