Q5Y4N8 · AGRE1_RAT
- ProteinAdhesion G protein-coupled receptor E2
- GeneAdgre1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids932 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Orphan receptor involved in cell adhesion and probably in cell-cell interactions involved specifically cells of the immune system. May play a role in regulatory T-cells (Treg) development.
Miscellaneous
Most adhesion GPCRs proteins undergo autoproteolysis at the GPS region of the GAIN-B domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS region.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cell periphery | |
Cellular Component | external side of plasma membrane | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | G protein-coupled receptor activity | |
Biological Process | adaptive immune response | |
Biological Process | adenylate cyclase-activating G protein-coupled receptor signaling pathway | |
Biological Process | cell surface receptor signaling pathway | |
Biological Process | cellular response to transforming growth factor beta stimulus | |
Biological Process | cellular response to tumor necrosis factor |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdhesion G protein-coupled receptor E2
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ5Y4N8
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 16-652 | Extracellular | ||||
Sequence: HRWGMTTLAILGQRLNGVNECQDTTTCPAYATCTDTTESYYCTCKQGFLPSNGQTNFQGPGVECQDVNECLRSDSPCGSNSVCTNIPGRARCSCLSGFSSSAGGSWILGSPGHFLCTDVDECLTIGICPKNSNCSNSVGSYSCTCQSGFVSNGSTCEDEDECVTRNACPEHATCHNTLGSYYCTCNEGLEFSGGGPMFQGLEESCEDVDECSRNSTLCGPSFICINTLGSYSCSCPAGFSLSTFQIPGHPADGNCTDIDECDDICPSNSSCTNTLGSYFCTCHPGFASSNGQLNFTDQEVTCEDIDECTQDPFRCGRNSSCTNVPGSYNCSCLPDFRMDPGGSQAHGNFTCKRIPFKCKEDLIPKSEQIEQCQAGQGRNLDYTSFCTFVNATFTILDNTCENKSAPVSLQSAATSVSLMLEQASTWFEFSREETSTLGTILLETVESTMLAALLTPSGNASQTIRTEYLEIESKVINEECNEENVSINLKARGDKMDVGCFIIKESESTGTPGVAFVSFAHMDSVLDERFFEDGQASWKLRMNSHVVGGTVTGERKEDFSKPIVYTLQHIQPKQKSERSICVSWNTDVEDGRWTPSGCETVEASETHTVCSCNRMTNLAIIMASGELTMEFSLYIIS | ||||||
Transmembrane | 653-673 | Helical; Name=1 | ||||
Sequence: YVGTVISLVCLALAIATFLLF | ||||||
Topological domain | 674-681 | Cytoplasmic | ||||
Sequence: RAVQNHNT | ||||||
Transmembrane | 682-702 | Helical; Name=2 | ||||
Sequence: YLHLHLCVCLFLAKILFLTGI | ||||||
Topological domain | 703-719 | Extracellular | ||||
Sequence: DKTDNQTACAIIAGFLH | ||||||
Transmembrane | 720-740 | Helical; Name=3 | ||||
Sequence: YLFLACFFWMLVEAVMLFLMV | ||||||
Topological domain | 741-756 | Cytoplasmic | ||||
Sequence: RNLKVVNYFSSRNIKM | ||||||
Transmembrane | 757-777 | Helical; Name=4 | ||||
Sequence: LHLCAFGYGLPVVVVIISATV | ||||||
Topological domain | 778-795 | Extracellular | ||||
Sequence: HPWGYGMHNRCWLNTETG | ||||||
Transmembrane | 796-816 | Helical; Name=5 | ||||
Sequence: FIWSFLGPVCMIITINSALLA | ||||||
Topological domain | 817-849 | Cytoplasmic | ||||
Sequence: WTLWVLRQKLCSVNSEVSKLKDTRLLTFKAIAQ | ||||||
Transmembrane | 850-870 | Helical; Name=6 | ||||
Sequence: IFILGCSWVLGIFQIGPLASI | ||||||
Topological domain | 871-872 | Extracellular | ||||
Sequence: MA | ||||||
Transmembrane | 873-893 | Helical; Name=7 | ||||
Sequence: YLFTTINSLQGAFIFLIHCLL | ||||||
Topological domain | 894-932 | Cytoplasmic | ||||
Sequence: NRQVRDEYRKLLTRKTDLSSHSQTSGILLSSMPSTSKTG |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MWGFWLLLFWGFSGT | ||||||
Chain | PRO_0000250959 | 16-932 | Adhesion G protein-coupled receptor E2 | |||
Sequence: HRWGMTTLAILGQRLNGVNECQDTTTCPAYATCTDTTESYYCTCKQGFLPSNGQTNFQGPGVECQDVNECLRSDSPCGSNSVCTNIPGRARCSCLSGFSSSAGGSWILGSPGHFLCTDVDECLTIGICPKNSNCSNSVGSYSCTCQSGFVSNGSTCEDEDECVTRNACPEHATCHNTLGSYYCTCNEGLEFSGGGPMFQGLEESCEDVDECSRNSTLCGPSFICINTLGSYSCSCPAGFSLSTFQIPGHPADGNCTDIDECDDICPSNSSCTNTLGSYFCTCHPGFASSNGQLNFTDQEVTCEDIDECTQDPFRCGRNSSCTNVPGSYNCSCLPDFRMDPGGSQAHGNFTCKRIPFKCKEDLIPKSEQIEQCQAGQGRNLDYTSFCTFVNATFTILDNTCENKSAPVSLQSAATSVSLMLEQASTWFEFSREETSTLGTILLETVESTMLAALLTPSGNASQTIRTEYLEIESKVINEECNEENVSINLKARGDKMDVGCFIIKESESTGTPGVAFVSFAHMDSVLDERFFEDGQASWKLRMNSHVVGGTVTGERKEDFSKPIVYTLQHIQPKQKSERSICVSWNTDVEDGRWTPSGCETVEASETHTVCSCNRMTNLAIIMASGELTMEFSLYIISYVGTVISLVCLALAIATFLLFRAVQNHNTYLHLHLCVCLFLAKILFLTGIDKTDNQTACAIIAGFLHYLFLACFFWMLVEAVMLFLMVRNLKVVNYFSSRNIKMLHLCAFGYGLPVVVVIISATVHPWGYGMHNRCWLNTETGFIWSFLGPVCMIITINSALLAWTLWVLRQKLCSVNSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIFQIGPLASIMAYLFTTINSLQGAFIFLIHCLLNRQVRDEYRKLLTRKTDLSSHSQTSGILLSSMPSTSKTG | ||||||
