Q2FWD3 · Q2FWD3_STAA8

Function

function

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit. One is catalytic and the other provides a structural contribution.

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Features

Showing features for active site, binding site.

TypeIDPosition(s)Description
Active site85Proton donor
Binding site86Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site107Zn2+ 2 (UniProtKB | ChEBI)
Binding site137Zn2+ 2 (UniProtKB | ChEBI)
Binding site181Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site182dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site209Zn2+ 1 (UniProtKB | ChEBI); catalytic
Binding site210-212dihydroxyacetone phosphate (UniProtKB | ChEBI)
Binding site231-234dihydroxyacetone phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionfructose-bisphosphate aldolase activity
Molecular Functionzinc ion binding
Biological Processfructose 1,6-bisphosphate metabolic process
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fructose-bisphosphate aldolase
  • EC number
  • Alternative names
    • Fructose-1,6-bisphosphate aldolase

Gene names

    • Ordered locus names
      SAOUHSC_02366

Organism names

Accessions

  • Primary accession
    Q2FWD3

Proteomes

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the class II fructose-bisphosphate aldolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    286
  • Mass (Da)
    30,836
  • Last updated
    2006-03-21 v1
  • Checksum
    7A5FD0EBD48283D9
MPLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTIVKMVEGLMHDLNITIPVAIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKECQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000253
EMBL· GenBank· DDBJ
ABD31397.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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