Q8N149 · LIRA2_HUMAN

  • Protein
    Leukocyte immunoglobulin-like receptor subfamily A member 2
  • Gene
    LILRA2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839).
Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839).
Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839).
Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839).
Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839).
In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404).
In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506).
Does not bind class I MHC antigens (PubMed:19230061).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentplasma membrane
Molecular Functionantigen binding
Molecular FunctionIgM binding
Molecular Functioninhibitory MHC class I receptor activity
Molecular Functionsignaling receptor activity
Biological Processdefense response
Biological Processimmune response-regulating signaling pathway
Biological Processinnate immune response
Biological Processinnate immune response activating cell surface receptor signaling pathway
Biological Processinterleukin-10-mediated signaling pathway
Biological Processnegative regulation of lipopolysaccharide-mediated signaling pathway
Biological Processnegative regulation of toll-like receptor 4 signaling pathway
Biological Processneutrophil activation involved in immune response
Biological Processpositive regulation of calcium ion transport
Biological Processpositive regulation of cell activation
Biological Processpositive regulation of granulocyte colony-stimulating factor production
Biological Processpositive regulation of granulocyte macrophage colony-stimulating factor production
Biological Processpositive regulation of interleukin-1 beta production
Biological Processpositive regulation of interleukin-6 production
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of tumor necrosis factor production
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Leukocyte immunoglobulin-like receptor subfamily A member 2
  • Alternative names
    • CD85 antigen-like family member H
    • Immunoglobulin-like transcript 1 (ILT-1)
    • Leukocyte immunoglobulin-like receptor 7
      (LIR-7
      )
  • CD Antigen Name
    • CD85h

Gene names

    • Name
      LILRA2
    • Synonyms
      ILT1, LIR7

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8N149
  • Secondary accessions
    • O75020

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Isoform 4

Secreted

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain24-449Extracellular
Transmembrane450-470Helical
Topological domain471-483Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_01698825in dbSNP:rs1834697
Natural variantVAR_01698925in dbSNP:rs1834698
Natural variantVAR_056051331in dbSNP:rs7249811
Natural variantVAR_056052361in dbSNP:rs7249154
Natural variantVAR_056053381in dbSNP:rs7249054

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 991 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, modified residue.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_000001481724-483Leukocyte immunoglobulin-like receptor subfamily A member 2
Disulfide bond49↔97
Glycosylation64N-linked (GlcNAc...) asparagine
Glycosylation103N-linked (GlcNAc...) asparagine
Glycosylation138N-linked (GlcNAc...) asparagine
Disulfide bond143↔195
Disulfide bond244↔295
Glycosylation279N-linked (GlcNAc...) asparagine
Glycosylation300N-linked (GlcNAc...) asparagine
Glycosylation339N-linked (GlcNAc...) asparagine
Disulfide bond344↔395
Modified residue4043'-nitrotyrosine
Glycosylation429N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected on the surface of all peripheral blood monocytes, neutrophils, basophils and eosinophils (at protein level) (PubMed:12529506, PubMed:22479404).
Expression levels are very low or not detectable on monocytes, T-cells, B-cells, dendritic cells and natural killer (NK) cells (PubMed:9548455).

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Miscellaneous

Structure

3D structure databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-113Ig-like C2-type 1
Domain117-222Ig-like C2-type 2
Domain224-313Ig-like C2-type 3
Domain324-413Ig-like C2-type 4

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 4 isoforms produced by Alternative splicing.

Q8N149-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    483
  • Mass (Da)
    52,966
  • Last updated
    2022-05-25 v3
  • Checksum
    07F891B9515BC1B6
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSEAAETLSPSQNKTDSTTTSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR

Q8N149-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 419-436: EAAETLSPSQNKTDSTTT → A

Q8N149-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 12-23: Missing
    • 436-483: TSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR → SE

Q8N149-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 436-483: TSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR → SE

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A8MZH0A8MZH0_HUMANLILRA2454
A0A0D9SFC7A0A0D9SFC7_HUMANLILRA2203
A0A0G2JMC9A0A0G2JMC9_HUMANLILRA2490
A0A0G2JMR2A0A0G2JMR2_HUMANLILRA2327
A0A0G2JMW8A0A0G2JMW8_HUMANLILRA2454
E9PDF4E9PDF4_HUMANLILRA2327
A0A087WT41A0A087WT41_HUMANLILRA285

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_05708512-23in isoform 3
Alternative sequenceVSP_008455419-436in isoform 2
Alternative sequenceVSP_057086436-483in isoform 3 and isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF025531
EMBL· GenBank· DDBJ
AAB87665.1
EMBL· GenBank· DDBJ
mRNA
EU915609
EMBL· GenBank· DDBJ
ACK56075.1
EMBL· GenBank· DDBJ
mRNA
EU915610
EMBL· GenBank· DDBJ
ACK56076.1
EMBL· GenBank· DDBJ
mRNA
BC017412
EMBL· GenBank· DDBJ
AAH17412.1
EMBL· GenBank· DDBJ
mRNA
BC027916
EMBL· GenBank· DDBJ
AAH27916.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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