Q13635 · PTC1_HUMAN
- ProteinProtein patched homolog 1
- GenePTCH1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1447 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Keywords
- Molecular function
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProtein patched homolog 1
- Short namesPTC; PTC1
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ13635
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-100 | Cytoplasmic | ||||
Sequence: MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGK | ||||||
Transmembrane | 101-121 | Helical | ||||
Sequence: FLVVGLLIFGAFAVGLKAANL | ||||||
Topological domain | 122-436 | Extracellular | ||||
Sequence: ETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSD | ||||||
Transmembrane | 437-457 | Helical | ||||
Sequence: VSVIRVASGYLLMLAYACLTM | ||||||
Topological domain | 458-472 | Cytoplasmic | ||||
Sequence: LRWDCSKSQGAVGLA | ||||||
Transmembrane | 473-493 | Helical | ||||
Sequence: GVLLVALSVAAGLGLCSLIGI | ||||||
Topological domain | 494-501 | Extracellular | ||||
Sequence: SFNAATTQ | ||||||
Transmembrane | 502-522 | Helical | ||||
Sequence: VLPFLALGVGVDDVFLLAHAF | ||||||
Topological domain | 523-547 | Cytoplasmic | ||||
Sequence: SETGQNKRIPFEDRTGECLKRTGAS | ||||||
Transmembrane | 548-568 | Helical | ||||
Sequence: VALTSISNVTAFFMAALIPIP | ||||||
Topological domain | 569-577 | Extracellular | ||||
Sequence: ALRAFSLQA | ||||||
Transmembrane | 578-598 | Helical | ||||
Sequence: AVVVVFNFAMVLLIFPAILSM | ||||||
Topological domain | 599-748 | Cytoplasmic | ||||
Sequence: DLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPK | ||||||
Transmembrane | 749-769 | Helical | ||||
Sequence: AKVVVIFLFLGLLGVSLYGTT | ||||||
Topological domain | 770-1027 | Extracellular | ||||
Sequence: RVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHW | ||||||
Transmembrane | 1028-1048 | Helical | ||||
Sequence: LLLFISVVLACTFLVCAVFLL | ||||||
Topological domain | 1049-1055 | Cytoplasmic | ||||
Sequence: NPWTAGI | ||||||
Transmembrane | 1056-1076 | Helical | ||||
Sequence: IVMVLALMTVELFGMMGLIGI | ||||||
Topological domain | 1077-1083 | Extracellular | ||||
Sequence: KLSAVPV | ||||||
Transmembrane | 1084-1104 | Helical | ||||
Sequence: VILIASVGIGVEFTVHVALAF | ||||||
Topological domain | 1105-1121 | Cytoplasmic | ||||
Sequence: LTAIGDKNRRAVLALEH | ||||||
Transmembrane | 1122-1141 | Helical | ||||
Sequence: MFAPVLDGAVSTLLGVLMLA | ||||||
Topological domain | 1142-1154 | Extracellular | ||||
Sequence: GSEFDFIVRYFFA | ||||||
Transmembrane | 1155-1175 | Helical | ||||
Sequence: VLAILTILGVLNGLVLLPVLL | ||||||
Topological domain | 1176-1447 | Cytoplasmic | ||||
Sequence: SFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Basal cell nevus syndrome 1 (BCNS1)
- Note
- DescriptionA form of basal cell nevus syndrome, a disease characterized by nevoid basal cell carcinomas and developmental abnormalities such as rib and craniofacial alterations, polydactyly, syndactyly, and spina bifida. In addition, the patients suffer from a multitude of tumors like fibromas of the ovaries and heart, cysts of the skin, jaws and mesentery, as well as medulloblastomas and meningiomas. BCNS1 inheritance is autosomal dominant.
