Q9BVL2 · NUP58_HUMAN

  • Protein
    Nucleoporin p58/p45
  • Gene
    NUP58
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.

Miscellaneous

In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnuclear envelope
Cellular Componentnuclear membrane
Cellular Componentnuclear pore
Molecular Functionidentical protein binding
Molecular Functionnuclear localization sequence binding
Molecular Functionprotein-containing complex binding
Molecular Functionstructural constituent of nuclear pore
Biological ProcessmRNA transport
Biological Processnucleocytoplasmic transport
Biological Processprotein transport
Biological Processregulation of protein import into nucleus

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Nucleoporin p58/p45
  • Alternative names
    • 58 kDa nucleoporin
    • Nucleoporin-like protein 1

Gene names

    • Name
      NUP58
    • Synonyms
      KIAA0410, NUPL1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9BVL2
  • Secondary accessions
    • A6NI12
    • B4DZJ1
    • O43160
    • Q5JRG2
    • Q5JRG5

Proteomes

Organism-specific databases

Subcellular Location

Nucleus membrane
; Peripheral membrane protein
Nucleus membrane
; Peripheral membrane protein
Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05057034in dbSNP:rs11556093
Natural variantVAR_050571166in dbSNP:rs12871608

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 583 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002048921-599UniProtNucleoporin p58/p45
Modified residue331UniProtPhosphothreonine
Modified residue (large scale data)331PRIDEPhosphothreonine

