Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 35 (16 Oct 2019)
Sequence version 1 (16 Apr 2014)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Probable arabinosyltransferase A

Gene

embA

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.

Miscellaneous

This is one of the target of the anti-tuberculosis drug ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB]. EMB is a first-line drug used to treat tuberculosis. EMB inhibits the transfer of arabinogalactan into the cell wall.
Was identified as a high-confidence drug target.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAntibiotic resistance, Cell wall biogenesis/degradation

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-8090-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable arabinosyltransferase A (EC:2.4.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:embA
Ordered Locus Names:Rv3794
ORF Names:MTCY13D12.28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv3794

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Transmembranei205 – 224HelicalSequence analysisAdd BLAST20
Transmembranei247 – 269HelicalSequence analysisAdd BLAST23
Transmembranei322 – 344HelicalSequence analysisAdd BLAST23
Transmembranei356 – 375HelicalSequence analysisAdd BLAST20
Transmembranei408 – 430HelicalSequence analysisAdd BLAST23
Transmembranei451 – 470HelicalSequence analysisAdd BLAST20
Transmembranei519 – 536HelicalSequence analysisAdd BLAST18
Transmembranei543 – 565HelicalSequence analysisAdd BLAST23
Transmembranei575 – 597HelicalSequence analysisAdd BLAST23
Transmembranei604 – 626HelicalSequence analysisAdd BLAST23
Transmembranei641 – 663HelicalSequence analysisAdd BLAST23
Transmembranei684 – 706HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1877

Drug and drug target database

More...
DrugBanki
DB00330 Ethambutol

DrugCentral

More...
DrugCentrali
P9WNL9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205641 – 1094Probable arabinosyltransferase AAdd BLAST1094

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WNL9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Positively regulated by the transcriptional regulatory protein EmbR.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv3794

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P9WNL9

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WNL9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the emb family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4108NUW Bacteria
ENOG410Z8I9 LUCA

KEGG Orthology (KO)

