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Entry version 119 (07 Apr 2021)
Sequence version 1 (01 Oct 2002)
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Protein

Oleoyl-[acyl-carrier-protein] hydrolase

Gene

FASN2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processFatty acid biosynthesisARBA annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
drome-CG3524, Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oleoyl-[acyl-carrier-protein] hydrolaseARBA annotation (EC:3.1.2.14ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FASN2Imported
Synonyms:v(2)k05816Imported
ORF Names:CG3524Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0042627, FASN2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1180O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q8MR70

PRoteomics IDEntifications database

More...
PRIDEi
Q8MR70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0042627, Expressed in adult organism and 21 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q8MR70, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1145 – 1222CarrierInterPro annotationAdd BLAST78

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_31_7_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
1.10.1470.20, 1 hit
3.10.129.110, 1 hit
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR013149, ADH_C
IPR023102, Fatty_acid_synthase_dom_2
IPR011032, GroES-like_sf
IPR036291, NAD(P)-bd_dom_sf
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR001031, Thioesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00107, ADH_zinc_N, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00829, PKS_ER, 1 hit
SM00823, PKS_PP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF53474, SSF53474, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50075, CARRIER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q8MR70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LSVELDLGKE ENVYLAGHTI DGRVLFPATG YMTLAWMSLA QQQGLDYLRT
60 70 80 90 100
PVLFEDVVFH RATILSVGTV VKLTLNFFPG SSSFEICEGT SLVTSGKIRL
110 120 130 140 150
VSNVQQEQLQ LSSLPGIAGS NKLSTKDIYK ELRLRGYDYT GVFQGILESD
160 170 180 190 200
ISAVTGQLQW ADNWISFMDT MLQFRILSND IRELYVPTGI ERALIDPLKH
210 220 230 240 250
LELAKKHQQK LTVNWHRNIS VVKCGGVEIH KMKTAQTQRR SGGQSPPSLE
260 270 280 290 300
RYRFWPHSQH LGQREEQEKS RSTALAVAIQ LIIENSGGAV KLKGVELAGS
310 320 330 340 350
RSTLDALSAV QLLELIEREP ILVGDMAVVT SSSNESELGE QLKEHGIRVI
360 370 380 390 400
VKDIKAGAVE QQCHFVYSVN MLAQNSVKDL QHCLDSLKSD SGFLLLEEAA
410 420 430 440 450
SRYNIIGKEK LNKLKLVSVL EQFFGTDRVL VLVRKLSKVQ SSQALTLHLT
460 470 480 490 500
NKQFKWVNEL KNSIAKAQAE EKNLYLVAQG EPNSGALGLM NCLKREAGGH
510 520 530 540 550
FLRLYLILDE GVPQFSLDDP FYAAQLAKDL VVNVYRNGSW GSYRHLKMES
560 570 580 590 600
RPPMLPVEQA YVNTLVKGDL SSLRWIESPR SSPIQSQLEP CTVYYAPLNF
610 620 630 640 650
RDVMLASGKL GVDALPGDLA YQDCVLGLEF AGRDSCGRRV MAMVTAKSLA
660 670 680 690 700
TNCLANRNLL WEVPSKWTME QASTVPCVYA TVYYALVVRG QMKEGERILI
710 720 730 740 750
HAGSGGVGQA AISVALAHGL TVFTTVGSKE KREFLLKRFP KLKAKNIGNS
760 770 780 790 800
RDTSFEQLIM SETHGNGVEL VLNSLSEEKL QASIRCLALN GRFLEIGKFD
810 820 830 840 850
LSNNTPLGMS VFLKNTSFHG ILLDSVMEGE EEMQLMVAKL VAEGIKSGAV
860 870 880 890 900
QPLPTTVFAE QEIEKAFRFM ASGKHIGKVV IKVRLEEEQQ AALPRLRQIQ
910 920 930 940 950
AIPRSYMHPE KSYILVGGLG GFGLELANWL VSRGARFLVL SSRSGVKSGY
960 970 980 990 1000
QALMIRRWHD RGVQVQIDTN DVTTAVGCQR LLEVSNKLAL VGGIFNLAAV
1010 1020 1030 1040 1050
LRDGLIEDQS PKNFEKVSAP KLLATIHLDK ISREICPALE YFVCFSSLSC
1060 1070 1080 1090 1100
GRGNMGQTNY GLANSTMERI CEQRQEYGYP GTAIQWGAIG DTGLIIEHMG
1110 1120 1130 1140 1150
NNETVVGGTL PQRMISCLET LDLFLQQPHP VMASMVVAEK RKTEQANRLS
1160 1170 1180 1190 1200
LIATIANIMG LRDVKSVSDK TTLFDLGMDS LMSTEIKQTL ERHFDLVLSA
1210 1220 1230 1240 1250
QEIRQLTFSA LRQIDAQEPP SASVSSPSAS STLSRIKEEA CVEVQPQSDE
1260 1270 1280 1290 1300
TRKVFAKEVL PQEVMVRLRS KAPVASEDPA VFFLAPIEGF TIAVEALAAS
1310 1320 1330 1340 1350
LTCPAYGLQC TEQVPLDSIE ACAAYYLRQI QKLQPLGPYH IVGYSYGCLL
1360 1370 1380 1390 1400
AHAIAVALEQ RRFGVKVIML DGAPTMASGY VQEAKKQTDD LNRQQSMTLA
1410 1420 1430 1440 1450
YFGALLADVD YNQLLQLLDG VQTWPSKLDK LADTLAGYTQ QTREVIKKAA
1460 1470 1480 1490 1500
CMFKQKLLLS ESYKGAKQLH SDVVLIKSAE HNAIMAQDYG LKEICSAQID
1510 1520
MHVVEGTHRT FLKEPHTLQI IERVLRKRP
Length:1,529
Mass (Da):169,228
Last modified:October 1, 2002 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F305327E39CD188
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY122087 mRNA Translation: AAM52599.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0077657; FBpp0077342; FBgn0042627

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY122087 mRNA Translation: AAM52599.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

ESTHERidrome-CG3524, Thioesterase

Proteomic databases

PeptideAtlasiQ8MR70
PRIDEiQ8MR70

Genome annotation databases

EnsemblMetazoaiFBtr0077657; FBpp0077342; FBgn0042627

Organism-specific databases

FlyBaseiFBgn0042627, FASN2

Phylogenomic databases

HOGENOMiCLU_000022_31_7_1

Gene expression databases

BgeeiFBgn0042627, Expressed in adult organism and 21 other tissues
ExpressionAtlasiQ8MR70, baseline and differential

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
1.10.1470.20, 1 hit
3.10.129.110, 1 hit
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR013149, ADH_C
IPR023102, Fatty_acid_synthase_dom_2
IPR011032, GroES-like_sf
IPR036291, NAD(P)-bd_dom_sf
IPR020807, PKS_dehydratase
IPR042104, PKS_dehydratase_sf
IPR020843, PKS_ER
IPR013968, PKS_KR
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR001031, Thioesterase
PfamiView protein in Pfam
PF00107, ADH_zinc_N, 1 hit
PF08659, KR, 1 hit
PF00550, PP-binding, 1 hit
PF14765, PS-DH, 1 hit
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00829, PKS_ER, 1 hit
SM00823, PKS_PP, 1 hit
SUPFAMiSSF47336, SSF47336, 1 hit
SSF50129, SSF50129, 1 hit
SSF51735, SSF51735, 2 hits
SSF53474, SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS50075, CARRIER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ8MR70_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q8MR70
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 7, 2021
This is version 119 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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