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Entry version 25 (18 Sep 2019)
Sequence version 1 (16 Apr 2014)
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Protein

ESX-5 secretion system protein EccC5

Gene

eccC5

Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the ESX-5 specialized secretion system, which is responsible for the secretion of EsxN and a number of PE_PGRS and PPE proteins, including PPE41.3 Publications

Miscellaneous

Part of the eccB5-eccC5 operon, which is essential for in vitro growth.1 Publication

Caution

Was originally thought to be the product of two separate ORFs, eccCa5 and eccCb5.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi499 – 506ATPPROSITE-ProRule annotation8
Nucleotide bindingi876 – 883ATPPROSITE-ProRule annotation8
Nucleotide bindingi1178 – 1185ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MTBH37RV:G185E-5979-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ESX-5 secretion system protein EccC5Curated
Alternative name(s):
ESX conserved component C51 Publication
Type VII secretion system protein EccC5Curated
Short name:
T7SS protein EccC5Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eccC51 Publication
Ordered Locus Names:Rv1783
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83332 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

Organism-specific databases

Mycobacterium tuberculosis strain H37Rv genome database

More...
TubercuListi
Rv1783

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Transmembranei65 – 85HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mutants are defective in the secretion of EsxN, PPE41 and PE_PGRS proteins.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003934331 – 1391ESX-5 secretion system protein EccC5Add BLAST1391

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P9WNA5

PRoteomics IDEntifications database

More...
PRIDEi
P9WNA5

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of the ESX-5 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components. The ESX-5 membrane complex is composed of EccB5, EccC5, EccD5 and EccE5.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
83332.Rv1783

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P9WNA5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini476 – 678FtsK 1PROSITE-ProRule annotationAdd BLAST203
Domaini858 – 1052FtsK 2PROSITE-ProRule annotationAdd BLAST195
Domaini1161 – 1354FtsK 3PROSITE-ProRule annotationAdd BLAST194

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi76 – 113Met-richPROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105EC2 Bacteria
COG1674 LUCA

