Q053V6 · SUCC_LEPBL

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site50ATP (UniProtKB | ChEBI)
Binding site57-59ATP (UniProtKB | ChEBI)
Binding site103ATP (UniProtKB | ChEBI)
Binding site106ATP (UniProtKB | ChEBI)
Binding site111ATP (UniProtKB | ChEBI)
Binding site203Mg2+ (UniProtKB | ChEBI)
Binding site217Mg2+ (UniProtKB | ChEBI)
Binding site268substrate; ligand shared with subunit alpha
Binding site325-327substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentsuccinate-CoA ligase complex
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit beta
      (SCS-beta
      )

Gene names

    • Name
      sucC
    • Ordered locus names
      LBL_0834

Organism names

Accessions

  • Primary accession
    Q053V6

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000821171-390Succinate--CoA ligase [ADP-forming] subunit beta

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-248ATP-grasp

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    41,982
  • Last updated
    2006-11-14 v1
  • Checksum
    068737440DF3532A
MKIHEYQAKEILRRHKANVPFGIVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGKGGGVKVTKTKEDATAAVDKILGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDRSIRKTILMASTEGGMEIEEVAETHPEKILKIAVDPGIGLQVNQARQLAFELGLPAESHKSFQSLVMAIYDAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDITEEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKTTVTNGFKIILGDPNVKGIFVNIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSELGREVLNKSGLKITGVDDLREAASTIAKLIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000348
EMBL· GenBank· DDBJ
ABJ78389.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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