- See alsoMIM:109400
Natural variants in BCNS1
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_007843 | 175 | L>P | in BCNS1; dbSNP:rs2118541066 | |
VAR_020845 | 230 | T>P | in BCNS1; dbSNP:rs2118464571 | |
VAR_007844 | 376 | F>S | in BCNS1 | |
VAR_020846 | 505-506 | FL>LR | in BCNS1 | |
VAR_010974 | 509 | G>R | in BCNS1; uncertain significance; dbSNP:rs2118285458 | |
VAR_010975 | 509 | G>V | in BCNS1; dbSNP:rs1060502268 | |
VAR_010976 | 513 | D>Y | in BCNS1 | |
VAR_007845 | 815 | I>IPNI | in BCNS1 | |
VAR_010977 | 816 | missing | in BCNS1 | |
VAR_010979 | 1069 | G>R | in BCNS1; dbSNP:rs2136649648 | |
VAR_007846 | 1083 | V>VV | in BCNS1 | |
VAR_007847 | 1114 | R>W | in BCNS1 and BCC; dbSNP:rs587776689 | |
VAR_010980 | 1132 | S>P | in BCNS1; dbSNP:rs878853856 | |
VAR_010981 | 1132 | S>Y | in BCNS1 | |
VAR_010984 | 1438 | E>D | in BCNS1 |
Basal cell carcinoma (BCC)
- Note
- DescriptionA common malignant skin neoplasm that typically appears on hair-bearing skin, most commonly on sun-exposed areas. BCC is slow growing and rarely metastasizes, but has potentialities for local invasion and destruction. It usually develops as a flat, firm, pale area that is small, raised, pink or red, translucent, shiny, and waxy, and the area may bleed following minor injury. Tumor size can vary from a few millimeters to several centimeters in diameter.
- See alsoMIM:605462
Natural variants in BCC
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_007847 | 1114 | R>W | in BCNS1 and BCC; dbSNP:rs587776689 |
Holoprosencephaly 7 (HPE7)
- Note
- DescriptionA structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
- See alsoMIM:610828
Natural variants in HPE7
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_032952 | 393 | A>T | in HPE7; dbSNP:rs199476091 | |
VAR_032953 | 443 | A>G | in HPE7; dbSNP:rs878853845 | |
VAR_032954 | 728 | T>M | in HPE7; dbSNP:rs115556836 | |
VAR_032955 | 751 | V>G | in HPE7 | |
VAR_032956 | 827 | S>G | in HPE7; dbSNP:rs199476092 | |
VAR_032957 | 908 | V>G | in HPE7; dbSNP:rs199476093 | |
VAR_032958 | 1052 | T>M | in HPE7; dbSNP:rs138911275 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_007843 | 175 | in BCNS1; dbSNP:rs2118541066 | |||
Sequence: L → P | ||||||
Natural variant | VAR_020845 | 230 | in BCNS1; dbSNP:rs2118464571 | |||
Sequence: T → P | ||||||
Natural variant | VAR_007844 | 376 | in BCNS1 | |||
Sequence: F → S | ||||||
Natural variant | VAR_032952 | 393 | in HPE7; dbSNP:rs199476091 | |||
Sequence: A → T | ||||||
Natural variant | VAR_032953 | 443 | in HPE7; dbSNP:rs878853845 | |||
Sequence: A → G | ||||||
Natural variant | VAR_020846 | 505-506 | in BCNS1 | |||
Sequence: FL → LR | ||||||
Natural variant | VAR_010974 | 509 | in BCNS1; uncertain significance; dbSNP:rs2118285458 | |||
Sequence: G → R | ||||||
Natural variant | VAR_010975 | 509 | in BCNS1; dbSNP:rs1060502268 | |||
Sequence: G → V | ||||||
Natural variant | VAR_010976 | 513 | in BCNS1 | |||
Sequence: D → Y | ||||||
Natural variant | VAR_032954 | 728 | in HPE7; dbSNP:rs115556836 | |||
Sequence: T → M | ||||||
Natural variant | VAR_032955 | 751 | in HPE7 | |||
Sequence: V → G | ||||||
Natural variant | VAR_007845 | 815 | in BCNS1 | |||
Sequence: I → IPNI | ||||||
Natural variant | VAR_010977 | 816 | in BCNS1 | |||
Sequence: Missing | ||||||
Natural variant | VAR_032956 | 827 | in HPE7; dbSNP:rs199476092 | |||
Sequence: S → G | ||||||
Natural variant | VAR_010978 | 829 | in squamous cell carcinoma; dbSNP:rs201125580 | |||
Sequence: V → M | ||||||
Natural variant | VAR_032957 | 908 | in HPE7; dbSNP:rs199476093 | |||
Sequence: V → G | ||||||
