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UniProtKB - Q14160 (SCRIB_HUMAN)

Entry version 212 (07 Apr 2021)
Sequence version 4 (13 Oct 2009)
Previous versions | rss
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Protein

Protein scribble homolog

Gene

SCRIB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:15182672, PubMed:16344308, PubMed:19041750, PubMed:18716323, PubMed:18641685, PubMed:16965391, PubMed:27380321). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:16344308, PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:16965391, PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323, PubMed:18641685). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:15182672). Functions as an activator of Rac GTPase activity.By similarity7 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host interferon signaling pathway by virus, Inhibition of host STAT1 by virus, Inhibition of host STAT2 by virus, Viral immunoevasion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q14160

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-4608870, Asymmetric localization of PCP proteins

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q14160

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q14160, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein scribble homolog
Short name:
Scribble
Short name:
hScrib
Alternative name(s):
Protein LAP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCRIB
Synonyms:CRIB1, KIAA0147, LAP4, SCRB1, VARTUL
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:30377, SCRIB

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		607733, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q14160

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000180900.16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neural tube defects (NTD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionCongenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_067219454P → S in NTD; protein interactions not affected by the mutation; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1302482009Ensembl.1
Natural variantiVAR_0672201535R → Q in NTD; protein interactions not affected by the mutation; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs782428100Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi4C → S: Loss of palmitoylation. Loss of palmitoylation, localization to cell-cell junctions and function in epithelial cell polarization and signaling pathways regulation; when associated with S-10. 1 Publication1
Mutagenesisi10C → S: Loss of palmitoylation. Loss of palmitoylation, localization to cell-cell junctions and function in epithelial cell polarization and signaling pathways regulation; when associated with S-4. 1 Publication1
Mutagenesisi22C → S: No effect on palmitoylation. 1 Publication1
Mutagenesisi305P → L: Decreased palmitoylation. Loss of targeting to cell-cell junctions. Targeted to the cytoplasm. Alters interaction with TJP2. Loss of pro-apoptotic function. Loss of function in epithelial cell polarization and signaling pathways regulation. 3 Publications1
Mutagenesisi738 – 739LG → AE: Alters interaction with LPP. 1 Publication2
Mutagenesisi738L → R: Loss of anti-proliferative activity. 1
Mutagenesisi872 – 873LG → AE: Alters interaction with LPP. 1 Publication2
Mutagenesisi1014 – 1015LG → AE: Loss of interaction with LPP and TRIP6. 1 Publication2
Mutagenesisi1111 – 1112LG → AE: Alters interaction with LPP. 1 Publication2

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		23513

MalaCards human disease database

More...MalaCardsi		SCRIB
MIMi182940, phenotype

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134936275

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q14160, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SCRIB

Domain mapping of disease mutations (DMDM)

More...DMDMi		261260101

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001883031 – 1630Protein scribble homologAdd BLAST1630

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei37PhosphoserineCombined sources1
Modified residuei378PhosphothreonineCombined sources1
Modified residuei475PhosphothreonineCombined sources1
Modified residuei504PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1
Modified residuei689PhosphothreonineCombined sources1
Modified residuei708PhosphoserineCombined sources1
Modified residuei764PhosphoserineCombined sources1
Modified residuei826PhosphothreonineCombined sources1
Modified residuei835PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1
Modified residuei875PhosphoserineCombined sources1
Modified residuei939PhosphoserineCombined sources1
Modified residuei1140PhosphoserineCombined sources1
Modified residuei1220PhosphoserineCombined sources1
Modified residuei1223PhosphoserineCombined sources1
Modified residuei1226PhosphoserineCombined sources1
Modified residuei1232PhosphoserineCombined sources1
Modified residuei1276PhosphoserineCombined sources1
Modified residuei1279PhosphoserineCombined sources1
Modified residuei1295PhosphoserineCombined sources1
Modified residuei1298PhosphoserineCombined sources1
Modified residuei1306PhosphoserineCombined sources1
Modified residuei1309PhosphoserineCombined sources1
Modified residuei1342PhosphothreonineCombined sources1
Modified residuei1348PhosphoserineCombined sources1
Modified residuei1378PhosphoserineCombined sources1
Modified residuei1437PhosphoserineCombined sources1
Modified residuei1445PhosphoserineCombined sources1
Modified residuei1448PhosphoserineCombined sources1
Modified residuei1475PhosphoserineCombined sources1
Modified residuei1486PhosphoserineCombined sources1
Modified residuei1508PhosphoserineCombined sources1
Modified residuei1541PhosphoserineCombined sources1
Modified residuei1545PhosphothreonineCombined sources1
Modified residuei1547PhosphoserineCombined sources1
Modified residuei1561PhosphoserineCombined sources1
Modified residuei1566PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; targeted for UBE3A-dependent multiubiquitination in the presence of high-risk HPV E6 proteins and degraded.1 Publication
Palmitoylated (PubMed:27380321). Could be depalmitoylated by LYPLA1 and/or LYPLA2 (PubMed:27380321). Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation (PubMed:27380321).1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q14160

