Q9BXR5 · TLR10_HUMAN
- ProteinToll-like receptor 10
- GeneTLR10
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids811 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | identical protein binding | |
Molecular Function | lipopeptide binding | |
Molecular Function | NAD+ nucleotidase, cyclic ADP-ribose generating | |
Molecular Function | signaling receptor activity | |
Molecular Function | Toll-like receptor 2 binding | |
Molecular Function | transmembrane signaling receptor activity | |
Biological Process | cellular response to bacterial lipopeptide | |
Biological Process | immune response | |
Biological Process | inflammatory response | |
Biological Process | innate immune response | |
Biological Process | toll-like receptor signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameToll-like receptor 10
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BXR5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 20-576 | Extracellular | ||||
Sequence: DAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNT | ||||||
Transmembrane | 577-597 | Helical | ||||
Sequence: ALLIVTIVVIMLVLGLAVAFC | ||||||
Topological domain | 598-811 | Cytoplasmic | ||||
Sequence: CLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNVLATREMYELQTFTELNEESRGSTISLMRTDCL |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_024669 | 163 | in dbSNP:rs11466649 | |||
Sequence: A → S | ||||||
Natural variant | VAR_028125 | 167 | in dbSNP:rs11466650 | |||
Sequence: L → P | ||||||
Natural variant | VAR_024670 | 241 | in dbSNP:rs11096957 | |||
Sequence: N → H | ||||||
Natural variant | VAR_028126 | 298 | in dbSNP:rs11466651 | |||
Sequence: V → I | ||||||
Natural variant | VAR_024671 | 326 | in dbSNP:rs11466653 | |||
Sequence: M → T | ||||||
Natural variant | VAR_024672 | 369 | in dbSNP:rs11096955 | |||
Sequence: I → L | ||||||
Natural variant | VAR_024673 | 381 | in dbSNP:rs11466655 | |||
Sequence: G → D | ||||||
Natural variant | VAR_028127 | 469 | in dbSNP:rs11466656 | |||
Sequence: R → G | ||||||
Natural variant | VAR_028128 | 473 | in dbSNP:rs11466657 | |||
Sequence: I → T | ||||||
Natural variant | VAR_024674 | 525 | in dbSNP:rs11466658 | |||
Sequence: R → W | ||||||
Natural variant | VAR_028129 | 736 | in dbSNP:rs11466660 | |||
Sequence: Y → C | ||||||
Natural variant | VAR_059832 | 775 | in dbSNP:rs4129009 | |||
Sequence: I → F | ||||||
Natural variant | VAR_028130 | 775 | in dbSNP:rs4129009 | |||
Sequence: I → L | ||||||
Natural variant | VAR_059833 | 775 | in dbSNP:rs4129009 | |||
Sequence: I → V | ||||||
Natural variant | VAR_059834 | 799 | in dbSNP:rs4129008 | |||
Sequence: R → L | ||||||
Natural variant | VAR_059835 | 799 | in dbSNP:rs4129008 | |||
Sequence: R → P | ||||||
Natural variant | VAR_028131 | 799 | in dbSNP:rs4129008 | |||
Sequence: R → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1,056 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MRLIRNIYIFCSIVMTAEG | ||||||
Chain | PRO_0000034739 | 20-811 | Toll-like receptor 10 | |||
Sequence: DAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNIDGKSQFVSYEMQRNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTPLEHLDLSQNLLQHKNDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELNIAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLGLAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAINVNVLATREMYELQTFTELNEESRGSTISLMRTDCL | ||||||
Glycosylation | 33 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 36 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 140 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 189 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 236 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 278 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 330 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 416 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 427 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in spleen, lymph node, thymus, tonsil and at lower levels in lung. Highly expressed in promyelocytic HL-60 cells and in B-cell lines.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binds MYD88 via their respective TIR domains (By similarity).
