UniProtKB - P9WNM1 (EFTS_MYCTU)
Protein
Elongation factor Ts
Gene
tsf
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity).By similarity
Miscellaneous
Was identified as a high-confidence drug target.
GO - Molecular functioni
- translation elongation factor activity Source: GO_Central
Keywordsi
Molecular function | Elongation factor |
Biological process | Protein biosynthesis |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7141-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Elongation factor TsShort name: EF-Ts |
Gene namesi | Name:tsf Ordered Locus Names:Rv2889c ORF Names:MTCY274.20c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2889c |
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cell wall Source: MTBBASE
- cytosol Source: MTBBASE
- plasma membrane Source: MTBBASE
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161160 | 1 – 271 | Elongation factor TsAdd BLAST | 271 |
Proteomic databases
PaxDbi | P9WNM1 |
PRIDEi | P9WNM1 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 76 – 79 | Involved in Mg(2+) ion dislocation from EF-TuBy similarity | 4 |
Sequence similaritiesi
Belongs to the EF-Ts family.Curated
Phylogenomic databases
eggNOGi | ENOG4105CU7 Bacteria COG0264 LUCA |
KOi | K02357 |
OMAi | DAGMMDC |
PhylomeDBi | P9WNM1 |
Family and domain databases
Gene3Di | 3.30.479.20, 2 hits |
HAMAPi | MF_00050 EF_Ts, 1 hit |
InterProi | View protein in InterPro IPR036402 EF-Ts_dimer_sf IPR001816 Transl_elong_EFTs/EF1B IPR014039 Transl_elong_EFTs/EF1B_dimer IPR018101 Transl_elong_Ts_CS IPR009060 UBA-like_sf |
PANTHERi | PTHR11741 PTHR11741, 1 hit |
Pfami | View protein in Pfam PF00889 EF_TS, 1 hit |
SUPFAMi | SSF46934 SSF46934, 1 hit SSF54713 SSF54713, 2 hits |
TIGRFAMsi | TIGR00116 tsf, 1 hit |
PROSITEi | View protein in PROSITE PS01126 EF_TS_1, 1 hit PS01127 EF_TS_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WNM1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANFTAADVK RLRELTGAGM LACKNALAET DGDFDKAVEA LRIKGAKDVG
60 70 80 90 100
KRAERATAEG LVAAKDGALI ELNCETDFVA KNAEFQTLAD QVVAAAAAAK
110 120 130 140 150
PADVDALKGA SIGDKTVEQA IAELSAKIGE KLELRRVAIF DGTVEAYLHR
160 170 180 190 200
RSADLPPAVG VLVEYRGDDA AAAHAVALQI AALRARYLSR DDVPEDIVAS
210 220 230 240 250
ERRIAEETAR AEGKPEQALP KIVEGRLNGF FKDAVLLEQA SVSDNKKTVK
260 270
ALLDVAGVTV TRFVRFEVGQ A
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45691.1 |
PIRi | D70925 |
RefSeqi | NP_217405.1, NC_000962.3 WP_003899527.1, NZ_NVQJ01000006.1 |
Genome annotation databases
EnsemblBacteriai | CCP45691; CCP45691; Rv2889c |
GeneIDi | 888187 |
KEGGi | mtu:Rv2889c mtv:RVBD_2889c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP45691.1 |
PIRi | D70925 |
RefSeqi | NP_217405.1, NC_000962.3 WP_003899527.1, NZ_NVQJ01000006.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv2889c |
Proteomic databases
PaxDbi | P9WNM1 |
PRIDEi | P9WNM1 |
Genome annotation databases
EnsemblBacteriai | CCP45691; CCP45691; Rv2889c |
GeneIDi | 888187 |
KEGGi | mtu:Rv2889c mtv:RVBD_2889c |
Organism-specific databases
TubercuListi | Rv2889c |
Phylogenomic databases
eggNOGi | ENOG4105CU7 Bacteria COG0264 LUCA |
KOi | K02357 |
OMAi | DAGMMDC |
PhylomeDBi | P9WNM1 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-7141-MONOMER |
Family and domain databases
Gene3Di | 3.30.479.20, 2 hits |
HAMAPi | MF_00050 EF_Ts, 1 hit |
InterProi | View protein in InterPro IPR036402 EF-Ts_dimer_sf IPR001816 Transl_elong_EFTs/EF1B IPR014039 Transl_elong_EFTs/EF1B_dimer IPR018101 Transl_elong_Ts_CS IPR009060 UBA-like_sf |
PANTHERi | PTHR11741 PTHR11741, 1 hit |
Pfami | View protein in Pfam PF00889 EF_TS, 1 hit |
SUPFAMi | SSF46934 SSF46934, 1 hit SSF54713 SSF54713, 2 hits |
TIGRFAMsi | TIGR00116 tsf, 1 hit |
PROSITEi | View protein in PROSITE PS01126 EF_TS_1, 1 hit PS01127 EF_TS_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EFTS_MYCTU | |
Accessioni | P9WNM1Primary (citable) accession number: P9WNM1 Secondary accession number(s): L0TB62, Q10788 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | September 18, 2019 | |
This is version 28 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names