Post-translational modification

O-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9BVL2ABI3 Q9P2A47EBI-2811583, EBI-742038
BINARY Q9BVL2AGR2 O959945EBI-2811583, EBI-712648
BINARY Q9BVL2AKAP9 Q99996-33EBI-2811583, EBI-11022349
BINARY Q9BVL2AMBN Q9NP703EBI-2811583, EBI-11893530
BINARY Q9BVL2ARHGAP29 Q52LW3-23EBI-2811583, EBI-22012297
BINARY Q9BVL2ASB9 Q96DX5-33EBI-2811583, EBI-25843552
BINARY Q9BVL2ASIC4 Q96FT7-43EBI-2811583, EBI-9089489
BINARY Q9BVL2ATP5IF1 Q9UII23EBI-2811583, EBI-718459
BINARY Q9BVL2 B7Z3E83EBI-2811583, EBI-25831617
BINARY Q9BVL2BAHD1 Q8TBE03EBI-2811583, EBI-742750
BINARY Q9BVL2BCAS2 O759343EBI-2811583, EBI-1050106
BINARY Q9BVL2BCL3 P207493EBI-2811583, EBI-958997
BINARY Q9BVL2BRK1 Q8WUW13EBI-2811583, EBI-2837444
BINARY Q9BVL2BRME1 Q0VDD73EBI-2811583, EBI-741210
BINARY Q9BVL2CD209 Q9NNX6-103EBI-2811583, EBI-12300031
BINARY Q9BVL2CHMP7 Q8WUX93EBI-2811583, EBI-749253
BINARY Q9BVL2COG3 Q96JB2-26EBI-2811583, EBI-9091495
BINARY Q9BVL2COG6 Q9Y2V73EBI-2811583, EBI-3866319
BINARY Q9BVL2COG8 Q96MW53EBI-2811583, EBI-720875
BINARY Q9BVL2COL25A1 Q8NE083EBI-2811583, EBI-25836642
BINARY Q9BVL2COPS4 Q9BT783EBI-2811583, EBI-742413
BINARY Q9BVL2COX7A1 P243103EBI-2811583, EBI-25876196
BINARY Q9BVL2DCTN3 O75935-23EBI-2811583, EBI-12091947
BINARY Q9BVL2DELE1 Q141543EBI-2811583, EBI-2805660
BINARY Q9BVL2DPP9 Q86TI2-23EBI-2811583, EBI-21529239
BINARY Q9BVL2DPYS Q141173EBI-2811583, EBI-12275416
BINARY Q9BVL2DSN1 Q9H4103EBI-2811583, EBI-1001144
BINARY Q9BVL2E4F1 H3BUJ73EBI-2811583, EBI-10178160
BINARY Q9BVL2EIF3F O003033EBI-2811583, EBI-711990
BINARY Q9BVL2ELK3 P419703EBI-2811583, EBI-1758534
BINARY Q9BVL2ERGIC1 Q969X53EBI-2811583, EBI-781527
BINARY Q9BVL2ESRP1 Q6NXG1-33EBI-2811583, EBI-21567429
BINARY Q9BVL2FAM168B A1KXE4-23EBI-2811583, EBI-12193763
BINARY Q9BVL2FANCG O152873EBI-2811583, EBI-81610
BINARY Q9BVL2FYCO1 Q9BQS8-23EBI-2811583, EBI-25905795
BINARY Q9BVL2GABPB1 Q06547-23EBI-2811583, EBI-618189
BINARY Q9BVL2GABPB1 Q06547-33EBI-2811583, EBI-9088619
BINARY Q9BVL2GINS3 Q9BRX53EBI-2811583, EBI-2857315
BINARY Q9BVL2GKN1 Q9NS713EBI-2811583, EBI-3933251
BINARY Q9BVL2HAUS1 Q96CS23EBI-2811583, EBI-2514791
BINARY Q9BVL2HAUS7 Q998713EBI-2811583, EBI-395719
BINARY Q9BVL2HTT P428587EBI-2811583, EBI-466029
BINARY Q9BVL2ICA1L Q8NDH6-23EBI-2811583, EBI-12141931
BINARY Q9BVL2IFI35 P80217-23EBI-2811583, EBI-12823003
BINARY Q9BVL2IFT20 Q8IY31-23EBI-2811583, EBI-11742277
BINARY Q9BVL2IFT20 Q8IY31-33EBI-2811583, EBI-9091197
BINARY Q9BVL2ITGB3BP Q133526EBI-2811583, EBI-712105
BINARY Q9BVL2KIAA0355 A1A5123EBI-2811583, EBI-25844799
BINARY Q9BVL2KIAA0408 Q6ZU523EBI-2811583, EBI-739493
BINARY Q9BVL2KLC3 Q6P5973EBI-2811583, EBI-1643885
BINARY Q9BVL2KLF3 P576823EBI-2811583, EBI-8472267
BINARY Q9BVL2KLF5 Q138873EBI-2811583, EBI-2696013
BINARY Q9BVL2KRT27 Q7Z3Y83EBI-2811583, EBI-3044087
BINARY Q9BVL2KRT28 Q7Z3Y73EBI-2811583, EBI-11980489
BINARY Q9BVL2KRT33B Q145256EBI-2811583, EBI-1049638
BINARY Q9BVL2LGALS9C Q6DKI23EBI-2811583, EBI-9088829
BINARY Q9BVL2LRRC61 Q9BV993EBI-2811583, EBI-2350424
BINARY Q9BVL2MAOB P273383EBI-2811583, EBI-3911344
BINARY Q9BVL2MED21 Q135033EBI-2811583, EBI-394678
BINARY Q9BVL2MEIS2 O14770-43EBI-2811583, EBI-8025850
BINARY Q9BVL2METTL27 Q8N6F83EBI-2811583, EBI-8487781
BINARY Q9BVL2MIS18A Q9NYP96EBI-2811583, EBI-1104552
BINARY Q9BVL2MRI1 Q9BV203EBI-2811583, EBI-747381
BINARY Q9BVL2MT2A P027953EBI-2811583, EBI-996616
BINARY Q9BVL2NELFCD Q8IXH73EBI-2811583, EBI-536725
BINARY Q9BVL2NEUROD1 Q135623EBI-2811583, EBI-3908303
BINARY Q9BVL2NUP54 Q7Z3B414EBI-2811583, EBI-741048
BINARY Q9BVL2NUP62 P371989EBI-2811583, EBI-347978
BINARY Q9BVL2OIP5 O434823EBI-2811583, EBI-536879
BINARY Q9BVL2OTUD7B Q6GQQ9-23EBI-2811583, EBI-25830200
BINARY Q9BVL2PADI3 Q9ULW83EBI-2811583, EBI-10488185
BINARY Q9BVL2PAIP2 Q9BPZ33EBI-2811583, EBI-2957445
BINARY Q9BVL2PCDHGC3 Q9BR813EBI-2811583, EBI-22012354
BINARY Q9BVL2PIGP P570543EBI-2811583, EBI-17630288
BINARY Q9BVL2PKNOX1 P553476EBI-2811583, EBI-1373569
BINARY Q9BVL2PKNOX2 Q96KN33EBI-2811583, EBI-2692890
BINARY Q9BVL2PMF1 Q6P1K23EBI-2811583, EBI-713832
BINARY Q9BVL2PNKD Q8N490-33EBI-2811583, EBI-25879276
BINARY Q9BVL2PPP1R21 Q6ZMI0-53EBI-2811583, EBI-25835994
BINARY Q9BVL2PSMC2 P359983EBI-2811583, EBI-359710
BINARY Q9BVL2REX1BD Q96EN93EBI-2811583, EBI-745810
BINARY Q9BVL2RGR P47804-33EBI-2811583, EBI-25834767
BINARY Q9BVL2RNF31 Q96EP03EBI-2811583, EBI-948111
BINARY Q9BVL2SCAPER Q9BY12-33EBI-2811583, EBI-25837959
BINARY Q9BVL2SMARCD1 Q96GM53EBI-2811583, EBI-358489
BINARY Q9BVL2SPATA12 Q7Z6I53EBI-2811583, EBI-10696971
BINARY Q9BVL2STAM Q92783-23EBI-2811583, EBI-12025738
BINARY Q9BVL2STAM2 O758863EBI-2811583, EBI-373258
BINARY Q9BVL2STAT4 Q147653EBI-2811583, EBI-1186538
BINARY Q9BVL2STX19 Q8N4C73EBI-2811583, EBI-8484990
BINARY Q9BVL2SYCE3 A1L1903EBI-2811583, EBI-10283466
BINARY Q9BVL2TADA3 O755283EBI-2811583, EBI-473249
BINARY Q9BVL2TEN1 Q86WV53EBI-2811583, EBI-2562799
BINARY Q9BVL2TEX12 Q9BXU03EBI-2811583, EBI-12090309
BINARY Q9BVL2TMTC1 Q8IUR5-43EBI-2811583, EBI-9089156
BINARY Q9BVL2TRAF1 Q130779EBI-2811583, EBI-359224
BINARY Q9BVL2TRIM69 Q86WT6-23EBI-2811583, EBI-11525489
BINARY Q9BVL2TSACC Q96A043EBI-2811583, EBI-740411
BINARY Q9BVL2TSC1 Q86WV83EBI-2811583, EBI-12806590
BINARY Q9BVL2TSNAX Q995983EBI-2811583, EBI-21353855
BINARY Q9BVL2TSPAN2 O606363EBI-2811583, EBI-3914288
BINARY Q9BVL2TTC33 Q6PID63EBI-2811583, EBI-2555404
BINARY Q9BVL2UBE2A P494593EBI-2811583, EBI-2339348
BINARY Q9BVL2UBQLN1 Q9UMX0-23EBI-2811583, EBI-10173939
BINARY Q9BVL2UBQLN2 Q9UHD93EBI-2811583, EBI-947187
BINARY Q9BVL2UBQLN3 Q9H3473EBI-2811583, EBI-25832660
BINARY Q9BVL2VPS37A Q8NEZ23EBI-2811583, EBI-2850578
BINARY Q9BVL2VSX2 P583043EBI-2811583, EBI-6427899
BINARY Q9BVL2YRDC Q86U903EBI-2811583, EBI-21659356
BINARY Q9BVL2ZBTB8OS Q8IWT0-23EBI-2811583, EBI-12956041
BINARY Q9BVL2ZNF488 Q96MN9-23EBI-2811583, EBI-25831733
BINARY Q9BVL2ZWINT O952293EBI-2811583, EBI-1001132

