Q7A3E1 · CRTM_STAAN

Function

function

Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the head-to-head condensation of two molecules of farnesyl diphosphate (FPP) into the colorless C30 carotenoid 4,4'-diapophytoene (dehydrosqualene).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Carotenoid biosynthesis; staphyloxanthin biosynthesis; staphyloxanthin from farnesyl diphosphate: step 1/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site18-21(2E,6E)-farnesyl diphosphate 1 (UniProtKB | ChEBI)
Binding site41(2E,6E)-farnesyl diphosphate 1 (UniProtKB | ChEBI)
Binding site45(2E,6E)-farnesyl diphosphate 1 (UniProtKB | ChEBI)
Binding site45(2E,6E)-farnesyl diphosphate 2 (UniProtKB | ChEBI)
Binding site48Mg2+ 1 (UniProtKB | ChEBI)
Binding site52Mg2+ 1 (UniProtKB | ChEBI)
Binding site165(2E,6E)-farnesyl diphosphate 2 (UniProtKB | ChEBI)
Binding site168Mg2+ 2 (UniProtKB | ChEBI)
Binding site171(2E,6E)-farnesyl diphosphate 1 (UniProtKB | ChEBI)
Binding site172Mg2+ 2 (UniProtKB | ChEBI)
Binding site248(2E,6E)-farnesyl diphosphate 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionfarnesyl-diphosphate farnesyltransferase activity
Molecular Functionfarnesyltranstransferase activity
Molecular Functiongeranylgeranyl-diphosphate geranylgeranyltransferase activity
Molecular Functionmetal ion binding
Biological Processcarotenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4,4'-diapophytoene synthase
  • EC number
  • Short names
    DAP synthase
  • Alternative names
    • C30 carotenoid synthase
    • Dehydrosqualene synthase

Gene names

    • Name
      crtM
    • Ordered locus names
      SA2349

Organism names

Accessions

  • Primary accession
    Q7A3E1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002826211-2874,4'-diapophytoene synthase

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    287
  • Mass (Da)
    34,217
  • Last updated
    2004-07-05 v1
  • Checksum
    E5CE311E3B76A452
MTMMDMNFKYCHKIMKKHSKSFSYAFDLLPEDQRKAVWAIYAVCRKIDDSIDVYGDIQFLNQIKEDIQSIEKYPYEHHHFQSDRRIMMALQHVAQHKNIAFQSFYNLIDTVYKDQHFTMFETDAELFGYCYGVAGTVGEVLTPILSDHETHQTYDVARRLGESLQLINILRDVGEDFDNERVYFSKQRLKQYEVDIAEVYQNGVNNHYIDLWEYYAAIAEKDFQDVMDQIKVFSIEAQPIIELAARIYIEILDEVRQANYTLHERVFVDKRKKAKLFHEINSKYHRI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000018
EMBL· GenBank· DDBJ
BAB43653.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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