Natural variant | VAR_032958 | 1052 | in HPE7; dbSNP:rs138911275 | |||
Sequence: T → M | ||||||
Natural variant | VAR_010979 | 1069 | in BCNS1; dbSNP:rs2136649648 | |||
Sequence: G → R | ||||||
Natural variant | VAR_007846 | 1083 | in BCNS1 | |||
Sequence: V → VV | ||||||
Natural variant | VAR_007847 | 1114 | in BCNS1 and BCC; dbSNP:rs587776689 | |||
Sequence: R → W | ||||||
Natural variant | VAR_010980 | 1132 | in BCNS1; dbSNP:rs878853856 | |||
Sequence: S → P | ||||||
Natural variant | VAR_010981 | 1132 | in BCNS1 | |||
Sequence: S → Y | ||||||
Natural variant | VAR_020440 | 1195 | in dbSNP:rs2236405 | |||
Sequence: T → S | ||||||
Natural variant | VAR_010982 | 1242 | in squamous cell carcinoma; dbSNP:rs779417284 | |||
Sequence: E → K | ||||||
Natural variant | VAR_020847 | 1282 | in dbSNP:rs2227968 | |||
Sequence: P → L | ||||||
Natural variant | VAR_010983 | 1315 | in dbSNP:rs357564 | |||
Sequence: P → L | ||||||
Natural variant | VAR_010984 | 1438 | in BCNS1 | |||
Sequence: E → D |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 5,686 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, glycosylation, modified residue, modified residue (large scale data), cross-link.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000205964 | 1-1447 | UniProt | Protein patched homolog 1 | |||
Sequence: MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQISKGKATGRKAPLWLRAKFQRLLFKLGCYIQKNCGKFLVVGLLIFGAFAVGLKAANLETNVEELWVEVGGRVSRELNYTRQKIGEEAMFNPQLMIQTPKEEGANVLTTEALLQHLDSALQASRVHVYMYNRQWKLEHLCYKSGELITETGYMDQIIEYLYPCLIITPLDCFWEGAKLQSGTAYLLGKPPLRWTNFDPLEFLEELKKINYQVDSWEEMLNKAEVGHGYMDRPCLNPADPDCPATAPNKNSTKPLDMALVLNGGCHGLSRKYMHWQEELIVGGTVKNSTGKLVSAHALQTMFQLMTPKQMYEHFKGYEYVSHINWNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTTTLDDILKSFSDVSVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCCFTSPCVSRVIQVEPQAYTDTHDNTRYSPPPPYSSHSFAHETQITMQSTVQLRTEYDPHTHVYYTTAEPRSEISVQPVTVTQDTLSCQSPESTSSTRDLLSQFSDSSLHCLEPPCTKWTLSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFIAAQFKYFSFYNMYIVTQKADYPNIQHLLYDLHRSFSNVKYVMLEENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGSDDGVLAYKLLVQTGSRDKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKADYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYTSLGLSSYPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFLLNPWTAGIIVMVLALMTVELFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAIGDKNRRAVLALEHMFAPVLDGAVSTLLGVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGPYPEVSPANGLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGLSEELRHYEAQQGAGGPAHQVIVEATENPVFAHSTVVHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSSVPGYCQPITTVTASASVTVAVHPPPVPGPGRNPRGGLCPGYPETDHGLFEDPHVPFHVRCERRDSKVEVIELQDVECEERPRGSSSN | |||||||
Glycosylation | 141 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 312 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 349 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 414 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 875 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 1000 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue | 1195 | UniProt | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 1195 | PRIDE | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue | 1197 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 1197 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Cross-link | 1426 | UniProt | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Developmental stage
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with IHH (PubMed:21537345).
Interacts with G-protein coupled receptor GPR37L1 (By similarity).
