Q13610 · PWP1_HUMAN

  • Protein
    Periodic tryptophan protein 1 homolog
  • Gene
    PWP1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Chromatin-associated factor that regulates transcription (PubMed:29065309).
Regulates Pol I-mediated rRNA biogenesis and, probably, Pol III-mediated transcription (PubMed:29065309).
Regulates the epigenetic status of rDNA (PubMed:29065309).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome
Cellular ComponentGolgi apparatus
Cellular Componentnucleolus
Cellular Componentnucleus
Molecular FunctionH4K20me3 modified histone binding
Molecular Functionhistone chaperone activity
Biological ProcessDNA-templated transcription
Biological Processnegative regulation of peptidyl-serine phosphorylation of STAT protein
Biological Processpositive regulation of stem cell differentiation
Biological Processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
Biological ProcessrRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Periodic tryptophan protein 1 homolog
  • Alternative names
    • Keratinocyte protein IEF SSP 9502

Gene names

    • Name
      PWP1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q13610
  • Secondary accessions
    • A8K3R6
    • Q7Z3X9

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Nucleus, nucleolus
Chromosome
Note: Associates with chromatin regions of rDNA.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_033808288in dbSNP:rs11547907

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 528 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00000511711-501UniProtPeriodic tryptophan protein 1 homolog
Modified residue21UniProtPhosphothreonine
Modified residue (large scale data)21PRIDEPhosphothreonine
Modified residue50UniProtPhosphoserine
Modified residue (large scale data)50PRIDEPhosphoserine
Modified residue55UniProtPhosphothreonine
Modified residue (large scale data)55PRIDEPhosphothreonine
Modified residue57UniProtPhosphoserine
Modified residue (large scale data)57PRIDEPhosphoserine
Modified residue59UniProtPhosphoserine
Modified residue (large scale data)59PRIDEPhosphoserine
Modified residue86UniProtPhosphothreonine
Modified residue (large scale data)86PRIDEPhosphothreonine
Modified residue (large scale data)138PRIDEPhosphotyrosine
Modified residue (large scale data)484PRIDEPhosphoserine
Modified residue485UniProtPhosphoserine
Modified residue (large scale data)485PRIDEPhosphoserine
Modified residue494UniProtPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

High levels seen in the placenta, skeletal muscle, kidney and pancreas while lower levels were seen in the heart, brain and lung.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Associates with the RNA polymerase (Pol I) complex (PubMed:29065309).
Interacts with POLR1E (PubMed:29065309).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, repeat.

TypeIDPosition(s)Description
Region38-89Disordered
Repeat116-171WD 1
Repeat177-222WD 2
Repeat247-286WD 3
Repeat290-329WD 4
Repeat334-372WD 5
Repeat376-415WD 6
Repeat421-460WD 7

Sequence similarities

Belongs to the WD repeat PWP1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q13610-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    501
  • Mass (Da)
    55,828
  • Last updated
    1996-11-01 v1
  • Checksum
    16CC8EF2BAC8DFF0
MNRSRQVTCVAWVRCGVAKETPDKVELSKEEVKRLIAEAKEKLQEEGGGSDEEETGSPSEDGMQSARTQARPREPLEDGDPEDDRTLDDDELAEYDLDKYDEEGDPDAETLGESLLGLTVYGSNDQDPYVTLKDTEQYEREDFLIKPSDNLIVCGRAEQDQCNLEVHVYNQEEDSFYVHHDILLSAYPLSVEWLNFDPSPDDSTGNYIAVGNMTPVIEVWDLDIVDSLEPVFTLGSKLSKKKKKKGKKSSSAEGHTDAVLDLSWNKLIRNVLASASADNTVILWDMSLGKPAASLAVHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRSPDESHRMWRFSGQIERVTWNHFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASADKYVKIWDILGDRPSLVHSRDMKMGVLFCSSCCPDLPFIYAFGGQKEGLRVWDISTVSSVNEAFGRRERLVLGSARNSSISGPFGSRSSDTPMES

Q13610-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F8VZ56F8VZ56_HUMANPWP198
B4DJV5B4DJV5_HUMANPWP1439

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_056168136-147in isoform 2
Alternative sequenceVSP_056169148-501in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L07758
EMBL· GenBank· DDBJ
AAA65201.1
EMBL· GenBank· DDBJ
mRNA
AK290681
EMBL· GenBank· DDBJ
BAF83370.1
EMBL· GenBank· DDBJ
mRNA
AC007622
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471054
EMBL· GenBank· DDBJ
EAW97802.1
EMBL· GenBank· DDBJ
Genomic DNA
BC010921
EMBL· GenBank· DDBJ
AAH10921.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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