Disulfide bond | 36↔48 | |||||
Sequence: CQDTTTCPAYATC | ||||||
Disulfide bond | 42↔57 | |||||
Sequence: CPAYATCTDTTESYYC | ||||||
Disulfide bond | 85↔98 | |||||
Sequence: CLRSDSPCGSNSVC | ||||||
Disulfide bond | 92↔107 | |||||
Sequence: CGSNSVCTNIPGRARC | ||||||
Disulfide bond | 137↔149 | |||||
Sequence: CLTIGICPKNSNC | ||||||
Disulfide bond | 143↔158 | |||||
Sequence: CPKNSNCSNSVGSYSC | ||||||
Glycosylation | 148 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 160↔171 | |||||
Sequence: CQSGFVSNGSTC | ||||||
Glycosylation | 167 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 177↔189 | |||||
Sequence: CVTRNACPEHATC | ||||||
Disulfide bond | 183↔198 | |||||
Sequence: CPEHATCHNTLGSYYC | ||||||
Disulfide bond | 226↔239 | |||||
Sequence: CSRNSTLCGPSFIC | ||||||
Glycosylation | 229 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 233↔248 | |||||
Sequence: CGPSFICINTLGSYSC | ||||||
Glycosylation | 269 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 276↔286 | |||||
Sequence: CDDICPSNSSC | ||||||
Disulfide bond | 280↔295 | |||||
Sequence: CPSNSSCTNTLGSYFC | ||||||
Glycosylation | 283 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 309 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 323↔336 | |||||
Sequence: CTQDPFRCGRNSSC | ||||||
Disulfide bond | 330↔345 | |||||
Sequence: CGRNSSCTNVPGSYNC | ||||||
Glycosylation | 333 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 344 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 363 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 405 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 417 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 474 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 499 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 596↔625 | |||||
Sequence: CVSWNTDVEDGRWTPSGCETVEASETHTVC | ||||||
Disulfide bond | 613↔627 | |||||
Sequence: CETVEASETHTVCSC | ||||||
Glycosylation | 707 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, motif, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-69 | EGF-like 1 | ||||
Sequence: GVNECQDTTTCPAYATCTDTTESYYCTCKQGFLPSNGQ | ||||||
Domain | 81-119 | EGF-like 2 | ||||
Sequence: DVNECLRSDSPCGSNSVCTNIPGRARCSCLSGFSSSAGG | ||||||
Domain | 133-172 | EGF-like 3; calcium-binding | ||||
Sequence: DVDECLTIGICPKNSNCSNSVGSYSCTCQSGFVSNGSTCE | ||||||
Domain | 173-210 | EGF-like 4; calcium-binding | ||||
Sequence: DEDECVTRNACPEHATCHNTLGSYYCTCNEGLEFSGGG | ||||||
Domain | 222-260 | EGF-like 5; calcium-binding | ||||
Sequence: DVDECSRNSTLCGPSFICINTLGSYSCSCPAGFSLSTFQ | ||||||
Domain | 272-307 | EGF-like 6; calcium-binding | ||||
Sequence: DIDECDDICPSNSSCTNTLGSYFCTCHPGFASSNGQ | ||||||
Domain | 319-354 | EGF-like 7; calcium-binding | ||||
Sequence: DIDECTQDPFRCGRNSSCTNVPGSYNCSCLPDFRMD | ||||||
Domain | 482-643 | GAIN-B | ||||
Sequence: EYLEIESKVINEECNEENVSINLKARGDKMDVGCFIIKESESTGTPGVAFVSFAHMDSVLDERFFEDGQASWKLRMNSHVVGGTVTGERKEDFSKPIVYTLQHIQPKQKSERSICVSWNTDVEDGRWTPSGCETVEASETHTVCSCNRMTNLAIIMASGELT | ||||||
Motif | 507-509 | Cell attachment site | ||||
Sequence: RGD | ||||||
Region | 596-643 | GPS | ||||
Sequence: CVSWNTDVEDGRWTPSGCETVEASETHTVCSCNRMTNLAIIMASGELT |
Sequence similarities
Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Protein family/group databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length932
- Mass (Da)102,308
- Last updated2004-11-23 v1
- Checksum99C4B11C721EF8DA
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I5ZYF2 | A0A8I5ZYF2_RAT | Adgre1 | 867 | ||
A0A8I5ZPM3 | A0A8I5ZPM3_RAT | Adgre1 | 945 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY686632 EMBL· GenBank· DDBJ | AAU95564.1 EMBL· GenBank· DDBJ | mRNA |