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P62862 · RS30_MOUSE

  • Protein
    Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein
  • Gene
    Fau
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Ubiquitin-like protein FUBI

May have pro-apoptotic activity.

Small ribosomal subunit protein eS30

Component of the 40S subunit of the ribosome (PubMed:36517592).
Contributes to the assembly and function of 40S ribosomal subunits (By similarity).

Miscellaneous

FAU encodes a fusion protein consisting of the ubiquitin-like protein FUBI at the N terminus and ribosomal protein S30 at the C terminus.

Ubiquitin-like protein FUBI

Lacks the typical lysine residues that participate in Ub's polyubiquitination. However contains a C-terminal di-glycine signature after its proteolytic separation from ribosomal protein S30 and could theoretically be conjugated onto target proteins.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosolic small ribosomal subunit
Cellular Componentextracellular space
Cellular Componentnucleus
Molecular Functionstructural constituent of ribosome
Biological Processantibacterial humoral response
Biological Processantimicrobial humoral immune response mediated by antimicrobial peptide
Biological Processcytoplasmic translation
Biological Processdefense response to Gram-positive bacterium
Biological Processinnate immune response in mucosa

Keywords

Enzyme and pathway databases

    • R-MMU-156827L13a-mediated translational silencing of Ceruloplasmin expression
    • R-MMU-1799339SRP-dependent cotranslational protein targeting to membrane
    • R-MMU-6791226Major pathway of rRNA processing in the nucleolus and cytosol
    • R-MMU-72649Translation initiation complex formation
    • R-MMU-72689Formation of a pool of free 40S subunits

Names & Taxonomy

Protein names

Gene names

    • Name
      Fau

Organism names

  • Taxonomic identifier
  • Strains
    • SWR/J
    • BALB/cJ
    • Swiss OB
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P62862
  • Secondary accessions
    • P35545
    • Q05472
    • Q642K5
    • Q95261
    • Q9JJ24

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

Type
IDPosition(s)Source
Description
ChainPRO_00004578101-74UniProtUbiquitin-like protein FUBI
ChainPRO_00001740001-133UniProtUbiquitin-like FUBI-ribosomal protein eS30 fusion protein
ChainPRO_000045781175-133UniProtSmall ribosomal subunit protein eS30
Modified residue (large scale data)122PTMeXchangePhosphothreonine
Modified residue125UniProtN6-succinyllysine

Post-translational modification

FUBI is cleaved from ribosomal protein S30 by the deubiquitinase USP36 before the assembly of ribosomal protein S30 into pre-40S ribosomal particles. FUBI removal from ribosomal protein S30 is a crucial event for the final maturation of pre-40S particles.

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Small ribosomal subunit protein eS30

Component of the 40S subunit of the ribosome.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY P62862Bcl2l14 Q9CPT04EBI-309546, EBI-8296066
BINARY P62862Sh3gl1 Q624193EBI-309546, EBI-642935

Complex viewer

View interactors in UniProtKB
View CPX-5261 in Complex Portal

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region84-110Disordered
Compositional bias97-110Basic residues

Sequence similarities

In the N-terminal section; belongs to the ubiquitin family.
In the C-terminal section; belongs to the eukaryotic ribosomal protein eS30 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    133
  • Mass (Da)
    14,416
  • Last updated
    2023-05-03 v2
  • MD5 Checksum
    A7265D07217E6096184486B5406F0768
MQLFVRAQELHTLEVTGQETVAQIKDHVASLEGIAPEDQVVLLAGSPLEDEATLGQCGVEALTTLEVAGRMLGGKVHGSLARAGKVRGQTPKVAKQEKKKKKTGRAKRRMQYNRRFVNVVPTFGKKKGPNANS

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A494B9Z0A0A494B9Z0_MOUSEFau63
A0A494BBA8A0A494BBA8_MOUSEFau98

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias97-110Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X65922
EMBL· GenBank· DDBJ
CAA46715.1
EMBL· GenBank· DDBJ
mRNA
D26610
EMBL· GenBank· DDBJ
BAA05655.1
EMBL· GenBank· DDBJ
mRNA
L33715
EMBL· GenBank· DDBJ
AAA91564.1
EMBL· GenBank· DDBJ
Genomic DNA
AF147745
EMBL· GenBank· DDBJ
AAF80246.1
EMBL· GenBank· DDBJ
mRNA
AK002355
EMBL· GenBank· DDBJ
BAB22034.1
EMBL· GenBank· DDBJ
mRNA
AK008466
EMBL· GenBank· DDBJ
BAB25684.1
EMBL· GenBank· DDBJ
mRNA
AK132752
EMBL· GenBank· DDBJ
BAE21333.1
EMBL· GenBank· DDBJ
mRNA
AK151211
EMBL· GenBank· DDBJ
BAE30206.1
EMBL· GenBank· DDBJ
mRNA
AK151465
EMBL· GenBank· DDBJ
BAE30423.1
EMBL· GenBank· DDBJ
mRNA
AK152738
EMBL· GenBank· DDBJ
BAE31458.1
EMBL· GenBank· DDBJ
mRNA
BC058691
EMBL· GenBank· DDBJ
AAH58691.1
EMBL· GenBank· DDBJ
mRNA
BC062873
EMBL· GenBank· DDBJ
AAH62873.1
EMBL· GenBank· DDBJ
mRNA
BC081463
EMBL· GenBank· DDBJ
AAH81463.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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