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Entry version 78 (08 May 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Uncharacterized PPE family protein PPE54

Gene

PPE54

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probably plays a role in host phagosome maturation arrest (PubMed:20844580).1 Publication

Miscellaneous

Was identified as a high-confidence drug target.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-7619-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized PPE family protein PPE54
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPE54
Ordered Locus Names:Rv3343c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv3343c

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Grows normally in liquid culture, traffics into host (human and mouse) acidified compartments early after phagocytosis, suggesting it no longer arrests phagosome maturation as well as wild-type, impaired growth in mouse macrophages (PubMed:20844580).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003784861 – 2523Uncharacterized PPE family protein PPE54Add BLAST2523

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6MWY2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv3343c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6MWY2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 186Ala-richAdd BLAST161
Compositional biasi190 – 2192Gly-richAdd BLAST2003
Compositional biasi2436 – 2440Poly-Gly5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the mycobacterial PPE family.Curated

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000043673

Identification of Orthologs from Complete Genome Data

More...
OMAi
DVYIDTH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6MWY2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1260.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002989 Mycobac_pentapep
IPR000030 PPE_family
IPR038332 PPE_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01469 Pentapeptide_2, 16 hits
PF00823 PPE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6MWY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFVVMPPEI NSLLIYTGAG PGPLLAAAAA WDELAAELGS AAAAFGSVTS
60 70 80 90 100
GLVGGIWQGP SSVAMAAAAA PYAGWLSAAA ASAESAAGQA RAVVGVFEAA
110 120 130 140 150
LAETVDPFVI AANRSRLVSL ALSNLFGQNT PAIAAAEFDY ELMWAQDVAA
160 170 180 190 200
MLGYHTGASA AAEALAPFGS PLASLAAAAE PAKSLAVNLG LANVGLFNAG
210 220 230 240 250
SGNVGSYNVG AGNVGSYNVG GGNIGGNNVG LGNVGWGNFG LGNSGLTPGL
260 270 280 290 300
MGLGNIGFGN AGSYNFGLAN MGVGNIGFAN TGSGNFGIGL TGDNLTGFGG
310 320 330 340 350
FNTGSGNVGL FNSGTGNVGF FNSGTGNWGV FNSGSYNTGI GNSGIASTGL
360 370 380 390 400
FNAGGFNTGV VNAGSYNTGS FNAGEANTGG FNPGSVNTGW LNTGDINTGV
410 420 430 440 450
ANSGDVNTGA FISGNYSNGV LWRGDYQGLL GFSSGANVLP VIPLSLDING
460 470 480 490 500
GVGAITIEPI HILPDIPINI NETLYLGPLV VPPINVPAIS LGVGIPNISI
510 520 530 540 550
GPIKINPITL WPAQNFNQTI TLAWPVSSIT IPQIQQVALS PSPIPTTLIG
560 570 580 590 600
PIHINTGFSI PVTFSYSTPA LTLFPVGLSI PTGGPLTLTL GVTAGTEAFT
610 620 630 640 650
IPGFSIPEQP LPLAINVIGH INALSTPAIT IDNIPLNLHA IGGVGPVDIV
660 670 680 690 700
GGNVPASPGF GNSTTAPSSG FFNTGAGGVS GFGNVGAHTS GWFNQSTQAM
710 720 730 740 750
QVLPGTVSGY FNSGTLMSGI GNVGTQLSGM LSGGALGGNN FGLGNIGFDN
760 770 780 790 800
VGFGNAGSSN FGLANMGIGN IGLANTGNGN IGIGLSGDNL TGFGGFNSGS
810 820 830 840 850
ENVGLFNSGT GNVGFFNSGT GNLGVFNSGS HNTGFFLTGN NINVLAPFTP
860 870 880 890 900
GTLFTISEIP IDLQVIGGIG PIHVQPIDIP AFDIQITGGF IGIREFTLPE
910 920 930 940 950
ITIPAIPIHV TGTVGLEGFH VNPAFVLFGQ TAMAEITADP VVLPDPFITI
960 970 980 990 1000
DHYGPPLGPP GAKFPSGSFY LSISDLQING PIIGSYGGPG TIPGPFGATF
1010 1020 1030 1040 1050
NLSTSSLALF PAGLTVPDQT PVTVNLTGGL DSITLFPGGL AFPENPVVSL
1060 1070 1080 1090 1100
TNFSVGTGGF TVFPQGFTVD RIPVDLHTTL SIGPFPFRWD YIPPTPANGP
1110 1120 1130 1140 1150
IPAVPGGFGL TSGLFPFHFT LNGGIGPISI PTTTVVDALN PLLTVTGNLE
1160 1170 1180 1190 1200
VGPFTVPDIP IPAINFGLDG NVNVSFNAPA TTLLSGLGIT GSIDISGIQI
1210 1220 1230 1240 1250
TNIQTQPAQL FMSVGQTLFL FDFRDGIELN PIVIPGSSIP ITMAGLSIPL
1260 1270 1280 1290 1300
PTVSESIPLN FSFGSPASTV KSMILHEILP IDVSINLEDA VFIPATVLPA
1310 1320 1330 1340 1350
IPLNVDVTIP VGPINIPIIT EPGSGNSTTT TSDPFSGLAV PGLGVGLLGL
1360 1370 1380 1390 1400
FDGSIANNLI SGFNSAVGIV GPNVGLSNLG GGNVGLGNVG DFNLGAGNVG
1410 1420 1430 1440 1450
GFNVGGGNIG GNNVGLGNVG FGNVGLANSG LTPGLMGLGN IGFGNAGSYN
1460 1470 1480 1490 1500
FGLANMGVGN IGFANTGSGN FGIGLTGDNL TGFGGFNTGS GNVGLFNSGT
1510 1520 1530 1540 1550
GNVGFFNSGT GNWGVFNSGS YNTGIGNSGI ASTGLFNAGG FNTGVVNAGS
1560 1570 1580 1590 1600
YNTGSFNAGQ ANTGGFNPGS VNTGWLNTGD INTGVANSGD VNTGAFISGN
1610 1620 1630 1640 1650
YSNGAFWRGD YQGLLGFSYR PAVLPQTPFL DLTLTGGLGS VVIPAIDIPA
1660 1670 1680 1690 1700
IRPEFSANVA IDSFTVPSIP IPQIDLAATT VSVGLGPITV PHLDIPRVPV
1710 1720 1730 1740 1750
TLNYLFGSQP GGPLKIGPIT GLFNTPIGLT PLALSQIVIG ASSSQGTITA
1760 1770 1780 1790 1800
FLANLPFSTP VVTIDEIPLL ASITGHSEPV DIFPGGLTIP AMNPLSINLS
1810 1820 1830 1840 1850
GGTGAVTIPA ITIGEIPFDL VAHSTLGPVH ILIDLPAVPG FGNTTGAPSS
1860 1870 1880 1890 1900
GFFNSGAGGV SGFGNVGAMV SGGWNQAPSA LLGGGSGVFN AGTLHSGVLN
1910 1920 1930 1940 1950
FGSGMSGLFN TSVLGLGAPA LVSGLGSVGQ QLSGLLASGT ALHQGLVLNF
1960 1970 1980 1990 2000
GLADVGLGNV GLGNVGDFNL GAGNVGGFNV GGGNIGGNNV GLGNVGWGNF
2010 2020 2030 2040 2050
GLGNSGLTPG LMGLGNIGFG NAGSYNFGLA NMGVGNIGFA NTGSGNFGIG
2060 2070 2080 2090 2100
LTGDNLTGFG GFNTGSGNVG LFNSGTGNVG FFNSGTGNWG VFNSGSYNTG
2110 2120 2130 2140 2150
IGNSGIASTG LFNAGGFNTG VVNAGSYNTG SFNAGQANTG GFNPGSVNTG
2160 2170 2180 2190 2200
WLNTGDINTG VANSGDVNTG AFISGNYSNG AFWRGDYQGL LGFSYTSTII
2210 2220 2230 2240 2250
PEFTVANIHA SGGAGPIIVP SIQFPAIPLD LSATGHIGGF TIPPVSISPI
2260 2270 2280 2290 2300
TVRIDPVFDL GPITVQDITI PALGLDPATG VTVGPIFSSG SIIDPFSLTL
2310 2320 2330 2340 2350
LGFINVNVPA IQTAPSEILP FTVLLSSLGV THLTPEITIP GFHIPVDPIH
2360 2370 2380 2390 2400
VELPLSVTIG PFVSPEITIP QLPLGLALSG ATPAFAFPLE ITIDRIPVVL
2410 2420 2430 2440 2450
DVNALLGPIN AGLVIPPVPG FGNTTAVPSS GFFNIGGGGG LSGFHNLGAG
2460 2470 2480 2490 2500
MSGVLNAISD PLLGSASGFA NFGTQLSGIL NRGADISGVY NTGALGLITS
2510 2520
ALVSGFGNVG QQLAGLIYTG TGP
Length:2,523
Mass (Da):250,346
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD0DADA4040669B3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46164.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F70846

