P62862 · RS30_MOUSE
- ProteinUbiquitin-like FUBI-ribosomal protein eS30 fusion protein
- GeneFau
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids133 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Ubiquitin-like protein FUBI
May have pro-apoptotic activity.
Small ribosomal subunit protein eS30
Component of the 40S subunit of the ribosome (PubMed:36517592).
Contributes to the assembly and function of 40S ribosomal subunits (By similarity).
Contributes to the assembly and function of 40S ribosomal subunits (By similarity).
Miscellaneous
FAU encodes a fusion protein consisting of the ubiquitin-like protein FUBI at the N terminus and ribosomal protein S30 at the C terminus.
Ubiquitin-like protein FUBI
Lacks the typical lysine residues that participate in Ub's polyubiquitination. However contains a C-terminal di-glycine signature after its proteolytic separation from ribosomal protein S30 and could theoretically be conjugated onto target proteins.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | cytosolic small ribosomal subunit | |
Cellular Component | extracellular space | |
Cellular Component | nucleus | |
Molecular Function | structural constituent of ribosome | |
Biological Process | antibacterial humoral response | |
Biological Process | antimicrobial humoral immune response mediated by antimicrobial peptide | |
Biological Process | cytoplasmic translation | |
Biological Process | defense response to Gram-positive bacterium | |
Biological Process | innate immune response in mucosa |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquitin-like FUBI-ribosomal protein eS30 fusion protein
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP62862
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data), modified residue.
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000457810 | 1-74 | UniProt | Ubiquitin-like protein FUBI | ||
Chain | PRO_0000174000 | 1-133 | UniProt | Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein | ||
Chain | PRO_0000457811 | 75-133 | UniProt | Small ribosomal subunit protein eS30 | ||
Modified residue (large scale data) | 122 | PTMeXchange | Phosphothreonine | |||
Modified residue | 125 | UniProt | N6-succinyllysine | |||
Post-translational modification
FUBI is cleaved from ribosomal protein S30 by the deubiquitinase USP36 before the assembly of ribosomal protein S30 into pre-40S ribosomal particles. FUBI removal from ribosomal protein S30 is a crucial event for the final maturation of pre-40S particles.
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Small ribosomal subunit protein eS30
Component of the 40S subunit of the ribosome.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | P62862 | Bcl2l14 Q9CPT0 | 4 | EBI-309546, EBI-8296066 | |
BINARY | P62862 | Sh3gl1 Q62419 | 3 | EBI-309546, EBI-642935 |
Complex viewer
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 84-110 | Disordered | |||
Compositional bias | 97-110 | Basic residues | |||
Sequence similarities
In the N-terminal section; belongs to the ubiquitin family.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS30 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length133
- Mass (Da)14,416
- Last updated2023-05-03 v2
- MD5 ChecksumA7265D07217E6096184486B5406F0768
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A494B9Z0 | A0A494B9Z0_MOUSE | Fau | 63 | ||
A0A494BBA8 | A0A494BBA8_MOUSE | Fau | 98 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 97-110 | Basic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X65922 EMBL· GenBank· DDBJ | CAA46715.1 EMBL· GenBank· DDBJ | mRNA | ||
D26610 EMBL· GenBank· DDBJ | BAA05655.1 EMBL· GenBank· DDBJ | mRNA | ||
L33715 EMBL· GenBank· DDBJ | AAA91564.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF147745 EMBL· GenBank· DDBJ | AAF80246.1 EMBL· GenBank· DDBJ | mRNA | ||
AK002355 EMBL· GenBank· DDBJ | BAB22034.1 EMBL· GenBank· DDBJ | mRNA | ||
AK008466 EMBL· GenBank· DDBJ | BAB25684.1 EMBL· GenBank· DDBJ | mRNA | ||
AK132752 EMBL· GenBank· DDBJ | BAE21333.1 EMBL· GenBank· DDBJ | mRNA | ||
AK151211 EMBL· GenBank· DDBJ | BAE30206.1 EMBL· GenBank· DDBJ | mRNA | ||
AK151465 EMBL· GenBank· DDBJ | BAE30423.1 EMBL· GenBank· DDBJ | mRNA | ||
AK152738 EMBL· GenBank· DDBJ | BAE31458.1 EMBL· GenBank· DDBJ | mRNA | ||
BC058691 EMBL· GenBank· DDBJ | AAH58691.1 EMBL· GenBank· DDBJ | mRNA | ||
BC062873 EMBL· GenBank· DDBJ | AAH62873.1 EMBL· GenBank· DDBJ | mRNA | ||
BC081463 EMBL· GenBank· DDBJ | AAH81463.1 EMBL· GenBank· DDBJ | mRNA |