Q8MIT8 · CXB2_MACMU

Function

function

Structural component of gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.

Features

Showing features for binding site.

122620406080100120140160180200220
TypeIDPosition(s)Description
Binding site42Ca2+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site45Ca2+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site47Ca2+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentconnexin complex
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functiongap junction channel activity
Biological Processcell-cell signaling
Biological Processgap junction-mediated intercellular transport
Biological Processsensory perception of sound

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Gap junction beta-2 protein
  • Alternative names
    • Connexin-26 (Cx26)

Gene names

    • Name
      GJB2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    Q8MIT8

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Note: Colocalizes with GJB4 at gap junction plaques in the cochlea.

Features

Showing features for intramembrane, topological domain, transmembrane.

TypeIDPosition(s)Description
Intramembrane2-13
Topological domain14-20Cytoplasmic
Transmembrane21-40Helical
Topological domain41-73Extracellular
Transmembrane74-94Helical
Topological domain95-135Cytoplasmic
Transmembrane136-156Helical
Topological domain157-189Extracellular
Transmembrane190-210Helical
Topological domain211-226Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00000578571-226Gap junction beta-2 protein
Disulfide bond53↔180
Disulfide bond60↔174
Disulfide bond64↔169

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

A hemichannel or connexon is composed of a hexamer of connexins. A functional gap junction is formed by the apposition of two hemichannels (By similarity).
Forms heteromeric channels with GJB4. Interacts with CNST (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    26,224
  • Last updated
    2002-10-01 v1
  • Checksum
    1F4BAC3BB20D0528
MDWGALQTILGGVNKYSTSIGKIWLTVLFIFRIMILVVAAKEVWGDEQADFVCNTLQPGCKNVCYDHYFPISHIRLWALQLIFVSTPALLVAMHVAYRRHEKKRKFIKGEIKNEFKDIEEIKTQKVRIEGSLWWTYTSSIFFRVVFEAAFMYVFYVMYDGFSMQRLVKCNAWPCPNTVDCFVSRPTEKTVFTVFMIAVSGICILLNVTELCYLLIRYCSGKSKKPV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY046584
EMBL· GenBank· DDBJ
AAL03976.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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