Q5Y4N8 · AGRE1_RAT

  • Protein
    Adhesion G protein-coupled receptor E2
  • Gene
    Adgre1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS region of the GAIN-B domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS region.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell periphery
Cellular Componentexternal side of plasma membrane
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular FunctionG protein-coupled receptor activity
Biological Processadaptive immune response
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological Processcell surface receptor signaling pathway
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processcellular response to tumor necrosis factor

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adhesion G protein-coupled receptor E2
  • Alternative names
    • EGF-like module receptor 1
    • EGF-like module-containing mucin-like hormone receptor-like 1
    • EMR1 hormone receptor

Gene names

    • Name
      Adgre1
    • Synonyms
      Emr1

Organism names

  • Taxonomic identifier
  • Strain
    • Brown Norway
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q5Y4N8

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain16-652Extracellular
Transmembrane653-673Helical; Name=1
Topological domain674-681Cytoplasmic
Transmembrane682-702Helical; Name=2
Topological domain703-719Extracellular
Transmembrane720-740Helical; Name=3
Topological domain741-756Cytoplasmic
Transmembrane757-777Helical; Name=4
Topological domain778-795Extracellular
Transmembrane796-816Helical; Name=5
Topological domain817-849Cytoplasmic
Transmembrane850-870Helical; Name=6
Topological domain871-872Extracellular
Transmembrane873-893Helical; Name=7
Topological domain894-932Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_000025095916-932Adhesion G protein-coupled receptor E2
Disulfide bond36↔48
Disulfide bond42↔57
Disulfide bond85↔98
Disulfide bond92↔107
Disulfide bond137↔149
Disulfide bond143↔158
Glycosylation148N-linked (GlcNAc...) asparagine
Disulfide bond160↔171
Glycosylation167N-linked (GlcNAc...) asparagine
Disulfide bond177↔189
Disulfide bond183↔198
Disulfide bond226↔239
Glycosylation229N-linked (GlcNAc...) asparagine
Disulfide bond233↔248
Glycosylation269N-linked (GlcNAc...) asparagine
Disulfide bond276↔286
Disulfide bond280↔295
Glycosylation283N-linked (GlcNAc...) asparagine
Glycosylation309N-linked (GlcNAc...) asparagine
Disulfide bond323↔336
Disulfide bond330↔345
Glycosylation333N-linked (GlcNAc...) asparagine
Glycosylation344N-linked (GlcNAc...) asparagine
Glycosylation363N-linked (GlcNAc...) asparagine
Glycosylation405N-linked (GlcNAc...) asparagine
Glycosylation417N-linked (GlcNAc...) asparagine
Glycosylation474N-linked (GlcNAc...) asparagine
Glycosylation499N-linked (GlcNAc...) asparagine
Disulfide bond596↔625
Disulfide bond613↔627
Glycosylation707N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, motif, region.

TypeIDPosition(s)Description
Domain32-69EGF-like 1
Domain81-119EGF-like 2
Domain133-172EGF-like 3; calcium-binding
Domain173-210EGF-like 4; calcium-binding
Domain222-260EGF-like 5; calcium-binding
Domain272-307EGF-like 6; calcium-binding
Domain319-354EGF-like 7; calcium-binding
Domain482-643GAIN-B
Motif507-509Cell attachment site
Region596-643GPS

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    932
  • Mass (Da)
    102,308
  • Last updated
    2004-11-23 v1
  • Checksum
    99C4B11C721EF8DA
MWGFWLLLFWGFSGTHRWGMTTLAILGQRLNGVNECQDTTTCPAYATCTDTTESYYCTCKQGFLPSNGQTNFQGPGVECQDVNECLRSDSPCGSNSVCTNIPGRARCSCLSGFSSSAGGSWILGSPGHFLCTDVDECLTIGICPKNSNCSNSVGSYSCTCQSGFVSNGSTCEDEDECVTRNACPEHATCHNTLGSYYCTCNEGLEFSGGGPMFQGLEESCEDVDECSRNSTLCGPSFICINTLGSYSCSCPAGFSLSTFQIPGHPADGNCTDIDECDDICPSNSSCTNTLGSYFCTCHPGFASSNGQLNFTDQEVTCEDIDECTQDPFRCGRNSSCTNVPGSYNCSCLPDFRMDPGGSQAHGNFTCKRIPFKCKEDLIPKSEQIEQCQAGQGRNLDYTSFCTFVNATFTILDNTCENKSAPVSLQSAATSVSLMLEQASTWFEFSREETSTLGTILLETVESTMLAALLTPSGNASQTIRTEYLEIESKVINEECNEENVSINLKARGDKMDVGCFIIKESESTGTPGVAFVSFAHMDSVLDERFFEDGQASWKLRMNSHVVGGTVTGERKEDFSKPIVYTLQHIQPKQKSERSICVSWNTDVEDGRWTPSGCETVEASETHTVCSCNRMTNLAIIMASGELTMEFSLYIISYVGTVISLVCLALAIATFLLFRAVQNHNTYLHLHLCVCLFLAKILFLTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVVVVIISATVHPWGYGMHNRCWLNTETGFIWSFLGPVCMIITINSALLAWTLWVLRQKLCSVNSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIFQIGPLASIMAYLFTTINSLQGAFIFLIHCLLNRQVRDEYRKLLTRKTDLSSHSQTSGILLSSMPSTSKTG

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5ZYF2A0A8I5ZYF2_RATAdgre1867
A0A8I5ZPM3A0A8I5ZPM3_RATAdgre1945

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY686632
EMBL· GenBank· DDBJ
AAU95564.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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