Q28E01 · S20A2_XENTR
- ProteinSodium-dependent phosphate transporter 2
- Geneslc20a2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids653 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion.
Catalytic activity
- 2 Na+(out) + phosphate(out) = 2 Na+(in) + phosphate(in)
2 Na+ (out)CHEBI:29101+ phosphate (out)CHEBI:43474= 2 Na+ (in)CHEBI:29101+ phosphate (in)CHEBI:43474
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | brush border membrane | |
Cellular Component | plasma membrane | |
Molecular Function | sodium:phosphate symporter activity | |
Biological Process | phosphate ion transport |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSodium-dependent phosphate transporter 2
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Silurana
Accessions
- Primary accessionQ28E01
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Apical cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1 | Extracellular | ||||
Sequence: M | ||||||
Transmembrane | 2-22 | Helical | ||||
Sequence: VLVEYLWMVIVGFIIAFILAF | ||||||
Topological domain | 23-46 | Cytoplasmic | ||||
Sequence: SVGANDVANSFGTAVGSGVVTLRQ | ||||||
Transmembrane | 47-67 | Helical | ||||
Sequence: ACILASIFETTGSVLLGAKVG | ||||||
Topological domain | 68-86 | Extracellular | ||||
Sequence: ETIRKGIIDVNLYNNTVDL | ||||||
Transmembrane | 87-107 | Helical | ||||
Sequence: LMAGEVSAMVGSAVWQLIASF | ||||||
Topological domain | 108-109 | Cytoplasmic | ||||
Sequence: LR | ||||||
Transmembrane | 110-130 | Helical | ||||
Sequence: LPISGTHCIVGATIGFSLVAI | ||||||
Topological domain | 131-142 | Extracellular | ||||
Sequence: GTHGVQWMQLVK | ||||||
Transmembrane | 143-163 | Helical | ||||
Sequence: IVASWFISPLLSGLMSGALFL | ||||||
Topological domain | 164-187 | Cytoplasmic | ||||
Sequence: MIKFFILKKEDPVPNGLKALPVFY | ||||||
Transmembrane | 188-208 | Helical | ||||
Sequence: AATIGINVFSILYTGAPLLGL | ||||||
Topological domain | 209-217 | Extracellular | ||||
Sequence: ESFPVWATA | ||||||
Transmembrane | 218-238 | Helical | ||||
Sequence: LLSIGIAIIFALIVWFFVCPW | ||||||
Topological domain | 239-483 | Cytoplasmic | ||||
Sequence: MKKKIASRLKKEGALSRISEESLDKIQDEETSVFKELPGAKGNDESALPLTSSSTDAAVASDSVSNGNTRVPYGRAASMTNGSIRSPISNGTFNFDGHTVKSDVHVYHTVHKDSGLYKDLLHNIHLDRVKTDRPAPENNYRVLRRNNSYTCYTAAICGVPVHSTFKSSDVAMPEDSEKLVGDTVSYSKKRVRYDSYSSYCNAVAEAEIEAEEGGVEMKLATDLADPNPPQDDSLEEDKEEKDKSE | ||||||
Transmembrane | 484-504 | Helical | ||||
Sequence: VHLLFHFLQILTACFGSFAHG | ||||||
Topological domain | 505-532 | Extracellular | ||||
Sequence: GNDVSNAIGPLVALWLIYEQGGVMQEAS | ||||||
Transmembrane | 533-553 | Helical | ||||
Sequence: TPVWLLLYGGVGICAGLWVWG | ||||||
Topological domain | 554-572 | Cytoplasmic | ||||
Sequence: RRVIQTMGKDLTPITPSSG | ||||||
Transmembrane | 573-587 | Helical | ||||
Sequence: FTIELASAFTVVVAS | ||||||
Topological domain | 588-594 | Extracellular | ||||
Sequence: NIGLPIS | ||||||
Transmembrane | 595-610 | Helical | ||||
Sequence: TTHCKVGSVVAVGWIR | ||||||
Topological domain | 611-622 | Cytoplasmic | ||||
Sequence: SRKAVDWRLFRN | ||||||
Transmembrane | 623-643 | Helical | ||||
Sequence: IFLAWFVTVPVAGLFSAGVMA | ||||||
Topological domain | 644-653 | Extracellular | ||||
Sequence: ILQYGILPYV |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000341272 | 1-653 | Sodium-dependent phosphate transporter 2 | |||
Sequence: MVLVEYLWMVIVGFIIAFILAFSVGANDVANSFGTAVGSGVVTLRQACILASIFETTGSVLLGAKVGETIRKGIIDVNLYNNTVDLLMAGEVSAMVGSAVWQLIASFLRLPISGTHCIVGATIGFSLVAIGTHGVQWMQLVKIVASWFISPLLSGLMSGALFLMIKFFILKKEDPVPNGLKALPVFYAATIGINVFSILYTGAPLLGLESFPVWATALLSIGIAIIFALIVWFFVCPWMKKKIASRLKKEGALSRISEESLDKIQDEETSVFKELPGAKGNDESALPLTSSSTDAAVASDSVSNGNTRVPYGRAASMTNGSIRSPISNGTFNFDGHTVKSDVHVYHTVHKDSGLYKDLLHNIHLDRVKTDRPAPENNYRVLRRNNSYTCYTAAICGVPVHSTFKSSDVAMPEDSEKLVGDTVSYSKKRVRYDSYSSYCNAVAEAEIEAEEGGVEMKLATDLADPNPPQDDSLEEDKEEKDKSEVHLLFHFLQILTACFGSFAHGGNDVSNAIGPLVALWLIYEQGGVMQEASTPVWLLLYGGVGICAGLWVWGRRVIQTMGKDLTPITPSSGFTIELASAFTVVVASNIGLPISTTHCKVGSVVAVGWIRSRKAVDWRLFRNIFLAWFVTVPVAGLFSAGVMAILQYGILPYV | ||||||
Glycosylation | 81 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length653
- Mass (Da)70,621
- Last updated2006-04-04 v1
- ChecksumC16BB5C2A5A4BB79
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8R9M0 | A0A6I8R9M0_XENTR | slc20a2 | 600 | ||
A0A8J1JDV6 | A0A8J1JDV6_XENTR | slc20a2 | 653 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CR848513 EMBL· GenBank· DDBJ | CAJ82318.1 EMBL· GenBank· DDBJ | mRNA |