Q8WTR7 · ZN473_HUMAN

  • Protein
    Zinc finger protein 473
  • Gene
    ZNF473
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCajal body
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular Functionmetal ion binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological ProcessmRNA 3'-end processing by stem-loop binding and cleavage
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Community curation (1)

The subsequence AEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETK, which contains the KRAB domain, shows transcriptional activator activity in a high-throughput recruitment assay.

Names & Taxonomy

Protein names

  • Recommended name
    Zinc finger protein 473
  • Alternative names
    • Zinc finger protein 100 homolog (Zfp-100)

Gene names

    • Name
      ZNF473
    • Synonyms
      KIAA1141, ZFP100
Community curation (1)

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8WTR7
  • Secondary accessions
    • A8K8T7
    • Q9ULS9
    • Q9Y4Q7

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05283959in dbSNP:rs10419876
Natural variantVAR_05284074in dbSNP:rs10419911
Natural variantVAR_052841164in dbSNP:rs16981705
Natural variantVAR_052842309in dbSNP:rs16981706
Natural variantVAR_052843654in dbSNP:rs10424809
Natural variantVAR_052844662in dbSNP:rs10426374

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 978 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, cross-link, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000476041-871UniProtZinc finger protein 473
Cross-link148UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)157PRIDEPhosphoserine
Cross-link419UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link549UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link558UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link635UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Family & Domains

Features

Showing features for domain, region, zinc finger, compositional bias.

TypeIDPosition(s)Description
Domain6-75KRAB
Region47-81Disordered
Region140-164Disordered
Zinc finger209-231C2H2-type 1
Zinc finger265-286C2H2-type 2; degenerate
Compositional bias290-317Basic and acidic residues
Region290-318Disordered
Region312-552Interaction with SLBP/pre-mRNA complex
Zinc finger320-342C2H2-type 3
Zinc finger347-369C2H2-type 4
Zinc finger375-397C2H2-type 5
Zinc finger403-425C2H2-type 6; degenerate
Zinc finger431-453C2H2-type 7
Zinc finger459-481C2H2-type 8
Zinc finger487-509C2H2-type 9
Zinc finger515-537C2H2-type 10
Zinc finger562-584C2H2-type 11
Zinc finger591-613C2H2-type 12
Zinc finger646-668C2H2-type 13
Zinc finger674-696C2H2-type 14
Zinc finger702-724C2H2-type 15
Zinc finger730-752C2H2-type 16
Zinc finger758-780C2H2-type 17
Zinc finger786-808C2H2-type 18
Zinc finger814-836C2H2-type 19
Zinc finger842-864C2H2-type 20

Domain

The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    871
  • Mass (Da)
    100,182
  • Last updated
    2002-03-01 v1
  • Checksum
    959AFB7C3C2D5456
MAEEFVTLKDVGMDFTLGDWEQLGLEQGDTFWDTALDNCQDLFLLDPPRPNLTSHPDGSEDLEPLAGGSPEATSPDVTETKNSPLMEDFFEEGFSQEIIEMLSKDGFWNSNFGEACIEDTWLDSLLGDPESLLRSDIATNGESPTECKSHELKRGLSPVSTVSTGEDSMVHNVSEKTLTPAKSKEYRGEFFSYSDHSQQDSVQEGEKPYQCSECGKSFSGSYRLTQHWITHTREKPTVHQECEQGFDRNASLSVYPKTHTGYKFYVCNEYGTTFSQSTYLWHQKTHTGEKPCKSQDSDHPPSHDTQPGEHQKTHTDSKSYNCNECGKAFTRIFHLTRHQKIHTRKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSLLIEHQALHAGEEPYKCNERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQECVRSFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICGSTLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFECDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSHSAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQHERTHARKKPLVCNECGKTFRQSSCLSKHQRIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPYRCGECGKAFAQKANLTQHQRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRCQKAFRCHSSLSRHQRVHNKQQYCL

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8WEC7F8WEC7_HUMANZNF473859
M0R123M0R123_HUMANZNF47377
M0R032M0R032_HUMANZNF47374
M0R2N2M0R2N2_HUMANZNF47364
M0QZY7M0QZY7_HUMANZNF473102

Sequence caution

The sequence BAA86455.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias290-317Basic and acidic residues
Sequence conflict486in Ref. 6
Sequence conflict588in Ref. 2; BAA86455

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF454744
EMBL· GenBank· DDBJ
AAL51029.1
EMBL· GenBank· DDBJ
mRNA
AB032967
EMBL· GenBank· DDBJ
BAA86455.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK292452
EMBL· GenBank· DDBJ
BAF85141.1
EMBL· GenBank· DDBJ
mRNA
CH471177
EMBL· GenBank· DDBJ
EAW52593.1
EMBL· GenBank· DDBJ
Genomic DNA
BC018612
EMBL· GenBank· DDBJ
AAH18612.1
EMBL· GenBank· DDBJ
mRNA
AL080143
EMBL· GenBank· DDBJ
CAB45736.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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