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR023836 EccCa-like_Actinobacteria
IPR023837 EccCb-like_Actinobacteria
IPR002543 FtsK_dom
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01580 FtsK_SpoIIIE, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03924 T7SS_EccC_a, 1 hit
TIGR03925 T7SS_EccC_b, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50901 FTSK, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P9WNA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRGFARPTP EKPPVIKPEN IVLSTPLSIP PPEGKPWWLI VVGVVVVGLL
60 70 80 90 100
GGMVAMVFAS GSHVFGGIGS IFPLFMMVGI MMMMFRGMGG GQQQMSRPKL
110 120 130 140 150
DAMRAQFMLM LDMLRETAQE SADSMDANYR WFHPAPNTLA AAVGSPRMWE
160 170 180 190 200
RKPDGKDLNF GVVRVGVGMT RPEVTWGEPQ NMPTDIELEP VTGKALQEFG
210 220 230 240 250
RYQSVVYNLP KMVSLLVEPW YALVGEREQV LGLMRAIICQ LAFSHGPDHV
260 270 280 290 300
QMIVVSSDLD QWDWVKWLPH FGDSRRHDAA GNARMVYTSV REFAAEQAEL
310 320 330 340 350
FAGRGSFTPR HASSSAQTPT PHTVIIADVD DPQWEYVISA EGVDGVTFFD
360 370 380 390 400
LTGSSMWTDI PERKLQFDKT GVIEALPRDR DTWMVIDDKA WFFALTDQVS
410 420 430 440 450
IAEAEEFAQK LAQWRLAEAY EEIGQRVAHI GARDILSYYG IDDPGNIDFD
460 470 480 490 500
SLWASRTDTM GRSRLRAPFG NRSDNGELLF LDMKSLDEGG DGPHGVMSGT
510 520 530 540 550
TGSGKSTLVR TVIESLMLSH PPEELQFVLA DLKGGSAVKP FAGVPHVSRI
560 570 580 590 600
ITDLEEDQAL MERFLDALWG EIARRKAICD SAGVDDAKEY NSVRARMRAR
610 620 630 640 650
GQDMAPLPML VVVIDEFYEW FRIMPTAVDV LDSIGRQGRA YWIHLMMASQ
660 670 680 690 700
TIESRAEKLM ENMGYRLVLK ARTAGAAQAA GVPNAVNLPA QAGLGYFRKS
710 720 730 740 750
LEDIIRFQAE FLWRDYFQPG VSIDGEEAPA LVHSIDYIRP QLFTNSFTPL
760 770 780 790 800
EVSVGGPDIE PVVAQPNGEV LESDDIEGGE DEDEEGVRTP KVGTVIIDQL
810 820 830 840 850
RKIKFEPYRL WQPPLTQPVA IDDLVNRFLG RPWHKEYGSA CNLVFPIGII
860 870 880 890 900
DRPYKHDQPP WTVDTSGPGA NVLILGAGGS GKTTALQTLI CSAALTHTPQ
910 920 930 940 950
QVQFYCLAYS STALTTVSRI PHVGEVAGPT DPYGVRRTVA ELLALVRERK
960 970 980 990 1000
RSFLECGIAS MEMFRRRKFG GEAGPVPDDG FGDVYLVIDN YRALAEENEV
1010 1020 1030 1040 1050
LIEQVNVIIN QGPSFGVHVV VTADRESELR PPVRSGFGSR IELRLAAVED
1060 1070 1080 1090 1100
AKLVRSRFAK DVPVKPGRGM VAVNYVRLDS DPQAGLHTLV ARPALGSTPD
1110 1120 1130 1140 1150
NVFECDSVVA AVSRLTSAQA PPVRRLPARF GVEQVRELAS RDTRQGVGAG
1160 1170 1180 1190 1200
GIAWAISELD LAPVYLNFAE NSHLMVTGRR ECGRTTTLAT IMSEIGRLYA
1210 1220 1230 1240 1250
PGASSAPPPA PGRPSAQVWL VDPRRQLLTA LGSDYVERFA YNLDGVVAMM
1260 1270 1280 1290 1300
GELAAALAGR EPPPGLSAEE LLSRSWWSGP EIFLIVDDIQ QLPPGFDSPL
1310 1320 1330 1340 1350
HKAVPFVNRA ADVGLHVIVT RTFGGWSSAG SDPMLRALHQ ANAPLLVMDA
1360 1370 1380 1390
DPDEGFIRGK MKGGPLPRGR GLLMAEDTGV FVQVAATEVR R
Length:1,391
Mass (Da):152,740
Last modified:April 16, 2014 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDC7B8D899AD21820
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44550.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A70929
B70929

NCBI Reference Sequences

More...
RefSeqi
WP_003408799.1, NZ_NVQJ01000037.1
YP_007410461.1, NC_000962.3

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CCP44550; CCP44550; Rv1783

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
885898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mtu:Rv1783
mtv:RVBD_1783

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL123456 Genomic DNA Translation: CCP44550.1
PIRiA70929
B70929
RefSeqiWP_003408799.1, NZ_NVQJ01000037.1
YP_007410461.1, NC_000962.3

3D structure databases

SMRiP9WNA5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi83332.Rv1783

Proteomic databases

PaxDbiP9WNA5
PRIDEiP9WNA5

Genome annotation databases

EnsemblBacteriaiCCP44550; CCP44550; Rv1783
GeneIDi885898
KEGGimtu:Rv1783
mtv:RVBD_1783

Organism-specific databases

TubercuListiRv1783

Phylogenomic databases

eggNOGiENOG4105EC2 Bacteria
COG1674 LUCA

Enzyme and pathway databases

BioCyciMTBH37RV:G185E-5979-MONOMER

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR023836 EccCa-like_Actinobacteria
IPR023837 EccCb-like_Actinobacteria
IPR002543 FtsK_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01580 FtsK_SpoIIIE, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 3 hits
SUPFAMiSSF52540 SSF52540, 2 hits
TIGRFAMsiTIGR03924 T7SS_EccC_a, 1 hit
TIGR03925 T7SS_EccC_b, 1 hit
PROSITEiView protein in PROSITE
PS50901 FTSK, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiECCC5_MYCTU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P9WNA5
Secondary accession number(s): L0T992
, O53934, O53935, Q8VJW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2014
Last sequence update: April 16, 2014
Last modified: September 18, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
    Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names
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