More...
KOi
K11385

Identification of Orthologs from Complete Genome Data

More...
OMAi
GWLHFRM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P9WNL9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.610, 1 hit
2.60.120.940, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032731 Arabino_trans_C
IPR042486 Arabino_trans_C_2
IPR007680 Arabino_trans_central
IPR040920 Arabino_trans_N
IPR027451 EmbABC_dom1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14896 Arabino_trans_C, 1 hit
PF17689 Arabino_trans_N, 1 hit
PF04602 Arabinose_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WNL9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPHDGNERSH RIARLAAVVS GIAGLLLCGI VPLLPVNQTT ATIFWPQGST
60 70 80 90 100
ADGNITQITA PLVSGAPRAL DISIPCSAIA TLPANGGLVL STLPAGGVDT
110 120 130 140 150
GKAGLFVRAN QDTVVVAFRD SVAAVAARST IAAGGCSALH IWADTGGAGA
160 170 180 190 200
DFMGIPGGAG TLPPEKKPQV GGIFTDLKVG AQPGLSARVD IDTRFITTPG
210 220 230 240 250
ALKKAVMLLG VLAVLVAMVG LAALDRLSRG RTLRDWLTRY RPRVRVGFAS
260 270 280 290 300
RLADAAVIAT LLLWHVIGAT SSDDGYLLTV ARVAPKAGYV ANYYRYFGTT
310 320 330 340 350
EAPFDWYTSV LAQLAAVSTA GVWMRLPATL AGIACWLIVS RFVLRRLGPG
360 370 380 390 400
PGGLASNRVA VFTAGAVFLS AWLPFNNGLR PEPLIALGVL VTWVLVERSI
410 420 430 440 450
ALGRLAPAAV AIIVATLTAT LAPQGLIALA PLLTGARAIA QRIRRRRATD
460 470 480 490 500
GLLAPLAVLA AALSLITVVV FRDQTLATVA ESARIKYKVG PTIAWYQDFL
510 520 530 540 550
RYYFLTVESN VEGSMSRRFA VLVLLFCLFG VLFVLLRRGR VAGLASGPAW
560 570 580 590 600
RLIGTTAVGL LLLTFTPTKW AVQFGAFAGL AGVLGAVTAF TFARIGLHSR
610 620 630 640 650
RNLTLYVTAL LFVLAWATSG INGWFYVGNY GVPWYDIQPV IASHPVTSMF
660 670 680 690 700
LTLSILTGLL AAWYHFRMDY AGHTEVKDNR RNRILASTPL LVVAVIMVAG
710 720 730 740 750
EVGSMAKAAV FRYPLYTTAK ANLTALSTGL SSCAMADDVL AEPDPNAGML
760 770 780 790 800
QPVPGQAFGP DGPLGGISPV GFKPEGVGED LKSDPVVSKP GLVNSDASPN
810 820 830 840 850
KPNAAITDSA GTAGGKGPVG INGSHAALPF GLDPARTPVM GSYGENNLAA
860 870 880 890 900
TATSAWYQLP PRSPDRPLVV VSAAGAIWSY KEDGDFIYGQ SLKLQWGVTG
910 920 930 940 950
PDGRIQPLGQ VFPIDIGPQP AWRNLRFPLA WAPPEADVAR IVAYDPNLSP
960 970 980 990 1000
EQWFAFTPPR VPVLESLQRL IGSATPVLMD IATAANFPCQ RPFSEHLGIA
1010 1020 1030 1040 1050
ELPQYRILPD HKQTAASSNL WQSSSTGGPF LFTQALLRTS TIATYLRGDW
1060 1070 1080 1090
YRDWGSVEQY HRLVPADQAP DAVVEEGVIT VPGWGRPGPI RALP
Length:1,094
Mass (Da):115,724
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i11EEA34999633EEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116Missing in AAC45280 (PubMed:9142129).Curated1
Sequence conflicti899 – 900TG → HR in AAC45280 (PubMed:9142129).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti201A → T Resistance to EMB. 1 Publication1
Natural varianti321G → S Resistance to EMB. 1 Publication1
Natural varianti350G → D Resistance to EMB. 1 Publication1
Natural varianti462A → V Resistance to EMB. 1 Publication1
Natural varianti833D → A Resistance to EMB. 1 Publication1
Natural varianti913P → S Resistance to EMB. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U68480 Genomic DNA Translation: AAC45280.1
AL123456 Genomic DNA Translation: CCP46623.1

Protein sequence database of the Protein Information Resource

More...
PIRi
F70697

NCBI Reference Sequences

More...
RefSeqi
NP_218311.1, NC_000962.3
WP_003899696.1, NZ_NVQJ01000009.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP46623; CCP46623; Rv3794

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
886123

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv3794
mtv:RVBD_3794

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U68480 Genomic DNA Translation: AAC45280.1
AL123456 Genomic DNA Translation: CCP46623.1
PIRiF70697
RefSeqiNP_218311.1, NC_000962.3
WP_003899696.1, NZ_NVQJ01000009.1

3D structure databases

SMRiP9WNL9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv3794

Chemistry databases

BindingDBiP9WNL9
ChEMBLiCHEMBL1877
DrugBankiDB00330 Ethambutol
DrugCentraliP9WNL9

Proteomic databases

PaxDbiP9WNL9

Genome annotation databases

EnsemblBacteriaiCCP46623; CCP46623; Rv3794
GeneIDi886123
KEGGimtu:Rv3794
mtv:RVBD_3794

Organism-specific databases

TubercuListiRv3794

Phylogenomic databases

eggNOGiENOG4108NUW Bacteria
ENOG410Z8I9 LUCA
KOiK11385
OMAiGWLHFRM
PhylomeDBiP9WNL9

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-8090-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P9WNL9

Family and domain databases

Gene3Di2.60.120.610, 1 hit
2.60.120.940, 1 hit
InterProiView protein in InterPro
IPR032731 Arabino_trans_C
IPR042486 Arabino_trans_C_2
IPR007680 Arabino_trans_central
IPR040920 Arabino_trans_N
IPR027451 EmbABC_dom1
PfamiView protein in Pfam
PF14896 Arabino_trans_C, 1 hit
PF17689 Arabino_trans_N, 1 hit
PF04602 Arabinose_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMBA_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WNL9
Secondary accession number(s): L0TDK4
, P0A560, P72029, P72060
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: October 16, 2019
This is version 35 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again