Q5T9L3 · WLS_HUMAN

  • Protein
    Protein wntless homolog
  • Gene
    WLS
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (PubMed:34587386).
Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentcytosol
Cellular Componentearly endosome
Cellular Componentearly endosome membrane
Cellular Componentendocytic vesicle membrane
Cellular Componentendomembrane system
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentextracellular exosome
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Cellular Componentorganelle membrane
Cellular Componentplasma membrane
Cellular Componenttrans-Golgi network
Molecular Functionidentical protein binding
Molecular FunctionWnt-protein binding
Biological Processanterior/posterior axis specification
Biological Processcementum mineralization
Biological Processexocrine pancreas development
Biological Processhindbrain development
Biological Processintracellular protein transport
Biological Processmesoderm formation
Biological Processmidbrain development
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of canonical Wnt signaling pathway
Biological Processpositive regulation of Wnt protein secretion
Biological Processpositive regulation of Wnt signaling pathway
Biological ProcessWnt protein secretion
Biological ProcessWnt signaling pathway

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein wntless homolog
  • Alternative names
    • Integral membrane protein GPR177
    • Protein evenness interrupted homolog (EVI)
    • Putative NF-kappa-B-activating protein 373

Gene names

    • Name
      WLS
    • Synonyms
      C1orf139, GPR177
    • ORF names
      UNQ85/PRO18667

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q5T9L3
  • Secondary accessions
    • B2RNT2
    • Q5JRS7
    • Q7Z2Z9
    • Q8NC43

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Multi-pass membrane protein
Cytoplasmic vesicle membrane
; Multi-pass membrane protein
Cell membrane
; Multi-pass membrane protein
Endoplasmic reticulum membrane
; Multi-pass membrane protein
Golgi apparatus membrane
; Multi-pass membrane protein
Early endosome membrane
; Multi-pass membrane protein
Note: Co-localizes with the adaptin AP2A2 at distinct punctae.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-15Cytoplasmic
Transmembrane16-36Helical; Name=1
Topological domain37-232Lumenal
Transmembrane233-253Helical; Name=2
Topological domain254-268Cytoplasmic
Transmembrane269-289Helical; Name=3
Topological domain290-303Lumenal
Transmembrane304-324Helical; Name=4
Topological domain325-331Cytoplasmic
Transmembrane332-352Helical; Name=5
Topological domain353-380Lumenal
Transmembrane381-401Helical; Name=6
Topological domain402-431Cytoplasmic
Transmembrane432-452Helical; Name=7
Topological domain453-471Lumenal
Transmembrane472-492Helical; Name=8
Topological domain493-541Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

Zaki syndrome (ZKS)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    An autosomal recessive disorder characterized by developmental delay, progressive microcephaly, and short stature, as well as dysmorphic features including sparse scalp hair, cupped ears, wide nose and mouth, short philtrum, and high-arched palate. Other variable features have been observed, including ocular, skeletal, cardiac, and renal anomalies.
  • See also
    MIM:619648
Natural variants in ZKS
Variant IDPosition(s)ChangeDescription
VAR_086565392Y>Cin ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs2100452147
VAR_086566478Y>Cin ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs985347096
VAR_086567531I>Tin ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs2100377758
VAR_086568536R>Cin ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs773311381

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_086565392in ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs2100452147
Natural variantVAR_029991465in dbSNP:rs983034
Natural variantVAR_086566478in ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs985347096
Natural variantVAR_086567531in ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs2100377758
Natural variantVAR_086568536in ZKS; results in decreased secretion of WNT3A and WNT5A; decreased activation of WNT signaling; dbSNP:rs773311381

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 677 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002717771-541Protein wntless homolog

Post-translational modification

N-glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region101-232Interaction with Wnt proteins

Sequence similarities

Belongs to the wntless family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q5T9L3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    541
  • Mass (Da)
    62,253
  • Last updated
    2007-01-09 v2
  • Checksum
    0DAFDF51BBA0C288
MAGAIIENMSTKKLCIVGGILLVFQIIAFLVGGLIAPGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIRENAEVSMDVSLAYRDDAFAEWTEMAHERVPRKLKCTFTSPKTPEHEGRYYECDVLPFMEIGSVAHKFYLLNIRLPVNEKKKINVGIGEIKDIRLVGIHQNGGFTKVWFAMKTFLTPSIFIIMVWYWRRITMMSRPPVLLEKVIFALGISMTFINIPVEWFSIGFDWTWMLLFGDIRQGIFYAMLLSFWIIFCGEHMMDQHERNHIAGYWKQVGPIAVGSFCLFIFDMCERGVQLTNPFYSIWTTDIGTELAMAFIIVAGICLCLYFLFLCFMVFQVFRNISGKQSSLPAMSKVRRLHYEGLIFRFKFLMLITLACAAMTVIFFIVSQVTEGHWKWGGVTVQVNSAFFTGIYGMWNLYVFALMFLYAPSHKNYGEDQSNGDLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE

Q5T9L3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 36-37: Missing
    • 507-541: DLGVHSGEELQLTTTITHVDGPTEIYKLTRKEAQE → MQLPCKSREDCALFVSELYQELFSASKYSFINDNAASGI

Q5T9L3-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 36-127: APGPTTAVSYMSVKCVDARKNHHKTKWFVPWGPNHCDKIRDIEEAIPREIEANDIVFSVHIPLPHMEMSPWFQFMLFILQLDIAFKLNNQIR → G

Computationally mapped potential isoform sequences

There are 7 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YCG9H0YCG9_HUMANWLS200
E9PQK1E9PQK1_HUMANWLS152
E9PM23E9PM23_HUMANWLS38
E9PM62E9PM62_HUMANWLS222
E9PJW4E9PJW4_HUMANWLS134
E9PKJ0E9PKJ0_HUMANWLS122
Q7Z430Q7Z430_HUMANWLS127

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_02234636-37in isoform 2
Alternative sequenceVSP_04614336-127in isoform 3
Sequence conflict136in Ref. 4; CAD98094
Alternative sequenceVSP_022347507-541in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DQ323735
EMBL· GenBank· DDBJ
ABD58927.1
EMBL· GenBank· DDBJ
mRNA
AY359035
EMBL· GenBank· DDBJ
AAQ89394.1
EMBL· GenBank· DDBJ
mRNA
AK074984
EMBL· GenBank· DDBJ
BAC11333.1
EMBL· GenBank· DDBJ
mRNA
BX538320
EMBL· GenBank· DDBJ
CAD98094.1
EMBL· GenBank· DDBJ
mRNA
BX648748
EMBL· GenBank· DDBJ
-mRNA No translation available.
AL513284
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL157407
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471059
EMBL· GenBank· DDBJ
EAX06480.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471059
EMBL· GenBank· DDBJ
EAX06481.1
EMBL· GenBank· DDBJ
Genomic DNA
BC110826
EMBL· GenBank· DDBJ
AAI10827.1
EMBL· GenBank· DDBJ
mRNA
BC137109
EMBL· GenBank· DDBJ
AAI37110.1
EMBL· GenBank· DDBJ
mRNA
BC137113
EMBL· GenBank· DDBJ
AAI37114.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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