Q5SIL0 · SDRP_THET8

Function

function

Activates transcription. The consensus DNA-binding site of this transcriptional regulator is 5'-WWGTGAN(5-7)ACACWW-3' in which W is A or T and N is G, A, T or C. Regulated genes include those encoding proteins involved in nutrient and energy supply, redox control and polyadenylation of mRNA (PubMed:18699868).
Also regulates genes involved in oxidative stress response such as genes encoding manganese superoxide dismutase and catalase, and genes encoding a protein involved in nucleotide excision repair of damaged DNA and putative proteins involved in redox control, protein degradation and transcriptional regulation (PubMed:21054499).

Features

Showing features for dna binding.

120220406080100120140160180200
TypeIDPosition(s)Description
DNA binding149-168H-T-H motif

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity
Molecular Functionprotein homodimerization activity
Biological Processpositive regulation of DNA-templated transcription
Biological Processresponse to oxidative stress

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulator SdrP
  • Alternative names
    • Cyclic AMP receptor protein/Fumarate and nitrate reduction regulator superfamily protein SdrP
      (CRP/FNR superfamily protein SdrP
      )
    • Oxidative stress-responsive transcriptional activator SdrP
    • Stationary phase-dependent regulatory protein
      (SdrP
      )

Gene names

    • Ordered locus names
      TTHA1359

Organism names

Accessions

  • Primary accession
    Q5SIL0

Proteomes

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Viable, but has growth defects, particularly when grown in a synthetic medium. Increased sensitivity to disulfide stress. Decreased expression of TTHA0986, TTHA0770, TTHA0337, TTHA1028, TTHA0654, TTHA0655, TTHA0769, TTHA0425, TTHA0634, TTHA0635, TTHA0636, TTHA0637, TTHA0638, TTHA0570, TTHA0030, TTHA0460, TTHB243, TTHA1128, TTHA0035, TTHA0520 and TTHA1803 genes.

PTM/Processing

Features

Showing features for initiator methionine, chain.

Type
IDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00004362592-202Transcriptional regulator SdrP

Expression

Induction

Increased expression during the stationary phase when grown at 70 degrees Celsius (PubMed:18699868).
Increased expression during the logarithmic growth phase in oxidative stress and upon treatment with diamide. Increased expression by heavy metal ion, antibiotic, high salt and organic solvent stresses (PubMed:21054499).

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain117-189HTH crp-type

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    202
  • Mass (Da)
    22,317
  • Last updated
    2004-12-21 v1
  • MD5 Checksum
    D3C6F3A19BF26134E8AC20A20935F7B8
MTQVRETVSFKAGDVILYPGVPGPRDRAYRVLEGLVRLEAVDEEGNALTLRLVRPGGFFGEEALFGQERIYFAEAATDVRLEPLPENPDPELLKDLAQHLSQGLAEAYRRIERLATQRLKNRMAAALLELSETPLAHEEEGKVVLKATHDELAAAVGSVRETVTKVIGELAREGYIRSGYGKIQLLDLKGLKELAESRGQGR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008226
EMBL· GenBank· DDBJ
BAD71182.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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