Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 116 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Plectin 10

Gene

Plec

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Plectin 10Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PlecImported
Synonyms:Plec1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277961, Plec

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6S385

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6S385

PeptideAtlas

More...
PeptideAtlasi
Q6S385

PRoteomics IDEntifications database

More...
PRIDEi
Q6S385

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6S385

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6S385, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6S385, 4 interactors

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 152Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini165 – 270Calponin-homology (CH)InterPro annotationAdd BLAST106
Domaini808 – 865SH3InterPro annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1485 – 1512DisorderedSequence analysisAdd BLAST28
Regioni1660 – 1694DisorderedSequence analysisAdd BLAST35
Regioni1959 – 2000DisorderedSequence analysisAdd BLAST42
Regioni2083 – 2176DisorderedSequence analysisAdd BLAST94
Regioni2534 – 2587DisorderedSequence analysisAdd BLAST54
Regioni3171 – 3197DisorderedSequence analysisAdd BLAST27
Regioni4246 – 4279DisorderedSequence analysisAdd BLAST34
Regioni4477 – 4550DisorderedSequence analysisAdd BLAST74

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili655 – 689Sequence analysisAdd BLAST35
Coiled coili728 – 755Sequence analysisAdd BLAST28
Coiled coili761 – 784Sequence analysisAdd BLAST24
Coiled coili866 – 886Sequence analysisAdd BLAST21
Coiled coili1102 – 1122Sequence analysisAdd BLAST21
Coiled coili1126 – 1146Sequence analysisAdd BLAST21
Coiled coili1150 – 1170Sequence analysisAdd BLAST21
Coiled coili1242 – 1265Sequence analysisAdd BLAST24
Coiled coili1276 – 1296Sequence analysisAdd BLAST21
Coiled coili1524 – 1569Sequence analysisAdd BLAST46
Coiled coili1593 – 1648Sequence analysisAdd BLAST56
Coiled coili1846 – 1937Sequence analysisAdd BLAST92
Coiled coili2260 – 2367Sequence analysisAdd BLAST108
Coiled coili2372 – 2420Sequence analysisAdd BLAST49
Coiled coili2435 – 2486Sequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1664 – 1694PolyampholyteSequence analysisAdd BLAST31
Compositional biasi2083 – 2124PolyampholyteSequence analysisAdd BLAST42
Compositional biasi2551 – 2587PolyampholyteSequence analysisAdd BLAST37
Compositional biasi3172 – 3186PolyampholyteSequence analysisAdd BLAST15
Compositional biasi4246 – 4276PolarSequence analysisAdd BLAST31
Compositional biasi4477 – 4534PolarSequence analysisAdd BLAST58