NCBI Reference Sequences

More...
RefSeqi
WP_010886163.1, NC_018143.2
YP_177960.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP46164; CCP46164; Rv3343c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
888033

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv3343c
mtv:RVBD_3343c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP46164.1
PIRiF70846
RefSeqiWP_010886163.1, NC_018143.2
YP_177960.1, NC_000962.3

3D structure databases

SMRiQ6MWY2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3343c

Proteomic databases

PaxDbiQ6MWY2

Genome annotation databases

EnsemblBacteriaiCCP46164; CCP46164; Rv3343c
GeneIDi888033
KEGGimtu:Rv3343c
mtv:RVBD_3343c

Organism-specific databases

TubercuListiRv3343c

Phylogenomic databases

HOGENOMiHOG000043673
OMAiDVYIDTH
PhylomeDBiQ6MWY2

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-7619-MONOMER

Family and domain databases

Gene3Di1.20.1260.20, 1 hit
InterProiView protein in InterPro
IPR002989 Mycobac_pentapep
IPR000030 PPE_family
IPR038332 PPE_sf
PfamiView protein in Pfam
PF01469 Pentapeptide_2, 16 hits
PF00823 PPE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPE54_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6MWY2
Secondary accession number(s): L0TCH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 5, 2004
Last modified: May 8, 2019
This is version 78 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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