UniProtKB - Q8VZU2 (SY132_ARATH)
Protein
Syntaxin-132
Gene
SYP132
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Vesicle trafficking protein that functions in the secretory pathway (Probable). Acts in coordination with SYP123 to mediate tip-focused membrane trafficking for root hair tip growth (PubMed:24642714). Functions in root hair elongation by forming SNARE complexes with VAMP721,VAMP722 or VAMP724 (PubMed:24642714). Involved in cytokinesis (PubMed:29396117). Acts as a cell plate-specific syntaxin, required for the fusion of vesicles at the plane of cell division (PubMed:29396117). Required for secretory trafficking to the plasma membrane during interphase (PubMed:29396117). Involved in the regulation of density of the H+ ATPase proteins at the plasma membrane of root and shoot in epidermal cells (PubMed:30926657). Modulation of SYP132 expression by auxin affects clathrin-sensitive H+ ATPase traffic from the plasma membrane, and influences apoplastic acidification and plant growth (PubMed:30926657).1 Publication3 Publications
Miscellaneous
Plants silencing SYP132 exhibit reduced root hair length.1 Publication
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cell division Source: UniProtKB-KW
- exocytosis Source: GO_Central
- intracellular protein transport Source: GO_Central
- regulation of growth Source: UniProtKB-KW
- vesicle docking Source: GO_Central
- vesicle fusion Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Growth regulation, Protein transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Syntaxin-132CuratedShort name: AtSYP132Curated |
Gene namesi | Name:SYP1321 Publication Ordered Locus Names:At5g08080Imported ORF Names:T22D6.20Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT5G08080 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type IV membrane protein Sequence analysis
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- endomembrane system Source: GO_Central
- integral component of membrane Source: GO_Central
- SNARE complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 275 | CytoplasmicSequence analysisAdd BLAST | 275 | |
Transmembranei | 276 – 296 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 297 – 304 | VesicularSequence analysis | 8 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Defect in cytokinesis in embryos and defect in seedling growth.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210252 | 1 – 304 | Syntaxin-132Add BLAST | 304 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
ProteomicsDBi | 226775 [Q8VZU2-1] |
PTM databases
iPTMneti | Q8VZU2 |
SwissPalmi | Q8VZU2 |
Expressioni
Tissue specificityi
Widely expressed in all tissues throughout plant development.1 Publication
Inductioni
Induced by auxin in roots (PubMed:30926657). Down-regulated by auxin in shoots (PubMed:30926657).1 Publication
Gene expression databases
ExpressionAtlasi | Q8VZU2, baseline and differential |
Genevisiblei | Q8VZU2, AT |
Interactioni
Subunit structurei
Part of the t-SNARE complex.
By similarityGO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 15980, 54 interactors |
IntActi | Q8VZU2, 53 interactors |
STRINGi | 3702.AT5G08080.3 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 204 – 266 | t-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 63 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 34 – 67 | Sequence analysisAdd BLAST | 34 | |
Coiled coili | 129 – 162 | Sequence analysisAdd BLAST | 34 |
Sequence similaritiesi
Belongs to the syntaxin family.Curated
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0810, Eukaryota |
InParanoidi | Q8VZU2 |
OMAi | GQIRKQQ |