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q14160

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q14160

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q14160

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q14160

PeptideAtlas

More...PeptideAtlasi		Q14160

PRoteomics IDEntifications database

More...PRIDEi		Q14160

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		59873 [Q14160-1]
59874 [Q14160-2]
59875 [Q14160-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q14160, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q14160

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q14160

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q14160

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney, skeletal muscles, liver, lung, breast, intestine, placenta and skin mainly in epithelial cells (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000180900, Expressed in lower esophagus mucosa and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q14160, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q14160, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000180900, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with UBE3A (PubMed:11027293).

Interacts with PAK1 and PAK2 (PubMed:18716323).

Interacts (via PDZ domains) with VANGL2 (By similarity).

Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (PubMed:15649318, PubMed:16137684).

Interacts (via PDZ domains) with TJP2 (PubMed:15975580).

Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247).

Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (PubMed:15775968).

Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672).

Interacts with CTNNB1 (By similarity).

Interacts with MAPK12 (By similarity).

Interacts (via PDZ domains 1 and 3) with MCC (PubMed:19555689, PubMed:22480440).

Interacts with DLG5 (PubMed:28169360).

Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (PubMed:28169360).

Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (By similarity).

By similarity11 Publications

(Microbial infection) Interacts (via fourth PDZ domain) with tick-borne encephalitis virus RNA-directed RNA polymerase NS5; this interaction targets viral NS5 to the cell membrane periphery and nucleus and prevents STAT1 phosphorylation, and thus, the activation of the JAK-STAT signaling pathway (PubMed:18042258).

Interacts with HPV E6 (PubMed:11027293).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q14160
With#Exp.IntAct
ADAM22 [Q9P0K1]3EBI-357345,EBI-1567236
ADRA1D [P25100]19EBI-357345,EBI-489993
APC [P25054]5EBI-357345,EBI-727707
ARHGEF16 [Q5VV41]2EBI-357345,EBI-1057448
ARHGEF7 [Q14155]11EBI-357345,EBI-717515
ATP2B1 [P20020]2EBI-357345,EBI-5279998
ATP2B2 [Q01814]2EBI-357345,EBI-1174243
CRHR1 [P34998]3EBI-357345,EBI-3870393
CTNND2 [Q9UQB3]2EBI-357345,EBI-7266482
CYSLTR2 [Q9NS75]3EBI-357345,EBI-3843579
DNM1L [O00429]2EBI-357345,EBI-724571
FAM163B [P0C2L3]3EBI-357345,EBI-11793223
FASTKD5 [Q7L8L6]2EBI-357345,EBI-747570
FRMPD4 [Q14CM0]2EBI-357345,EBI-311279
GUCY1A2 [P33402]6EBI-357345,EBI-6911715
KCNA5 [P22460]2EBI-357345,EBI-6426121
KCNJ12 [Q14500]2EBI-357345,EBI-11794596
KCNJ4 [P48050]2EBI-357345,EBI-706117
MAPK12 [P53778]6EBI-357345,EBI-602406
MAPK3 [P27361]2EBI-357345,EBI-73995
MCC [P23508]14EBI-357345,EBI-307531
NET1 [Q7Z628]2EBI-357345,EBI-2511306
NXPE2 [Q96DL1]2EBI-357345,EBI-11791121
PHLPP1 [O60346]2EBI-357345,EBI-2511516
PKP4 [Q99569]4EBI-357345,EBI-726447
RALBP1 [Q15311]2EBI-357345,EBI-749285
RPS6KA1 [Q15418]3EBI-357345,EBI-963034
RPS6KA2 [Q15349]9EBI-357345,EBI-1384149
SLC15A5 [A6NIM6]2EBI-357345,EBI-11792220
SLC6A12 [P48065]2EBI-357345,EBI-3843589
TANC1 [Q9C0D5]4EBI-357345,EBI-11023211
TSHR [P16473]3EBI-357345,EBI-13939599
VEPH1 [Q14D04]2EBI-357345,EBI-1043669
WTIP [A6NIX2]2EBI-357345,EBI-20730502
WWTR1 [Q9GZV5]3EBI-357345,EBI-747743
YAP1 [P46937]2EBI-357345,EBI-1044059
B7Z2Y13EBI-357345,EBI-11791049
E6 [P03126] from Human papillomavirus type 16.8EBI-357345,EBI-1177242
E6 [P06427] from Human papillomavirus 33.3EBI-357345,EBI-11737184
E6 [P06463] from Human papillomavirus type 18.4EBI-357345,EBI-1186926
E6 [P24835] from Human papillomavirus 39.2EBI-357345,EBI-11793707
Fat1 [Q9QXA3] from Mus musculus.5EBI-357345,EBI-6980218
tax [P0C213] from Human T-cell leukemia virus 1 (isolate Zaire EL subtype B).2EBI-357345,EBI-11793850
tax [P0C222] from Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C).2EBI-357345,EBI-11794384

