Q6PH37 · ST1S1_DANRE
- ProteinCytosolic sulfotransferase 1
- Genesult1st1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids299 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a variety of xenobiotic and endogenous compounds, including 2-naphthol, hydroxychlorobiphenyls, dopamine and T3 (triiodo-L-thyronine).
Activity regulation
Inhibited by Co2+, Zn2+, Cd2+ and Pb2+ ions. Inactivated by Hg2+ and Cu2+ ions.
pH Dependence
Optimum pH is 6.0-9.0.
Temperature Dependence
Thermostable from 20 to 43 degrees Celsius.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 51-56 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: KAGTTW | ||||||
Active site | 113 | Proton acceptor | ||||
Sequence: H | ||||||
Binding site | 135 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 143 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 199 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 233-238 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: VQFDAM | ||||||
Binding site | 261-263 | 3'-phosphoadenylyl sulfate (UniProtKB | ChEBI) | ||||
Sequence: RKG |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | aryl sulfotransferase activity | |
Molecular Function | sulfotransferase activity | |
Biological Process | catecholamine metabolic process | |
Biological Process | sulfation | |
Biological Process | xenobiotic metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytosolic sulfotransferase 1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ6PH37
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085173 | 1-299 | Cytosolic sulfotransferase 1 | |||
Sequence: MDIPDFSSISSRPTIFEFEGISMINHFTENWEKVKNFQARPDDILIATYPKAGTTWVSYILDLLYFGENAPEEHTSQPIYMRVPFLESCFKVIASGTELADNMTTSPRLIKTHLPVQLIPKSFWEQNSRVVYVARNAKDNVVSYFHFDRMNIVEPDPGDWNTFLHRFMDGKSVFGPWYDHVNGYWEKKQTYSNLLYLFYEDLVEDTGREVDRLCSFLGLSTSVSDREKITKDVQFDAMKQNKMTNYSTLPVMDFKISPFMRKGKVGDWKNHFTVAQNEQFDEVYKEKMKNATVKFRTEI |
Proteomic databases
Expression
Tissue specificity
Expressed in liver.
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)35,035
- Last updated2004-07-05 v1
- Checksum805D82915B45EB6A
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 3 | in Ref. 1; AAO64983 | ||||
Sequence: I → M | ||||||
Sequence conflict | 193 | in Ref. 1; AAO64983 | ||||
Sequence: N → T |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY181064 EMBL· GenBank· DDBJ | AAO64983.1 EMBL· GenBank· DDBJ | mRNA | ||
BC056729 EMBL· GenBank· DDBJ | AAH56729.1 EMBL· GenBank· DDBJ | mRNA |