Homodimer (Potential)
Homodimer (Potential)
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9BXR5 | ATXN3 P54252 | 3 | EBI-16825459, EBI-946046 | |
BINARY | Q9BXR5 | TLR1 Q15399 | 3 | EBI-16825459, EBI-9009517 | |
BINARY | Q9BXR5 | TLR10 Q9BXR5 | 3 | EBI-16825459, EBI-16825459 | |
BINARY | Q9BXR5 | TLR2 O60603 | 3 | EBI-16825459, EBI-973722 | |
BINARY | Q9BXR5 | WFS1 O76024 | 3 | EBI-16825459, EBI-720609 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 24-46 | LRR 1 | ||||
Sequence: LPEERELMTNCSNMSLRKVPADL | ||||||
Repeat | 49-70 | LRR 2 | ||||
Sequence: ATTTLDLSYNLLFQLQSSDFHS | ||||||
Repeat | 73-94 | LRR 3 | ||||
Sequence: KLRVLILCHNRIQQLDLKTFEF | ||||||
Repeat | 97-118 | LRR 4 | ||||
Sequence: ELRYLDLSNNRLKSVTWYLLAG | ||||||
Repeat | 119-139 | LRR 5 | ||||
Sequence: LRYLDLSFNDFDTMPICEEAG | ||||||
Repeat | 143-166 | LRR 6 | ||||
Sequence: HLEILGLSGAKIQKSDFQKIAHLH | ||||||
Repeat | 296-321 | LRR 7 | ||||
Sequence: NTVMRTIKLEHVHFRVFYIQQDKIYL | ||||||
Repeat | 325-348 | LRR 8 | ||||
Sequence: KMDIENLTISNAQMPHMLFPNYPT | ||||||
Repeat | 349-368 | LRR 9 | ||||
Sequence: KFQYLNFANNILTDELFKRT | ||||||
Repeat | 373-394 | LRR 10 | ||||
Sequence: HLKTLILNGNKLETLSLVSCFA | ||||||
Repeat | 398-419 | LRR 11 | ||||
Sequence: PLEHLDLSQNLLQHKNDENCSW | ||||||
Repeat | 422-442 | LRR 12 | ||||
Sequence: TVVNMNLSYNKLSDSVFRCLP | ||||||
Repeat | 444-465 | LRR 13 | ||||
Sequence: SIQILDLNNNQIQTVPKETIHL | ||||||
Repeat | 467-488 | LRR 14 | ||||
Sequence: ALRELNIAFNFLTDLPGCSHFS | ||||||
Repeat | 489-509 | LRR 15 | ||||
Sequence: RLSVLNIEMNFILSPSLDFVQ | ||||||
Domain | 522-576 | LRRCT | ||||
Sequence: NPFRCTCELKNFIQLETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNT | ||||||
Domain | 632-775 | TIR | ||||
Sequence: VRFHAFISYSEHDSLWVKNELIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI |
Sequence similarities
Belongs to the Toll-like receptor family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length811
- Mass (Da)94,564
- Last updated2006-10-17 v2
- Checksum6BFAAEF76886BFBA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D6RHW6 | D6RHW6_HUMAN | TLR10 | 94 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 96 | in Ref. 5; BAF84715 | ||||
Sequence: K → R | ||||||
Sequence conflict | 562 | in Ref. 1; AAK26744 | ||||
Sequence: T → I |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF296673 EMBL· GenBank· DDBJ | AAK26744.1 EMBL· GenBank· DDBJ | mRNA | ||
AB445680 EMBL· GenBank· DDBJ | BAG55077.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ011504 EMBL· GenBank· DDBJ | AAY78479.1 EMBL· GenBank· DDBJ | mRNA | ||
DQ011505 EMBL· GenBank· DDBJ | AAY78480.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358300 EMBL· GenBank· DDBJ | AAQ88667.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292026 EMBL· GenBank· DDBJ | BAF84715.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471069 EMBL· GenBank· DDBJ | EAW92897.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC089406 EMBL· GenBank· DDBJ | AAH89406.1 EMBL· GenBank· DDBJ | mRNA | ||
BC109111 EMBL· GenBank· DDBJ | AAI09112.1 EMBL· GenBank· DDBJ | mRNA | ||
BC109112 EMBL· GenBank· DDBJ | AAI09113.1 EMBL· GenBank· DDBJ | mRNA |