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-43 | Disordered | ||||
Sequence: MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAA | ||||||
Domain | 438-598 | SSD | ||||
Sequence: SVIRVASGYLLMLAYACLTMLRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATTQVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFFMAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSM | ||||||
Region | 1189-1234 | Disordered | ||||
Sequence: GLNRLPTPSPEPPPSVVRFAMPPGHTHSGSDSSDSEYSSQTTVSGL | ||||||
Compositional bias | 1193-1207 | Pro residues | ||||
Sequence: LPTPSPEPPPSVVRF | ||||||
Compositional bias | 1214-1234 | Polar residues | ||||
Sequence: THSGSDSSDSEYSSQTTVSGL | ||||||
Region | 1270-1360 | Disordered | ||||
Sequence: VHPESRHHPPSNPRQQPHLDSGSLPPGRQGQQPRRDPPREGLWPPPYRPRRDAFEISTEGHSGPSNRARWGPRGARSHNPRNPASTAMGSS |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q13635-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameL
- Synonyms1B
- Length1,447
- Mass (Da)160,545
- Last updated2007-10-23 v2
- ChecksumF2937247BC812F85
Q13635-2
- NameL'
- Synonyms1Ckid
- Differences from canonical
- 1-66: MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQIS → MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDKETRSD
Q13635-3
- NameM
- Synonyms1C
- Differences from canonical
- 2-67: Missing
Q13635-4
- NameS
- Synonyms1A, 1CdeltaE2
- Differences from canonical
- 2-152: Missing
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
H0YHK0 | H0YHK0_HUMAN | PTCH1 | 16 | ||
F8VXL8 | F8VXL8_HUMAN | PTCH1 | 66 | ||
H3BLX7 | H3BLX7_HUMAN | PTCH1 | 486 | ||
F8VQS6 | F8VQS6_HUMAN | PTCH1 | 92 | ||
F8VPA3 | F8VPA3_HUMAN | PTCH1 | 79 | ||
H0Y3B8 | H0Y3B8_HUMAN | PTCH1 | 352 | ||
A0A8I5KPP5 | A0A8I5KPP5_HUMAN | PTCH1 | 456 | ||
A0A0C4DGI4 | A0A0C4DGI4_HUMAN | PTCH1 | 174 | ||
A0A0C4DGJ5 | A0A0C4DGJ5_HUMAN | PTCH1 | 183 |
Features
Showing features for alternative sequence, sequence conflict, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_041369 | 1-66 | in isoform L' | |||
Sequence: MASAGNAAEPQDRGGGGSGCIGAPGRPAGGGRRRRTGGLRRAAAPDRDYLHRPSYCDAAFALEQIS → MELLNRNRLVIVSPRCTPPKASGGPARRGFYTFRSFCKDGGGGEEEEENGGEEKDDRGDKETRSD | ||||||
Alternative sequence | VSP_041371 | 2-67 | in isoform M | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_041370 | 2-152 | in isoform S | |||
Sequence: Missing | ||||||
Sequence conflict | 1109 | in Ref. 2; AAC50496 | ||||
Sequence: G → S | ||||||
Sequence conflict | 1144 | in Ref. 2; AAC50496 | ||||
Sequence: E → D | ||||||
Sequence conflict | 1175 | in Ref. 2; AAC50496 | ||||
Sequence: L → W | ||||||
Compositional bias | 1193-1207 | Pro residues | ||||
Sequence: LPTPSPEPPPSVVRF | ||||||
Compositional bias | 1214-1234 | Polar residues | ||||
Sequence: THSGSDSSDSEYSSQTTVSGL | ||||||
Sequence conflict | 1283 | in Ref. 2; AAC50496 | ||||
Sequence: R → K | ||||||
Sequence conflict | 1309 | in Ref. 2; AAC50496 | ||||
Sequence: E → K | ||||||
Sequence conflict | 1353 | in Ref. 2; AAC50496 | ||||
Sequence: A → T |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U59464 EMBL· GenBank· DDBJ | AAC50550.1 EMBL· GenBank· DDBJ | mRNA | ||
U43148 EMBL· GenBank· DDBJ | AAC50496.1 EMBL· GenBank· DDBJ | mRNA | ||
AL161729 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AB189436 EMBL· GenBank· DDBJ | BAD74184.1 EMBL· GenBank· DDBJ | mRNA | ||
AB189437 EMBL· GenBank· DDBJ | BAD74185.1 EMBL· GenBank· DDBJ | mRNA | ||
AB189438 EMBL· GenBank· DDBJ | BAD74186.1 EMBL· GenBank· DDBJ | mRNA | ||
AB189439 EMBL· GenBank· DDBJ | BAD74187.1 EMBL· GenBank· DDBJ | mRNA | ||
AB189440 EMBL· GenBank· DDBJ | BAD74188.1 EMBL· GenBank· DDBJ | mRNA | ||
BC043542 EMBL· GenBank· DDBJ | AAH43542.1 EMBL· GenBank· DDBJ | mRNA | ||
AB239329 EMBL· GenBank· DDBJ | BAF47712.1 EMBL· GenBank· DDBJ | mRNA |