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for repeat, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Repeat7-81
Region7-57914 X 2 AA repeats of F-G
Repeat30-312
Repeat44-453
Repeat63-644
Repeat68-695
Region213-247Disordered
Compositional bias224-244Basic and acidic residues
Coiled coil256-276
Coiled coil314-381
Repeat488-4896
Repeat492-4937
Repeat513-5148
Repeat519-5209
Repeat529-53010
Repeat531-53211
Repeat545-54612
Repeat568-56913
Repeat578-57914
Region579-599Disordered

Domain

Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.

Sequence similarities

Belongs to the NUP58 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9BVL2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    p58
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    599
  • Mass (Da)
    60,897
  • Last updated
    2001-06-01 v1
  • Checksum
    2CC32E2A1B9E5132
MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR

Q9BVL2-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9BVL2-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 12 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WCJ8F8WCJ8_HUMANNUP5862
F8WBZ1F8WBZ1_HUMANNUP5836
Q5JRG1Q5JRG1_HUMANNUP58463
H7BYF2H7BYF2_HUMANNUP58510
A0A8Q3WLQ2A0A8Q3WLQ2_HUMANNUP58404
A0A8Q3WKK3A0A8Q3WKK3_HUMANNUP58528
A0A8Q3WKK5A0A8Q3WKK5_HUMANNUP58570
A0A8Q3WKL0A0A8Q3WKL0_HUMANNUP58231
A0A8Q3WKL7A0A8Q3WKL7_HUMANNUP58566
A0A8Q3WKL9A0A8Q3WKL9_HUMANNUP58131
A0A8Q3WKM2A0A8Q3WKM2_HUMANNUP5836
A0A8Q3WKQ7A0A8Q3WKQ7_HUMANNUP58584

Sequence caution

The sequence BAA23706.2 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_04565884-95in isoform 3
Compositional bias224-244Basic and acidic residues
Alternative sequenceVSP_007946480-485in isoform 2
Alternative sequenceVSP_007947486-599in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB007870
EMBL· GenBank· DDBJ
BAA23706.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AK302946
EMBL· GenBank· DDBJ
BAG64103.1
EMBL· GenBank· DDBJ
mRNA
AL138958
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL590787
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL646102
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC001104
EMBL· GenBank· DDBJ
AAH01104.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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