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117060, 101 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6168, Scribble cell polarity complex, DLG1-LLGL2-SCRIB variant
CPX-6184, Scribble cell polarity complex, DLG2-LLGL2-SCRIB variant
CPX-6185, Scribble cell polarity complex, DLG3-LLGL2-SCRIB variant
CPX-6186, Scribble cell polarity complex, DLG4-LLGL2-SCRIB variant
CPX-6187, Scribble cell polarity complex, DLG5-LLGL2-SCRIB variant
CPX-6188, Scribble cell polarity complex, DLG5-LLGL1-SCRIB variant
CPX-6189, Scribble cell polarity complex, DLG4-LLGL1-SCRIB variant
CPX-6190, Scribble cell polarity complex, DLG3-LLGL1-SCRIB variant
CPX-6191, Scribble cell polarity complex, DLG2-LLGL1-SCRIB variant
CPX-6192, Scribble cell polarity complex, DLG1-LLGL1-SCRIB variant

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q14160

Database of interacting proteins

More...DIPi		DIP-31259N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		Q14160

Protein interaction database and analysis system

More...IntActi		Q14160, 187 interactors

Molecular INTeraction database

More...MINTi		Q14160

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349486

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q14160, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11630
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q14160

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q14160

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati37 – 58LRR 1Add BLAST22
Repeati60 – 81LRR 2Add BLAST22
Repeati83 – 104LRR 3Add BLAST22
Repeati106 – 127LRR 4Add BLAST22
Repeati129 – 150LRR 5Add BLAST22
Repeati152 – 174LRR 6Add BLAST23
Repeati175 – 197LRR 7Add BLAST23
Repeati198 – 219LRR 8Add BLAST22
Repeati221 – 243LRR 9Add BLAST23
Repeati244 – 265LRR 10Add BLAST22
Repeati267 – 288LRR 11Add BLAST22
Repeati290 – 312LRR 12Add BLAST23
Repeati313 – 334LRR 13Add BLAST22
Repeati336 – 357LRR 14Add BLAST22
Repeati359 – 381LRR 15Add BLAST23
Repeati382 – 402LRR 16Add BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini728 – 815PDZ 1PROSITE-ProRule annotationAdd BLAST88
Domaini862 – 950PDZ 2PROSITE-ProRule annotationAdd BLAST89
Domaini1004 – 1093PDZ 3PROSITE-ProRule annotationAdd BLAST90
Domaini1100 – 1194PDZ 4PROSITE-ProRule annotationAdd BLAST95

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 818Sufficient for targeting to adherens junction and to inhibit cell proliferationAdd BLAST818
Regioni717 – 1229Interaction with ARHGEF71 PublicationAdd BLAST513
Regioni1105 – 1117Interaction with tick-borne encephalitis virus RNA-directed RNA polymerase NS51 PublicationAdd BLAST13

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili458 – 474Sequence analysisAdd BLAST17
Coiled coili656 – 701Sequence analysisAdd BLAST46
Coiled coili1379 – 1419Sequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi660 – 695Glu-richAdd BLAST36
Compositional biasi1296 – 1349Pro-richAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LAP (LRR and PDZ) protein family.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_18_20_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q14160

Database of Orthologous Groups

More...OrthoDBi		284114at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q14160