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the plakin or cytolinker family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.90.1290.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR030269, Plectin
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 3 hits
PTHR23169:SF20, PTHR23169:SF20, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF00681, Plectin, 18 hits
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00250, PLEC, 35 hits
SM00150, SPEC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6S385-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTWAAKGV FTSQREVLLE RPCWLDGGCE QVRRGYLYGQ LCCVDERDRV
60 70 80 90 100
QKKTFTKWVN KHLIKAQRHI SDLYEDLRDG HNLISLLEVL SGDSLPREKG
110 120 130 140 150
RMRFHKLQNV QIALDYLRHR QVKLVNIRND DIADGNPKLT LGLIWTIILH
160 170 180 190 200
FQISDIQVSG QSEDMTAKEK LLLWSQRMVE GYQGLRCDNF TTSWRDGRLF
210 220 230 240 250
NAIIHRHKPM LIDMNKVYRQ TNLENLDQAF SVAERDLGVT RLLDPEDVDV
260 270 280 290 300
PQPDEKSIIT YVSSLYDAMP RVPGAQDGVR ANELQLRWQE YRELVLLLLQ
310 320 330 340 350
WIRHHTAAFE ERKFPSSFEE IEILWCQFLK FKETELPAKE ADKNRSKVIY
360 370 380 390 400
QSLEGAVQAG QLKIPPGYHP LDVEKEWGKL HVAILEREKQ LRSEFERLEC
410 420 430 440 450
LQRIVSKLQM EAGLCEEQLN QADALLQSDI RLLASGKVAQ RAGEVERDLD
460 470 480 490 500
KADGMIRLLF NDVQTLKDGR HPQGEQMYRR VYRLHERLVA IRTEYNLRLK
510 520 530 540 550
AGVGAPVTQV TLQSTQRRPE LEDSTLRYLQ DLLAWVEENQ RRIDSAEWGV
560 570 580 590 600
DLPSVEAQLG SHRGMHQSIE EFRAKIERAR NDESQLSPAT RGAYRDCLGR
610 620 630 640 650
LDLQYAKLLN SSKARLRSLE SLHGFVAAAT KELMWLNEKE EEEVGFDWSD
660 670 680 690 700
RNTNMAAKKE SYSALMRELE MKEKKIKEIQ NTGDRLLRED HPARPTVESF
710 720 730 740 750
QAALQTQWSW MLQLCCCIEA HLKENTAYFQ FFSDVREAEE QLQKLQETLR
760 770 780 790 800
RKYSCDRTIT VTRLEDLLQD AQDEKEQLNE YKGHLSGLAK RAKAIVQLKP
810 820 830 840 850
RNPAHPVRGH VPLIAVCDYK QVEVTVHKGD QCQLVGPAQP SHWKVLSGSS
860 870 880 890 900
SEAAVPSVCF LVPPPNQEAQ EAVARLEAQH QALVTLWHQL HVDMKSLLAW
910 920 930 940 950
QSLSRDIQLI RSWSLVTFRT LKPEEQRQAL RNLELHYQAF LRDSQDAGGF
960 970 980 990 1000
GPEDRLVAER EYGSCSRHYQ QLLQSLEQGE QEESRCQRCI SELKDIRLQL
1010 1020 1030 1040 1050
EACETRTVHR LRLPLDKDPA RECAQRIAEQ QKAQAEVEGL GKGVARLSAE
1060 1070 1080 1090 1100
AEKVLALPEP SPAAPTLRSE LELTLGKLEQ VRSLSAIYLE KLKTISLVIR
1110 1120 1130 1140 1150
STQGAEEVLK THEEQLKEAQ AVPATLQELE ATKASLKKLR AQAEAQQPVF
1160 1170 1180 1190 1200
NTLRDELRGA QEVGERLQQR HGERDVEVER WRERVTQLLE RWQAVLAQTD
1210 1220 1230 1240 1250
VRQRELEQLG RQLRYYRESA DPLSAWLQDA KRRQEQIQAV PIANCQAARE
1260 1270 1280 1290 1300
QLRQEKALLE EIERHGEKVE ECQKFAKQYI NAIKDYELQL ITYKAQLEPV
1310 1320 1330 1340 1350
ASPAKKPKVQ SGSESVIQEY VDLRTRYSEL TTLTSQYIKF ISETLRRMEE
1360 1370 1380 1390 1400
EERLAEQQRA EERERLAEVE AALEKQRQLA EAHAQAKAQA ELEAQELQRR
1410 1420 1430 1440 1450
MQEEVARREE AAVDAQQQKR SIQEELQHLR QSSEAEIQAK AQQVEAAERS
1460 1470 1480 1490 1500
RMRIEEEIRV VRLQLETTER QRGGAEGELQ ALRARAEEAE AQKRQAQEEA
1510 1520 1530 1540 1550
ERLRRQVQDE SQRKRQAEAE LALRVKAEAE AAREKQRALQ ALDELRLQAE
1560 1570 1580 1590 1600
EAERRLRQAE AERARQVQVA LETAQRSAEV ELQSKRASFA EKTAQLERTL
1610 1620 1630 1640 1650
QEEHVTVAQL REEAERRAQQ QAEAERAREE AERELERWQL KANEALRLRL
1660 1670 1680 1690 1700
QAEEVAQQKS LAQADAEKQK EEAEREARRR GKAEEQAVRQ RELAEQELEK
1710 1720 1730 1740 1750
QRQLAEGTAQ QRLAAEQELI RLRAETEQGE QQRQLLEEEL ARLQHEATAA
1760 1770 1780 1790 1800
TQKRQELEAE LAKVRAEMEV LLASKARAEE ESRSTSEKSK QRLEAEAGRF
1810 1820 1830 1840 1850
RELAEEAARL RALAEEAKRQ RQLAEEDAAR QRAEAERVLT EKLAAISEAT
1860 1870 1880 1890 1900
RLKTEAEIAL KEKEAENERL RRLAEDEAFQ RRRLEEQAAL HKADIEERLA
1910 1920 1930 1940 1950
QLRKASESEL ERQKGLVEDT LRQRRQVEEE IMALKVSFEK AAAGKAELEL
1960 1970 1980 1990 2000
ELGRIRSNAE DTMRSKEQAE LEAARQRQLA AEEEQRRREA EERVQRSLAA
2010 2020 2030 2040 2050
EEEAARQRKV ALEEVERLKA KVEEARRLRE RAEQESARQL QLAQEAAQKR
2060 2070 2080 2090 2100
LQAEEKAHAF VVQQREEELQ QTLQQEQNML DRLRSEAEAA RRAAEEAEEA
2110 2120 2130 2140 2150
REQAEREAAQ SRKQVEEAER LKQSAEEQAQ AQAQAQAAAE KLRKEAEQEA
2160 2170 2180 2190 2200
ARRAQAEQAA LKQKQAADAE MEKHKKFAEQ TLRQKAQVEQ ELTTLRLQLE
