Q7N0C3 · HLDE_PHOLL

Function

function

Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.

Catalytic activity

Pathway

Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.
Bacterial outer membrane biogenesis; LPS core biosynthesis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site195-198ATP (UniProtKB | ChEBI)
Active site264

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00356UER00437
    • UPA00356UER00439
    • UPA00958

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      hldE
    • Synonyms
      rfaE
    • Ordered locus names
      plu3968

Organism names

Accessions

  • Primary accession
    Q7N0C3

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000801171-474Bifunctional protein HldE

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-318Ribokinase
Region344-474Cytidylyltransferase

Sequence similarities

In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
In the C-terminal section; belongs to the cytidylyltransferase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    474
  • Mass (Da)
    51,130
  • Last updated
    2003-12-15 v1
  • Checksum
    DC4C4E30D10E862D
MKMTLPDFHCAEVLVVGDVMLDRYWYGPTSRISPEAPVPVVKVNTIEERPGGAANVAMNIAALGANSHLIGLTGIDDAAHALSEKLRSVKVRCDFVSVPTHPTVTKLRVLSRNQQLIRLDFEEGFDNVDAQPMFERIEQALPHIGALVLSDYAKGALSQVQEMIKLANAAKVPVLIDPKGNDFERYRGATLLTPNLSEFEAVVGHCKDDNELVEKGTRLVKGLDLQALLITRSEQGMSLLSVDQPPLHLPTQAQEVFDVTGAGDTVIGVLATAIAAGKPLNEACFLANAAAGVVVGKLGTSTVSPIELENAIRGRAETGFGVMTEFQLKQAVVDARQRGERVVMTNGCFDILHAGHVSYLENARRLGDRLIVAVNSDASTKRLKGESRPVNPLEQRMIVLSALGAVDWVVPFEEDTPQRLIADVLPDVLVKGGDYKPEEIAGSEEVWAAGGDVKVLNFEDGISTTNIIKAIKNQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX571872
EMBL· GenBank· DDBJ
CAE16340.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp