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Entry version 82 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

PE-PGRS family protein PE_PGRS30

Gene

PE_PGRS30

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates suppression of proinflammatory immune response in macrophages via modulation of host cytokine response (PubMed:27129781). Required for full virulence. Involved in inhibition of phago-lysosome fusion (PubMed:22050772).2 Publications

Miscellaneous

Infection of human THP-1 macrophages with M.smegmatis expressing PE_PGRS30 results in reduced production of IL-12, TNF-alpha and IL-6, as compared to infection with vector control M.smegmatis. No differential effects are observed on bacterial persistence inside macrophages or on macrophage mortality upon infection (PubMed:27129781). However, expression of this gene in M.smegmatis is sufficient to enhance the ability to persist intracellularly and induce murine J774 macrophages death (PubMed:22050772). Differential response of the human and murine macrophages could be due to cell-specific processes (Probable).1 Publication2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-5841-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PE-PGRS family protein PE_PGRS30Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PE_PGRS30Imported
Ordered Locus Names:Rv1651cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1651c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell wall, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Deletion mutant is attenuated in vivo during murine tuberculosis, specifically during the chronic steps of infection. On day 28 post infection, shows a slight reduction of the bacterial burden. On day 70, shows a strong reduction of the bacterial burden. Mice infected with the mutant show smaller, non-confluent tubercules. Mutant shows impaired ability to survive and multiply within murine macrophages. It is unable to inhibit phago-lysosome fusion in THP-1 cells.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_50042877251 – 1011PE-PGRS family protein PE_PGRS30Add BLAST1011

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q79FL8

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1651c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q79FL8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 93PESequence analysis1 PublicationAdd BLAST93

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni130 – 696PGRS domain1 PublicationAdd BLAST567
Regioni697 – 1011C-terminal domain1 PublicationAdd BLAST315

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi114 – 707Gly-richPROSITE-ProRule annotationAdd BLAST594
Compositional biasi895 – 929Ala-richPROSITE-ProRule annotationAdd BLAST35

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both the PE domain and the non-PGRS C-terminal domain possess independent cell wall localization signals. The PGRS domain is responsible for polar localization of PE_PGRS30 (PubMed:24530527, PubMed:25390359). PE and PGRS domains are necessary for the cytokine-modulating function (PubMed:27129781). The non-PGRS C-terminal domain is not exposed on the surface and is not required for full virulence in vivo (PubMed:22050772, PubMed:25390359).4 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mycobacterial PE family. PGRS subfamily.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000286061

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLCERTH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000084 PE-PGRS_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00934 PE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q79FL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLLVEPDL VTAAAANLAG IRSALSEAAA AASTPTTALA SAGADEVSAA
60 70 80 90 100
VSRLFGAYGQ QFQALNARAA TFHAEFVSLL NGGAAAYTGA EAASVSSMQA
110 120 130 140 150
LLDAVNAPTQ TLLGRPLIGN GADGVAGTGS NAGGNGGPGG ILYGNGGNGG
160 170 180 190 200
AGGNGGAAGL IGNGGAGGAG GAGGAGGAGG AGGTGGLLYG NGGAGGNGGS
210 220 230 240 250
AAAAGGAGGN ALLFGNGGNG GSGASGGAAG HAGTIFGNGG NAGAGSGLAG
260 270 280 290 300
ADGGLFGNGG DGGSSTSKAG GAGGNALFGN GGDGGSSTVA AGGAGGNTLV
310 320 330 340 350
GNGGAGGAGG TSGLTGSGVA GGAGGSVGLW GSGGAGGDGG AATSLLGVGM
360 370 380 390 400
NAGAGGAGGN AGLLYGNGGA GGAGGNGGDT TVPLFDSGVG GAGGAGGNAS
410 420 430 440 450
LFGNGGTGGV GGKGGTSSDL ASATSGAGGA GGAGGVGGLL YGNGGNGGAG
460 470 480 490 500
GIGGAAINIL ANAGAGGAGG AAGSSFIGNG GNGGAGGAGG AAALFSSGVG
510 520 530 540 550
GAGGSGGTAL LLGSGGAGGN GGTGGANSGS LFASPGGTGG AGGHGGAGGL
560 570 580 590 600
IWGNGGAGGN GGNGGTTADG ALEGGTGGIG GTGGSAIAFG NGGQGGAGGT
610 620 630 640 650
GGDHSGGNGI GGKGGASGNG GNAGQVFGDG GTGGTGGAGG AGSGTKAGGT
660 670 680 690 700
GSDGGHGGNA TLIGNGGDGG AGGAGGAGSP AGAPGNGGTG GTGGVLFGQS
710 720 730 740 750
GSSGPPGAAA LAFPSLSSSV PILGPYEDLI ANTVANLASI GNTWLADPAP
760 770 780 790 800
FLQQYLANQF GYGQLTLTAL TDATRDFAIG LAGIPPSLQS ALQALAAGDV
810 820 830 840 850
SGAVTDVLGA VVKVFVSGVD ASDLSNILLL GPVGDLFPIL SIPGAMSQNF
860 870 880 890 900
TNVVMTVTDT TIAFSIDTTN LTGVMTFGLP LAMTLNAVGS PITTAIAFAE
910 920 930 940 950
STTAFVSAVQ AGNLQAAAAA LVGAPANVAN GFLNGEARLP LALPTSATGG
960 970 980 990 1000
IPVTVEVPVG GILAPLQPFQ ATAVIPVIGP VTVTLEGTPA GGIVPALVNY
1010
APTQLAQAIA P
Length:1,011
Mass (Da):88,455
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F2CBAB67969E066
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44416.1

NCBI Reference Sequences

More...
RefSeqi
WP_010886125.1, NZ_KK339370.1
YP_177826.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP44416; CCP44416; Rv1651c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
885174

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1651c
mtv:RVBD_1651c

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|83332.111.peg.1836

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44416.1
RefSeqiWP_010886125.1, NZ_KK339370.1
YP_177826.1, NC_000962.3

3D structure databases

SMRiQ79FL8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1651c

Proteomic databases

PaxDbiQ79FL8

Genome annotation databases

EnsemblBacteriaiCCP44416; CCP44416; Rv1651c
GeneIDi885174
KEGGimtu:Rv1651c
mtv:RVBD_1651c
PATRICifig|83332.111.peg.1836

Organism-specific databases

TubercuListiRv1651c

Phylogenomic databases

HOGENOMiHOG000286061
OMAiCLCERTH

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5841-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR000084 PE-PGRS_N
PfamiView protein in Pfam
PF00934 PE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPG30_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q79FL8
Secondary accession number(s): I6X1W4, L0T7B2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 82 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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