PhylomeDBi | Q8VZU2 |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry describes 1 produced by isoform ialternative splicing. AlignAdd to basketNote: A number of isoforms are produced. According to EST sequences.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q8VZU2-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MNDLLKGSFE LPRGQSSREG DVELGEQQGG DQGLEDFFKK VQVIDKQYDK
60 70 80 90 100
LDKLLKKLQA SHEESKSVTK APAMKAIKKT MEKDVDEVGS IARFIKGKLE
110 120 130 140 150
ELDRENLANR QKPGCAKGSG VDRSRTATTL SLKKKLKDKM AEFQVLRENI
160 170 180 190 200
QQEYRDVVDR RVYTVTGERA DEDTIDELIE TGNSEQIFQK AIQEQGRGQV
210 220 230 240 250
MDTLAEIQER HDAVRDLEKK LLDLQQIFLD MAVLVDAQGE MLDNIESQVS
260 270 280 290 300
SAVDHVQSGN TALQRAKSLQ KNSRKWMCIA IIILLIVVAV IVVGVLKPWK
NKSA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF4K9K2 | F4K9K2_ARATH | Syntaxin of plants 132 | SYP132 ATSYP132, syntaxin of plants 132, At5g08080, T22D6.20, T22D6_20 | 315 | Annotation score: | ||
F4K9K4 | F4K9K4_ARATH | Syntaxin of plants 132 | SYP132 ATSYP132, syntaxin of plants 132, At5g08080, T22D6.20, T22D6_20 | 223 | Annotation score: |
Sequence cautioni
The sequence CAB93709 differs from that shown. Reason: Erroneous gene model prediction.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL357612 Genomic DNA Translation: CAB93709.1 Sequence problems. CP002688 Genomic DNA Translation: AED91242.1 CP002688 Genomic DNA Translation: ANM70609.1 AY063836 mRNA Translation: AAL36192.1 AY117244 mRNA Translation: AAM51319.1 |
PIRi | T50493 |
RefSeqi | NP_001332203.1, NM_001342979.1 [Q8VZU2-1] NP_568187.1, NM_120890.3 [Q8VZU2-1] |
Genome annotation databases
EnsemblPlantsi | AT5G08080.1; AT5G08080.1; AT5G08080 [Q8VZU2-1] AT5G08080.4; AT5G08080.4; AT5G08080 [Q8VZU2-1] |
GeneIDi | 830702 |
Gramenei | AT5G08080.1; AT5G08080.1; AT5G08080 [Q8VZU2-1] AT5G08080.4; AT5G08080.4; AT5G08080 [Q8VZU2-1] |
KEGGi | ath:AT5G08080 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL357612 Genomic DNA Translation: CAB93709.1 Sequence problems. CP002688 Genomic DNA Translation: AED91242.1 CP002688 Genomic DNA Translation: ANM70609.1 AY063836 mRNA Translation: AAL36192.1 AY117244 mRNA Translation: AAM51319.1 |
PIRi | T50493 |
RefSeqi | NP_001332203.1, NM_001342979.1 [Q8VZU2-1] NP_568187.1, NM_120890.3 [Q8VZU2-1] |
3D structure databases
SMRi | Q8VZU2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 15980, 54 interactors |
IntActi | Q8VZU2, 53 interactors |
STRINGi | 3702.AT5G08080.3 |
PTM databases
iPTMneti | Q8VZU2 |
SwissPalmi | Q8VZU2 |
Proteomic databases
ProteomicsDBi | 226775 [Q8VZU2-1] |
Genome annotation databases
EnsemblPlantsi | AT5G08080.1; AT5G08080.1; AT5G08080 [Q8VZU2-1] AT5G08080.4; AT5G08080.4; AT5G08080 [Q8VZU2-1] |
GeneIDi | 830702 |
Gramenei | AT5G08080.1; AT5G08080.1; AT5G08080 [Q8VZU2-1] AT5G08080.4; AT5G08080.4; AT5G08080 [Q8VZU2-1] |
KEGGi | ath:AT5G08080 |
Organism-specific databases
Araporti | AT5G08080 |
Phylogenomic databases
eggNOGi | KOG0810, Eukaryota |
InParanoidi | Q8VZU2 |
OMAi | GQIRKQQ |
PhylomeDBi | Q8VZU2 |
Miscellaneous databases
PROi | PR:Q8VZU2 |
Gene expression databases
ExpressionAtlasi | Q8VZU2, baseline and differential |
Genevisiblei | Q8VZU2, AT |
Family and domain databases
CDDi | cd00179, SynN, 1 hit |
InterProi | View protein in InterPro IPR010989, SNARE IPR006012, Syntaxin/epimorphin_CS IPR006011, Syntaxin_N IPR000727, T_SNARE_dom |
Pfami | View protein in Pfam PF05739, SNARE, 1 hit PF00804, Syntaxin, 1 hit |
SMARTi | View protein in SMART SM00503, SynN, 1 hit SM00397, t_SNARE, 1 hit |
SUPFAMi | SSF47661, SSF47661, 1 hit |
PROSITEi | View protein in PROSITE PS00914, SYNTAXIN, 1 hit PS50192, T_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SY132_ARATH | |
Accessioni | Q8VZU2Primary (citable) accession number: Q8VZU2 Secondary accession number(s): Q9LEZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 12, 2003 |
Last sequence update: | March 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families