TreeFam database of animal gene trees

More...TreeFami		TF351429

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 4 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 11 hits
SM00228, PDZ, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 13 hits
PS50106, PDZ, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q14160-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKCIPLWRC NRHVESVDKR HCSLQAVPEE IYRYSRSLEE LLLDANQLRE 
        60         70         80         90        100
LPKPFFRLLN LRKLGLSDNE IQRLPPEVAN FMQLVELDVS RNDIPEIPES 
       110        120        130        140        150
IKFCKALEIA DFSGNPLSRL PDGFTQLRSL AHLALNDVSL QALPGDVGNL 
       160        170        180        190        200
ANLVTLELRE NLLKSLPASL SFLVKLEQLD LGGNDLEVLP DTLGALPNLR 
       210        220        230        240        250
ELWLDRNQLS ALPPELGNLR RLVCLDVSEN RLEELPAELG GLVLLTDLLL 
       260        270        280        290        300
SQNLLRRLPD GIGQLKQLSI LKVDQNRLCE VTEAIGDCEN LSELILTENL 
       310        320        330        340        350
LMALPRSLGK LTKLTNLNVD RNHLEALPPE IGGCVALSVL SLRDNRLAVL 
       360        370        380        390        400
PPELAHTTEL HVLDVAGNRL QSLPFALTHL NLKALWLAEN QAQPMLRFQT 
       410        420        430        440        450
EDDARTGEKV LTCYLLPQQP PPSLEDAGQQ GSLSETWSDA PPSRVSVIQF 
       460        470        480        490        500
LEAPIGDEDA EEAAAEKRGL QRRATPHPSE LKVMKRSIEG RRSEACPCQP 
       510        520        530        540        550
DSGSPLPAEE EKRLSAESGL SEDSRPSAST VSEAEPEGPS AEAQGGSQQE 
       560        570        580        590        600
ATTAGGEEDA EEDYQEPTVH FAEDALLPGD DREIEEGQPE APWTLPGGRQ 
       610        620        630        640        650
RLIRKDTPHY KKHFKISKLP QPEAVVALLQ GMQPDGEGPV APGGWHNGPH 
       660        670        680        690        700
APWAPRAQKE EEEEEEGSPQ EEEVEEEEEN RAEEEEASTE EEDKEGAVVS 
       710        720        730        740        750
APSVKGVSFD QANNLLIEPA RIEEEELTLT ILRQTGGLGI SIAGGKGSTP 
       760        770        780        790        800
YKGDDEGIFI SRVSEEGPAA RAGVRVGDKL LEVNGVALQG AEHHEAVEAL 
       810        820        830        840        850
RGAGTAVQMR VWRERMVEPE NAVTITPLRP EDDYSPRERR GGGLRLPLLP 
       860        870        880        890        900
PESPGPLRQR HVACLARSER GLGFSIAGGK GSTPYRAGDA GIFVSRIAEG 
       910        920        930        940        950
GAAHRAGTLQ VGDRVLSING VDVTEARHDH AVSLLTAASP TIALLLEREA 
       960        970        980        990       1000
GGPLPPSPLP HSSPPTAAVA TTSITTATPG VPGLPSLAPS LLAAALEGPY 
      1010       1020       1030       1040       1050
PVEEIRLPRA GGPLGLSIVG GSDHSSHPFG VQEPGVFISK VLPRGLAARS 
      1060       1070       1080       1090       1100
GLRVGDRILA VNGQDVRDAT HQEAVSALLR PCLELSLLVR RDPAPPGLRE 
      1110       1120       1130       1140       1150
LCIQKAPGER LGISIRGGAR GHAGNPRDPT DEGIFISKVS PTGAAGRDGR 
      1160       1170       1180       1190       1200
LRVGLRLLEV NQQSLLGLTH GEAVQLLRSV GDTLTVLVCD GFEASTDAAL 
      1210       1220       1230       1240       1250
EVSPGVIANP FAAGIGHRNS LESISSIDRE LSPEGPGKEK ELPGQTLHWG 
      1260       1270       1280       1290       1300
PEATEAAGRG LQPLKLDYRA LAAVPSAGSV QRVPSGAAGG KMAESPCSPS 
      1310       1320       1330       1340       1350
GQQPPSPPSP DELPANVKQA YRAFAAVPTS HPPEDAPAQP PTPGPAASPE 
      1360       1370       1380       1390       1400
QLSFRERQKY FELEVRVPQA EGPPKRVSLV GADDLRKMQE EEARKLQQKR 
      1410       1420       1430       1440       1450
AQMLREAAEA GAEARLALDG ETLGEEEQED EQPPWASPSP TSRQSPASPP 
      1460       1470       1480       1490       1500
PLGGGAPVRT AKAERRHQER LRVQSPEPPA PERALSPAEL RALEAEKRAL 
      1510       1520       1530       1540       1550
WRAARMKSLE QDALRAQMVL SRSQEGRGTR GPLERLAEAP SPAPTPSPTP 
      1560       1570       1580       1590       1600
VEDLGPQTST SPGRLSPDFA EELRSLEPSP SPGPQEEDGE VALVLLGRPS 
      1610       1620       1630
PGAVGPEDVA LCSSRRPVRP GRRGLGPVPS
Length:1,630
Mass (Da):174,885
Last modified:October 13, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD71E024FBC4F72D1
GO
Isoform 2 (identifier: Q14160-2) [UniParc]FASTAAdd to basket
Also known as: Variant N1