2210 2220 2230 2240 2250
ETDHQKSILD EELQRLKAEV TEAARQRSQV EEELFSVRVQ MEELGKLKAR
2260 2270 2280 2290 2300
IEAENRALIL RDKDNTQRFL EEEAEKMKQV AEEAARLSVA AQEAARLRQL
2310 2320 2330 2340 2350
AEEDLAQQRA LAEKMLKEKM QAVQEATRLK AEAELLQQQK ELAQEQARRL
2360 2370 2380 2390 2400
QEDKEQMAQQ LVEETQGFQR TLEAERQRQL EMSAEAERLK LRMVEMSRAQ
2410 2420 2430 2440 2450
ARAEEDAQRF RKQAEEIGEK LHRTELATQE KVTLVQTLEI QRQQSDHDAE
2460 2470 2480 2490 2500
RLREAIAELE REKEKLKQEA KLLQLKSEEM QTVQQEQILQ ETQALQKSFL
2510 2520 2530 2540 2550
SEKDSLLQRE RFIEQEKAKL EQLFQDEVAK AKQLREEQQR QQQQMEQEKQ
2560 2570 2580 2590 2600
ELMASMEEAR RRQREAEEGV RRKQEELQHL EQQRQQQEKL LAEENQRLRE
2610 2620 2630 2640 2650
RLQRLEEEHR AALAHSEIAT TQAASTKALP NGRDAPDGPS VEAEPEYTFE
2660 2670 2680 2690 2700
GLRQKVPAQQ LQEAGILSQE ELQRLAQGHT TVAELTQRED VYRYLKGRSS
2710 2720 2730 2740 2750
IAGLLLKPTN EKLSVYTALQ RQLLSPGTAL ILLEAQAASG FLLDPVRNRR
2760 2770 2780 2790 2800
LTVNEAVKEG VVGPELHHKL LSAERAVTGY KDPYTGEQIS LFQAMKKDLI
2810 2820 2830 2840 2850
VRDHGVRLLE AQIATGGIID PVHSHRVPVD VAYKRGYFDE EMNRILSDPS
2860 2870 2880 2890 2900
DDTKGFFDPN THENLTYLQL LERCVEDPET GLRLLPLTDK AAKGGELVYT
2910 2920 2930 2940 2950
DTEARDVFEK ATVSAPFGKF QGRTVTIWEI INSEYFTAEQ RRDLLQQFRT
2960 2970 2980 2990 3000
GHITVEKIIK IVITVVEEHE RKGQLCFEGL RALVPAAELL DSGVISHELY
3010 3020 3030 3040 3050
QQLQRGERSV REVAEADSVR QALRGTNVIA GVWLEEAGQK LSIYEALKKD
3060 3070 3080 3090 3100
LLQPEVAVAL LEAQAGTGHI IDPATSARLT VDEAVRAGLV GPELHEKLLS
3110 3120 3130 3140 3150
AEKAVTGYRD PYSGQSVSLF QALKKGLIPR EQGLRLLDAQ LSTGGIVDPS
3160 3170 3180 3190 3200
KSHRVPLDVA YARGYLDKET NRALTSPRDD ARVYHDPSTQ EPVTYSQLQQ
3210 3220 3230 3240 3250
RCRSDQLTGL SLLPLSEKAV RARQEEVYSE LQARETLEQA KVEVPVGSFK
3260 3270 3280 3290 3300
GRAMTVWELI SSEYFTEEQR QELLRQFRTG KVTVEKVIKI VITIVEEVET
3310 3320 3330 3340 3350
RRQERLSFSG LRAPVPASEL LDAKILSRAQ FDQLKDGKTS VKELSEVGSV
3360 3370 3380 3390 3400
RTLLQGSGCL AGIYLEDSKE KVTIYEAMRR GLLRPSTATL LLEAQAATGF
3410 3420 3430 3440 3450
LVDPVRNQRL YVHEAVKAGV VGPELHEKLL SAEKAVTGYK DPYSGNTISL
3460 3470 3480 3490 3500
FQAMKKGLVL RDHAIRLLEA QVATGGIIDP VHSHRLPVDV AYQRGYFDEE
3510 3520 3530 3540 3550
MNRVLADPSD DTKGFFDPNT HENLTYLQLL ERCVEDPETG LRLLPLKGAE
3560 3570 3580 3590 3600
KTEVVETTQV YTEEETRRAF EETQIDIPGG GSHGGSSMSL WEVMQSNMIP
3610 3620 3630 3640 3650
EDQRARLMAD FQAGRVTKER MIIIIIEIIE KTEIIRQQNL ASYDYVRRRL
3660 3670 3680 3690 3700
TAEDLYEARI ISLETYNLFR EGTKNLREVL EMESAWRYLY GTGAVAGVYL
3710 3720 3730 3740 3750
PGSRQTLTIY QALKKGLLSA EVARLLLEAQ AATGFLLDPV KGERLTVDEA
3760 3770 3780 3790 3800
VRKGLVGPEL HDRLLSAERA VTGYRDPYTE QTISLFQAMK KELIPAEEAL
3810 3820 3830 3840 3850
RLLDAQLATG GIVDPRLGFH LPLEVAYQRG YLNKDTHDQL SEPSEVRSYV
3860 3870 3880 3890 3900
DPSTDERLSY TQLLKRCRRD DPSGQMLLLL SDARKLTFRG LRKQITVEEL
3910 3920 3930 3940 3950
VRSQVMDEAT ALQLQEGLTS IEEVTKNLQK FLEGTSCIAG VFVDATKERL
3960 3970 3980 3990 4000
SVYQAMKKGI IRPGTAFELL EAQAATGYVI DPIKGLKLTV EEAVRMGIVG
4010 4020 4030 4040 4050
PEFKDKLLSA ERAVTGYKDP YSGKLISLFQ AMKKGLILKD HGIRLLEAQI
4060 4070 4080 4090 4100
ATGGIIDPEE SHRLPVEVAY KRGLFDEEMN EILTDPSDDT KGFFDPNTEE
4110 4120 4130 4140 4150
NLTYLQLMER CITDPQTGLC LLPLKEKKRE RKTSSKSSVR KRRVVIVDPE
4160 4170 4180 4190 4200
TGKEMSVYEA YRKGLIDHQT YLELSEQECE WEEITISSSD GVVKSMIIDR
4210 4220 4230 4240 4250
RSGRQYDIDD AITKNLIDRS ALDQYRAGTL SITEFADMLS GNAGGFRSRS
4260 4270 4280 4290 4300
SSVGSSSSYP ISSAGPRTQL ASWSDPTEET GPVAGILDTE TLEKVSITEA
4310 4320 4330 4340 4350
MHRNLVDNIT GQRLLEAQAC TGGIIDPSTG ERFPVTEAVN KGLVDKIMVD
4360 4370 4380 4390 4400
RINLAQKAFC GFEDPRTKTK MSAAQALKKG WLYYEAGQRF LEVQYLTGGL
4410 4420 4430 4440 4450
IEPDTPGRVS LDEALQRGTV DARTAQKLRD VSAYSKYLTC PKTKLKISYK
4460 4470 4480 4490 4500
DALDRSMVEE GTGLRLLEAA AQSSKGYYSP YSVSGSGSTA GSRTGSRTGS
4510 4520 4530 4540 4550
RAGSRRGSFD ATGSGFSMTF SSSSYSSSGY GRRYASGPSA SLGGPESAVA
Length:4,550
Mass (Da):518,126
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE72065D99911AC19
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY480042 mRNA Translation: AAR95675.1

