Q49W03 · ENO_STAS1

Function

function

Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds a second Mg2+ ion via substrate during catalysis.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site165(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Active site207Proton donor
Binding site244Mg2+ (UniProtKB | ChEBI)
Binding site291Mg2+ (UniProtKB | ChEBI)
Binding site318Mg2+ (UniProtKB | ChEBI)
Active site343Proton acceptor
Binding site343(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Binding site372(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Binding site373(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Binding site394(2R)-2-phosphoglycerate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componentphosphopyruvate hydratase complex
Molecular Functionmagnesium ion binding
Molecular Functionphosphopyruvate hydratase activity
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enolase
  • EC number
  • Alternative names
    • 2-phospho-D-glycerate hydro-lyase
    • 2-phosphoglycerate dehydratase

Gene names

    • Name
      eno
    • Ordered locus names
      SSP1912

Organism names

Accessions

  • Primary accession
    Q49W03

Proteomes

Subcellular Location

Cytoplasm
Secreted
Cell surface
Note: Fractions of enolase are present in both the cytoplasm and on the cell surface.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002671141-434Enolase

Structure

Family & Domains

Sequence similarities

Belongs to the enolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    434
  • Mass (Da)
    47,075
  • Last updated
    2005-09-13 v1
  • Checksum
    45F268DEA24FFCBE
MPIITDVYAREVLDSRGNPTVEVEVLTESGAFGRALVPSGASTGEHEAVELRDGDKSRYLGKGVTKAVDNVNEIIAPELIEGEFSVLEQVSIDKMMIQLDGTENKGKLGANAILGVSIAVARAAADLLGQPLYKYLGGFNGKQLPVPMMNIVNGGSHSDAPIAFQEFMVLPVGAESFKESLRWGAEIFHNLKSILKNRGLETAVGDEGGFAPKFEGTEDAVETILEAIKAVGLEPGKDVFLGFDCASSEFFEDGVYNYAKFEGENGAKRSAEEQVDYLEELVNKYPIITIEDGMDENDWDGWKVLTDRIGDKVQLVGDDLFVTNTVKLSEGIEKGIGNSILIKVNQIGTLTETFDAIEMAQKAGYTAVVSHRSGETEDTTISDIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDELYETGKFDGLKSFYNLSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP008934
EMBL· GenBank· DDBJ
BAE19057.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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