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:1,549
Mass (Da):165,243
Checksum:i88EE83BC4A132CD6
GO
Isoform 3 (identifier: Q14160-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1565-1565: L → LPLSGKKFDYRAFAALPSSRPVYDIQ

Show »
Length:1,655
Mass (Da):177,694
Checksum:iBF9BD19ED0A577FA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A669KB89A0A669KB89_HUMAN
Protein scribble homolog
SCRIB
1,658Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YCG0H0YCG0_HUMAN
Protein scribble homolog
SCRIB
650Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JPP5A0A0G2JPP5_HUMAN
Protein scribble homolog
SCRIB
1,655Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JNZ2A0A0G2JNZ2_HUMAN
Protein scribble homolog
SCRIB
1,630Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JMS7A0A0G2JMS7_HUMAN
Protein scribble homolog
SCRIB
1,549Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A669KAX5A0A669KAX5_HUMAN
Protein scribble homolog
SCRIB
214Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YDF9H0YDF9_HUMAN
Protein scribble homolog
SCRIB
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti674V → E in AAP88017 (PubMed:15649318).Curated1
Sequence conflicti674V → E in AAL38976 (PubMed:15806148).Curated1
Sequence conflicti674V → E in AAP88018 (Ref. 3) Curated1
Sequence conflicti674V → E in BAA09768 (PubMed:8590280).Curated1
Sequence conflicti1489E → K in AAL38976 (PubMed:15806148).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019429422P → L4 PublicationsCorresponds to variant dbSNP:rs6558394Ensembl.1
Natural variantiVAR_067219454P → S in NTD; protein interactions not affected by the mutation; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs1302482009Ensembl.1
Natural variantiVAR_0672201535R → Q in NTD; protein interactions not affected by the mutation; shows reduced protein localization to the cell membrane. 1 PublicationCorresponds to variant dbSNP:rs782428100Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0109061 – 81Missing in isoform 2. 1 PublicationAdd BLAST81
Alternative sequenceiVSP_0109081565L → LPLSGKKFDYRAFAALPSSR PVYDIQ in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF240677 mRNA Translation: AAP88017.1
AY062238 mRNA Translation: AAL38976.1
AF271734 mRNA Translation: AAP88018.2
D63481 mRNA Translation: BAA09768.3
AC105219 Genomic DNA No translation available.
BC009490 mRNA Translation: AAH09490.2
BC014632 mRNA Translation: AAH14632.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6411.1 [Q14160-1]
CCDS6412.1 [Q14160-3]

NCBI Reference Sequences

More...RefSeqi		NP_056171.3, NM_015356.4
NP_874365.3, NM_182706.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000320476; ENSP00000322938; ENSG00000180900
ENST00000356994; ENSP00000349486; ENSG00000180900
ENST00000377533; ENSP00000366756; ENSG00000180900

