Q00422 · GABPA_MOUSE

  • Protein
    GA-binding protein alpha chain
  • Gene
    Gabpa
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcription factor capable of interacting with purine rich repeats (GA repeats). Positively regulates transcription of transcriptional repressor Rhit/Zpf13.

Features

Showing features for dna binding.

145450100150200250300350400450
TypeIDPosition(s)Description
DNA binding320-400ETS

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processblastocyst formation
Biological Processin utero embryonic development
Biological Processnegative regulation of megakaryocyte differentiation
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GA-binding protein alpha chain
  • Short names
    GABP subunit alpha

Gene names

    • Name
      Gabpa
    • Synonyms
      E4tf1a

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q00422
  • Secondary accessions
    • Q7TT22

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue (large scale data), modified residue.

Type
IDPosition(s)Source
Description
ChainPRO_00002041281-454UniProtGA-binding protein alpha chain
Modified residue (large scale data)282PTMeXchangePhosphothreonine
Modified residue (large scale data)299PTMeXchangePhosphoserine
Modified residue303UniProtPhosphoserine
Modified residue (large scale data)303PTMeXchangePhosphoserine
Modified residue (large scale data)309PTMeXchangePhosphoserine
Modified residue (large scale data)447PTMeXchangePhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous.

Gene expression databases

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain168-251PNT
Region295-316Disordered

Sequence similarities

Belongs to the ETS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    454
  • Mass (Da)
    51,344
  • Last updated
    2011-07-27 v2
  • MD5 Checksum
    C780EA6874DC8EB39F31DC59D131ACC2
MTKREAEELIEIEIDGTEKAECTEESIVEQTYTPAECVSQAIDINEPIGNLKKLLEPRLQCSLDAHEICLQDIQLDPDRSLFDQGVKTDGTVQLSVQVISYQGMEPKLNILEIVKTAETVEVVIDPDAHHAEAEAHLVEEAQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERLGIPYDPIHWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVPPATPTTIKVINSSAKAAKVQRSPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVIECEQKKLARMQLHGIAQPVTAVALAATSLQADKEI

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict188in Ref. 1; AAA53030

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M74515
EMBL· GenBank· DDBJ
AAA53030.1
EMBL· GenBank· DDBJ
mRNA
AK139916
EMBL· GenBank· DDBJ
BAE24181.1
EMBL· GenBank· DDBJ
mRNA
AK145446
EMBL· GenBank· DDBJ
BAE26442.1
EMBL· GenBank· DDBJ
mRNA
AK145838
EMBL· GenBank· DDBJ
BAE26687.1
EMBL· GenBank· DDBJ
mRNA
AK148087
EMBL· GenBank· DDBJ
BAE28337.1
EMBL· GenBank· DDBJ
mRNA
AK150455
EMBL· GenBank· DDBJ
BAE29575.1
EMBL· GenBank· DDBJ
mRNA
CH466521
EMBL· GenBank· DDBJ
EDK98317.1
EMBL· GenBank· DDBJ
Genomic DNA
BC052448
EMBL· GenBank· DDBJ
AAH52448.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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