UniProtKB - P9WNR1 (ECCB4_MYCTU)
Protein
ESX-4 secretion system ATPase EccB4
Gene
eccB4
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
An ATPase (By similarity).By similarity
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- hydrolase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7727-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: ESX-4 secretion system ATPase EccB4 (EC:3.6.-.-Curated)Alternative name(s): ESX conserved component B4 Type VII secretion system protein EccB4 Short name: T7SS protein EccB4 |
Gene namesi | Name:eccB4 Ordered Locus Names:Rv3450c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv3450c |
Subcellular locationi
- Cell membrane Curated; Single-pass membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 44 – 64 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- integral component of membrane Source: UniProtKB-KW
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393231 | 1 – 470 | ESX-4 secretion system ATPase EccB4Add BLAST | 470 |
Proteomic databases
PaxDbi | P9WNR1 |
PRIDEi | P9WNR1 |
Interactioni
Subunit structurei
Part of the ESX-4 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components.
By similarityProtein-protein interaction databases
STRINGi | 83332.Rv3450c |
Family & Domainsi
Sequence similaritiesi
Belongs to the EccB family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4108T50 Bacteria ENOG4111H3F LUCA |
OMAi | VRRMEHA |
PhylomeDBi | P9WNR1 |
Family and domain databases
Gene3Di | 2.40.50.910, 1 hit |
InterProi | View protein in InterPro IPR007795 T7SS_EccB IPR042485 T7SS_EccB_R3 |
PANTHERi | PTHR40765 PTHR40765, 1 hit |
Pfami | View protein in Pfam PF05108 T7SS_ESX1_EccB, 1 hit |
TIGRFAMsi | TIGR03919 T7SS_EccB, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WNR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPSPATTWLH VSGYRFLLRR IECALLFGDV CAATGALRAR TTSLALGCVL
60 70 80 90 100
AIVAAMGCAF VALLRPQSAL GQAPIVMGRE SGALYVRVDD VWHPVLNLAS
110 120 130 140 150
ARLIAATNAN PQPVSESELG HTKRGPLLGI PGAPQLLDQP LAGAESAWAI
160 170 180 190 200
CDSDNGGSTT VVVGPAEDSS AQVLTAEQMI LVATESGSPT YLLYGGRRAV
210 220 230 240 250
VDLADPAVVW ALRLQGRVPH VVAQSLLNAV PEAPRITAPR IRGGGRASVG
260 270 280 290 300
LPGFLVGGVV RITRASGDEY YVVLEDGVQR IGQVAADLLR FGDSQGSVNV
310 320 330 340 350
PTVAPDVIRV APIVNTLPVS AFPDRPPTPV DGSPGRAVTT LCVTWTPAQP
360 370 380 390 400
GAARVAFLAG SGPPVPLGGV PVTLAQADGR GPALDAVYLP PGRSAYVAAR
410 420 430 440 450
SLSGGGTGTR YLVTDTGVRF AIHDDDVAHD LGLPTAAIPA PWPVLATLPS
460 470
GPELSRANAS VARDTVAPGP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46272.1 |
PIRi | G70564 |
RefSeqi | NP_217967.1, NC_000962.3 WP_003418333.1, NZ_NVQJ01000065.1 |
Genome annotation databases
EnsemblBacteriai | CCP46272; CCP46272; Rv3450c |
GeneIDi | 887619 |
KEGGi | mtu:Rv3450c mtv:RVBD_3450c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP46272.1 |
PIRi | G70564 |
RefSeqi | NP_217967.1, NC_000962.3 WP_003418333.1, NZ_NVQJ01000065.1 |
3D structure databases
SMRi | P9WNR1 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv3450c |
Proteomic databases
PaxDbi | P9WNR1 |
PRIDEi | P9WNR1 |
Genome annotation databases
EnsemblBacteriai | CCP46272; CCP46272; Rv3450c |
GeneIDi | 887619 |
KEGGi | mtu:Rv3450c mtv:RVBD_3450c |
Organism-specific databases
TubercuListi | Rv3450c |
Phylogenomic databases
eggNOGi | ENOG4108T50 Bacteria ENOG4111H3F LUCA |
OMAi | VRRMEHA |
PhylomeDBi | P9WNR1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7727-MONOMER |
Family and domain databases
Gene3Di | 2.40.50.910, 1 hit |
InterProi | View protein in InterPro IPR007795 T7SS_EccB IPR042485 T7SS_EccB_R3 |
PANTHERi | PTHR40765 PTHR40765, 1 hit |
Pfami | View protein in Pfam PF05108 T7SS_ESX1_EccB, 1 hit |
TIGRFAMsi | TIGR03919 T7SS_EccB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ECCB4_MYCTU | |
Accessioni | P9WNR1Primary (citable) accession number: P9WNR1 Secondary accession number(s): L0TE61, O06317, Q7D5I7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names