Q9BVL2 · NUP58_HUMAN
- ProteinNucleoporin p58/p45
- GeneNUP58
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids599 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane.
Miscellaneous
In rat, the p62 complex contains two different isoforms of NUP58. Isoform p45 has however not been isolated in human so far.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nuclear envelope | |
Cellular Component | nuclear membrane | |
Cellular Component | nuclear pore | |
Molecular Function | identical protein binding | |
Molecular Function | nuclear localization sequence binding | |
Molecular Function | protein-containing complex binding | |
Molecular Function | structural constituent of nuclear pore | |
Biological Process | mRNA transport | |
Biological Process | nucleocytoplasmic transport | |
Biological Process | protein transport | |
Biological Process | regulation of protein import into nucleus |
Keywords
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameNucleoporin p58/p45
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9BVL2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Nucleus membrane ; Peripheral membrane protein
Nucleus membrane ; Peripheral membrane protein
Note: Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter.
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_050570 | 34 | in dbSNP:rs11556093 | |||
Sequence: A → T | ||||||
Natural variant | VAR_050571 | 166 | in dbSNP:rs12871608 | |||
Sequence: S → P |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 583 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000204892 | 1-599 | UniProt | Nucleoporin p58/p45 | |||
Sequence: MSTGFSFGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFGTGGQLLQLKKPPAGNKRGKR | |||||||
Modified residue | 331 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 331 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Post-translational modification
O-glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Component of the p62 complex, a complex at least composed of NUP62, NUP54, and NUP58. Interacts with NUTF2. Interacts with SRP1-alpha and Importin p97 proteins when they are together, but not with SRP1-alpha protein alone (By similarity).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 7-8 | 1 | ||||
Sequence: FG | ||||||
Region | 7-579 | 14 X 2 AA repeats of F-G | ||||
Sequence: FGSGTLGSTTVAAGGTSTGGVFSFGTGASSNPSVGLNFGNLGSTSTPATTSAPSSGFGTGLFGSKPATGFTLGGTNTGIATTITTGLTLGTPATTSAATTGFSLGFNKPAASATPFALPITSTSASGLTLSSALTSTPAASTGFTLNNLGGTTATTTTASTGLSLGGALAGLGGSLFQSTNTGTSGLGQNALGLTLGTTAATSTAGNEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENLPPVICQDVENLQKFVKEQKQVQEEISRMSSKAMLKVQEDIKALKQLLSLAANGIQRNTLNIDKLKIETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHITPQDLSMAMQKIYQTFVALAAQLQSIHENVKVLKEQYLGYRKMFLGDAVDVFETRRAEAKKWQNTPRVTTGPTPFSTMPNAAAVAMAATLTQQQQPATGPQPSLGVSFGTPFGSGIGTGLQSSGLGSSNLGGFGTSSGFGCSTTGASTFGFGTTNKPSGSLSAGFGSSSTSGFNFSNPGITASAGLTFGVSNPASAGFG | ||||||
Repeat | 30-31 | 2 | ||||
Sequence: FG | ||||||
Repeat | 44-45 | 3 | ||||
Sequence: FG | ||||||
Repeat | 63-64 | 4 | ||||
Sequence: FG | ||||||
Repeat | 68-69 | 5 | ||||
Sequence: FG | ||||||
Region | 213-247 | Disordered | ||||
Sequence: NEGLGGIDFSSSSDKKSDKTGTRPEDSKALKDENL | ||||||
Compositional bias | 224-244 | Basic and acidic residues | ||||
Sequence: SSDKKSDKTGTRPEDSKALKD | ||||||
Coiled coil | 256-276 | |||||
Sequence: ENLQKFVKEQKQVQEEISRMS | ||||||
Coiled coil | 314-381 | |||||
Sequence: ETAQELKNAEIALRTQKTPPGLQHEYAAPADYFRILVQQFEVQLQQYRQQIEELENHLATQANNSHIT | ||||||
Repeat | 488-489 | 6 | ||||
Sequence: FG | ||||||
Repeat | 492-493 | 7 | ||||
Sequence: FG | ||||||
Repeat | 513-514 | 8 | ||||
Sequence: FG | ||||||
Repeat | 519-520 | 9 | ||||
Sequence: FG | ||||||
Repeat | 529-530 | 10 | ||||
Sequence: FG | ||||||
Repeat | 531-532 | 11 | ||||
Sequence: FG | ||||||
Repeat | 545-546 | 12 | ||||
Sequence: FG | ||||||
Repeat | 568-569 | 13 | ||||
Sequence: FG | ||||||
Repeat | 578-579 | 14 | ||||
Sequence: FG | ||||||
Region | 579-599 | Disordered | ||||
Sequence: GTGGQLLQLKKPPAGNKRGKR |
Domain
Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited.
Sequence similarities
Belongs to the NUP58 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q9BVL2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Synonymsp58
- Length599
- Mass (Da)60,897
- Last updated2001-06-01 v1
- Checksum2CC32E2A1B9E5132
Q9BVL2-2
- Name2
Q9BVL2-3
- Name3
- Differences from canonical
- 84-95: Missing
Computationally mapped potential isoform sequences
There are 12 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F8WCJ8 | F8WCJ8_HUMAN | NUP58 | 62 | ||
F8WBZ1 | F8WBZ1_HUMAN | NUP58 | 36 | ||
Q5JRG1 | Q5JRG1_HUMAN | NUP58 | 463 | ||
H7BYF2 | H7BYF2_HUMAN | NUP58 | 510 | ||
A0A8Q3WLQ2 | A0A8Q3WLQ2_HUMAN | NUP58 | 404 | ||
A0A8Q3WKK3 | A0A8Q3WKK3_HUMAN | NUP58 | 528 | ||
A0A8Q3WKK5 | A0A8Q3WKK5_HUMAN | NUP58 | 570 | ||
A0A8Q3WKL0 | A0A8Q3WKL0_HUMAN | NUP58 | 231 | ||
A0A8Q3WKL7 | A0A8Q3WKL7_HUMAN | NUP58 | 566 | ||
A0A8Q3WKL9 | A0A8Q3WKL9_HUMAN | NUP58 | 131 | ||
A0A8Q3WKM2 | A0A8Q3WKM2_HUMAN | NUP58 | 36 | ||
A0A8Q3WKQ7 | A0A8Q3WKQ7_HUMAN | NUP58 | 584 |
Sequence caution
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_045658 | 84-95 | in isoform 3 | |||
Sequence: Missing | ||||||
Compositional bias | 224-244 | Basic and acidic residues | ||||
Sequence: SSDKKSDKTGTRPEDSKALKD | ||||||
Alternative sequence | VSP_007946 | 480-485 | in isoform 2 | |||
Sequence: PQPSLG → LNAFKL | ||||||
Alternative sequence | VSP_007947 | 486-599 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB007870 EMBL· GenBank· DDBJ | BAA23706.2 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AK302946 EMBL· GenBank· DDBJ | BAG64103.1 EMBL· GenBank· DDBJ | mRNA | ||
AL138958 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL590787 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL646102 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC001104 EMBL· GenBank· DDBJ | AAH01104.1 EMBL· GenBank· DDBJ | mRNA |