P9WNS4 · DUT_MYCTO

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site64-66substrate
Binding site77substrate
Binding site81-83substrate
Binding site91substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • Ordered locus names
      MT2771

Organism names

Accessions

  • Primary accession
    P9WNS4
  • Secondary accessions
    • L0TAD4
    • O07199
    • P0A552

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004270761-154Deoxyuridine 5'-triphosphate nucleotidohydrolase

Interaction

Subunit

Homotrimer.

Structure

Family & Domains

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    154
  • Mass (Da)
    15,803
  • Last updated
    2014-04-16 v1
  • Checksum
    836D5E6420EF455B
MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000516
EMBL· GenBank· DDBJ
AAK47086.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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