NCBI Reference Sequences

More...
RefSeqi
NP_958795.2, NM_201393.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18810

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY480042 mRNA Translation: AAR95675.1
RefSeqiNP_958795.2, NM_201393.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ6S385, 4 interactors

PTM databases

SwissPalmiQ6S385

Proteomic databases

EPDiQ6S385
MaxQBiQ6S385
PeptideAtlasiQ6S385
PRIDEiQ6S385

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
18810

Genome annotation databases

GeneIDi18810

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5339
MGIiMGI:1277961, Plec

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18810, 4 hits in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Plec, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ6S385, MM

Family and domain databases

CDDicd00014, CH, 2 hits
Gene3Di1.10.418.10, 2 hits
3.90.1290.10, 6 hits
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR043197, Plakin
IPR035915, Plakin_repeat_sf
IPR030269, Plectin
IPR001101, Plectin_repeat
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
PANTHERiPTHR23169, PTHR23169, 3 hits
PTHR23169:SF20, PTHR23169:SF20, 3 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF00681, Plectin, 18 hits
PF17902, SH3_10, 1 hit
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00250, PLEC, 35 hits
SM00150, SPEC, 6 hits
SUPFAMiSSF47576, SSF47576, 1 hit
SSF75399, SSF75399, 7 hits
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS50002, SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6S385_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6S385
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again