Database of genes from NCBI RefSeq genomes

More...GeneIDi		23513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:23513

UCSC genome browser

More...UCSCi		uc003yzo.1, human [Q14160-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240677 mRNA Translation: AAP88017.1
AY062238 mRNA Translation: AAL38976.1
AF271734 mRNA Translation: AAP88018.2
D63481 mRNA Translation: BAA09768.3
AC105219 Genomic DNA No translation available.
BC009490 mRNA Translation: AAH09490.2
BC014632 mRNA Translation: AAH14632.2
CCDSiCCDS6411.1 [Q14160-1]
CCDS6412.1 [Q14160-3]
RefSeqiNP_056171.3, NM_015356.4
NP_874365.3, NM_182706.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJUNMR-A1096-1193[»]
1WHANMR-A860-951[»]
1X5QNMR-A718-814[»]
2W4FX-ray1.30A725-815[»]
4WYTX-ray2.60A992-1203[»]
4WYUX-ray2.50A/B992-1203[»]
5VWCX-ray1.91A725-815[»]
5VWIX-ray1.75A/B1002-1092[»]
5VWKX-ray2.35A/B/C/D700-816[»]
6EEYX-ray1.15A1098-1189[»]
6ESPNMR-A719-829[»]
6MS1X-ray1.35A/B722-815[»]
6MTUX-ray2.14A/B700-816[»]
6MTVX-ray2.60A/B700-816[»]
6MYEX-ray1.10A725-815[»]
6MYFX-ray1.60A725-815[»]
SMRiQ14160
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi117060, 101 interactors
ComplexPortaliCPX-6168, Scribble cell polarity complex, DLG1-LLGL2-SCRIB variant
CPX-6184, Scribble cell polarity complex, DLG2-LLGL2-SCRIB variant
CPX-6185, Scribble cell polarity complex, DLG3-LLGL2-SCRIB variant
CPX-6186, Scribble cell polarity complex, DLG4-LLGL2-SCRIB variant
CPX-6187, Scribble cell polarity complex, DLG5-LLGL2-SCRIB variant
CPX-6188, Scribble cell polarity complex, DLG5-LLGL1-SCRIB variant
CPX-6189, Scribble cell polarity complex, DLG4-LLGL1-SCRIB variant
CPX-6190, Scribble cell polarity complex, DLG3-LLGL1-SCRIB variant
CPX-6191, Scribble cell polarity complex, DLG2-LLGL1-SCRIB variant
CPX-6192, Scribble cell polarity complex, DLG1-LLGL1-SCRIB variant
CORUMiQ14160
DIPiDIP-31259N
ELMiQ14160
IntActiQ14160, 187 interactors
MINTiQ14160
STRINGi9606.ENSP00000349486

Protein family/group databases

MoonDBiQ14160, Predicted

PTM databases

GlyGeniQ14160, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ14160
PhosphoSitePlusiQ14160
SwissPalmiQ14160

Genetic variation databases

BioMutaiSCRIB
DMDMi261260101

Proteomic databases

EPDiQ14160
jPOSTiQ14160
MassIVEiQ14160
MaxQBiQ14160
PaxDbiQ14160
PeptideAtlasiQ14160
PRIDEiQ14160
ProteomicsDBi59873 [Q14160-1]
59874 [Q14160-2]
59875 [Q14160-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		43533, 133 antibodies

The DNASU plasmid repository

More...DNASUi		23513

Genome annotation databases

EnsembliENST00000320476; ENSP00000322938; ENSG00000180900
ENST00000356994; ENSP00000349486; ENSG00000180900
ENST00000377533; ENSP00000366756; ENSG00000180900
GeneIDi23513
KEGGihsa:23513
UCSCiuc003yzo.1, human [Q14160-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		23513
DisGeNETi23513

GeneCards: human genes, protein and diseases

More...GeneCardsi		SCRIB
HGNCiHGNC:30377, SCRIB
HPAiENSG00000180900, Low tissue specificity
MalaCardsiSCRIB
MIMi182940, phenotype
607733, gene
neXtProtiNX_Q14160
PharmGKBiPA134936275
VEuPathDBiHostDB:ENSG00000180900.16

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
HOGENOMiCLU_000288_18_20_1
InParanoidiQ14160
OrthoDBi284114at2759
PhylomeDBiQ14160
TreeFamiTF351429

Enzyme and pathway databases

PathwayCommonsiQ14160
ReactomeiR-HSA-4608870, Asymmetric localization of PCP proteins
SignaLinkiQ14160

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		23513, 24 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SCRIB, human
EvolutionaryTraceiQ14160

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SCRIB

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		23513
PharosiQ14160, Tbio

Protein Ontology

More...PROi		PR:Q14160
RNActiQ14160, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000180900, Expressed in lower esophagus mucosa and 211 other tissues
ExpressionAtlasiQ14160, baseline and differential
GenevisibleiQ14160, HS

Family and domain databases

Gene3Di2.30.42.10, 4 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF13855, LRR_8, 2 hits
PF00595, PDZ, 4 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 11 hits
SM00228, PDZ, 4 hits
SUPFAMiSSF50156, SSF50156, 4 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 13 hits
PS50106, PDZ, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCRIB_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q14160
Secondary accession number(s): Q6P496
, Q7Z5D1, Q8WWV8, Q96C69, Q96GG1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 13, 2009
Last modified: April 7, 2021
This is version 212 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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