UniProtKB - P9WQD7 (FAB2_MYCTU)
Protein
3-oxoacyl-[acyl-carrier-protein] synthase 2
Gene
kasB
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.By similarity
Catalytic activityi
- EC:2.3.1.41
: fatty acid biosynthesis Pathwayi
This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 170 | By similarity | 1 | |
Binding sitei | 311 | SubstrateBy similarity | 1 | |
Binding sitei | 346 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: MTBBASE
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
- fatty acid elongation Source: MTBBASE
- mycolic acid biosynthetic process Source: MTBBASE
- response to hypoxia Source: MTBBASE
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Enzyme and pathway databases
BioCyci | MetaCyc:G185E-6462-MONOMER MTBH37RV:G185E-6462-MONOMER |
UniPathwayi | UPA00094 |
Chemistry databases
SwissLipidsi | SLP:000000963 |
Names & Taxonomyi
Protein namesi | Recommended name: 3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.41)Alternative name(s): Beta-ketoacyl-ACP synthase 2 Short name: KAS 2 |
Gene namesi | Name:kasB Ordered Locus Names:Rv2246 ORF Names:MTCY427.27 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2246 |
Subcellular locationi
- Cytoplasm Curated
GO - Cellular componenti
- cell wall Source: MTBBASE
- cytosol Source: GO_Central
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000180334 | 1 – 417 | 3-oxoacyl-[acyl-carrier-protein] synthase 2Add BLAST | 417 |
Proteomic databases
PaxDbi | P9WQD7 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 83332.Rv2246 |
Chemistry databases
BindingDBi | P9WQD7 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P9WQD7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105C0Q Bacteria COG0304 LUCA |
KOi | K11609 |
OMAi | QIGHCLG |
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794 Beta-ketoacyl_synthase IPR014031 Ketoacyl_synth_C IPR014030 Ketoacyl_synth_N IPR020841 PKS_Beta-ketoAc_synthase_dom IPR016039 Thiolase-like |
PANTHERi | PTHR11712 PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109 ketoacyl-synt, 1 hit PF02801 Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825 PKS_KS, 1 hit |
SUPFAMi | SSF53901 SSF53901, 2 hits |
i Sequence
Sequence statusi: Complete.
P9WQD7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTELVTGKAF PYVVVTGIAM TTALATDAET TWKLLLDRQS GIRTLDDPFV
60 70 80 90 100
EEFDLPVRIG GHLLEEFDHQ LTRIELRRMG YLQRMSTVLS RRLWENAGSP
110 120 130 140 150
EVDTNRLMVS IGTGLGSAEE LVFSYDDMRA RGMKAVSPLT VQKYMPNGAA
160 170 180 190 200
AAVGLERHAK AGVMTPVSAC ASGAEAIARA WQQIVLGEAD AAICGGVETR
210 220 230 240 250
IEAVPIAGFA QMRIVMSTNN DDPAGACRPF DRDRDGFVFG EGGALLLIET
260 270 280 290 300
EEHAKARGAN ILARIMGASI TSDGFHMVAP DPNGERAGHA ITRAIQLAGL
310 320 330 340 350
APGDIDHVNA HATGTQVGDL AEGRAINNAL GGNRPAVYAP KSALGHSVGA
360 370 380 390 400
VGAVESILTV LALRDQVIPP TLNLVNLDPE IDLDVVAGEP RPGNYRYAIN
410
NSFGFGGHNV AIAFGRY
Sequence cautioni
The sequence CCP45026 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45026.1 Different initiation. |
PIRi | B70779 |
RefSeqi | NP_216762.1, NC_000962.3 |
Genome annotation databases
EnsemblBacteriai | CCP45026; CCP45026; Rv2246 |
GeneIDi | 887539 |
KEGGi | mtu:Rv2246 |
PATRICi | fig|83332.12.peg.2504 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45026.1 Different initiation. |
PIRi | B70779 |
RefSeqi | NP_216762.1, NC_000962.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2GP6 | X-ray | 2.40 | A/B | 5-417 | [»] | |
SMRi | P9WQD7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv2246 |
Chemistry databases
BindingDBi | P9WQD7 |
ChEMBLi | CHEMBL4543 |
SwissLipidsi | SLP:000000963 |
Proteomic databases
PaxDbi | P9WQD7 |
Genome annotation databases
EnsemblBacteriai | CCP45026; CCP45026; Rv2246 |
GeneIDi | 887539 |
KEGGi | mtu:Rv2246 |
PATRICi | fig|83332.12.peg.2504 |
Organism-specific databases
TubercuListi | Rv2246 |
Phylogenomic databases
eggNOGi | ENOG4105C0Q Bacteria COG0304 LUCA |
KOi | K11609 |
OMAi | QIGHCLG |
Enzyme and pathway databases
UniPathwayi | UPA00094 |
BioCyci | MetaCyc:G185E-6462-MONOMER MTBH37RV:G185E-6462-MONOMER |
Miscellaneous databases
PROi | PR:P9WQD7 |
Family and domain databases
Gene3Di | 3.40.47.10, 2 hits |
InterProi | View protein in InterPro IPR000794 Beta-ketoacyl_synthase IPR014031 Ketoacyl_synth_C IPR014030 Ketoacyl_synth_N IPR020841 PKS_Beta-ketoAc_synthase_dom IPR016039 Thiolase-like |
PANTHERi | PTHR11712 PTHR11712, 1 hit |
Pfami | View protein in Pfam PF00109 ketoacyl-synt, 1 hit PF02801 Ketoacyl-synt_C, 1 hit |
SMARTi | View protein in SMART SM00825 PKS_KS, 1 hit |
SUPFAMi | SSF53901 SSF53901, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FAB2_MYCTU | |
Accessioni | P9WQD7Primary (citable) accession number: P9WQD7 Secondary accession number(s): L0TBY1, P63456, Q10525 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 39 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references