ID FTSW_MYCTU Reviewed; 524 AA. AC P9WN97; L0T901; O06223; P63762; DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot. DT 16-APR-2014, sequence version 1. DT 07-JAN-2015, entry version 8. DE RecName: Full=Putative lipid II flippase FtsW; DE AltName: Full=Cell division protein FtsW; GN Name=ftsW; OrderedLocusNames=Rv2154c; ORFNames=MTCY270.14; OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. OX NCBI_TaxID=83332; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 25618 / H37Rv; RX PubMed=9634230; DOI=10.1038/31159; RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the RT complete genome sequence."; RL Nature 393:537-544(1998). RN [2] RP INTERACTION WITH FTSZ, AND DOMAIN. RC STRAIN=ATCC 25618 / H37Rv; RX PubMed=12101218; DOI=10.1074/jbc.M203847200; RA Datta P., Dasgupta A., Bhakta S., Basu J.; RT "Interaction between FtsZ and FtsW of Mycobacterium tuberculosis."; RL J. Biol. Chem. 277:24983-24987(2002). RN [3] RP SUBUNIT, INTERACTION WITH PBPB, SUBCELLULAR LOCATION, TOPOLOGY, AND RP DOMAIN. RX PubMed=17427288; DOI=10.1111/j.1365-2958.2006.05491.x; RA Datta P., Dasgupta A., Singh A.K., Mukherjee P., Kundu M., Basu J.; RT "Interaction between FtsW and penicillin-binding protein 3 (PBP3) RT directs PBP3 to mid-cell, controls cell septation and mediates the RT formation of a trimeric complex involving FtsZ, FtsW and PBP3 in RT mycobacteria."; RL Mol. Microbiol. 62:1655-1673(2006). CC -!- FUNCTION: Essential cell division protein. Transports lipid-linked CC peptidoglycan precursors from the inner to the outer leaflet of CC the cytoplasmic membrane (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Forms a complex with FtsZ and PbpB (PBP3, FtsI). CC {ECO:0000269|PubMed:17427288}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17427288}; CC Multi-pass membrane protein {ECO:0000269|PubMed:17427288}. CC Note=Localizes to the division septum. {ECO:0000250}. CC -!- DOMAIN: Interacts with FtsZ via its C-terminal region, and with CC PbpB via two extracytoplasmic loops. {ECO:0000269|PubMed:12101218, CC ECO:0000269|PubMed:17427288}. CC -!- SIMILARITY: Belongs to the SEDS family. FtsW subfamily. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL123456; CCP44930.1; -; Genomic_DNA. DR PIR; F70579; F70579. DR RefSeq; NP_216670.1; NC_000962.3. DR RefSeq; YP_006515573.1; NC_018143.2. DR ProteinModelPortal; P9WN97; -. DR GeneID; 13316965; -. DR GeneID; 887916; -. DR KEGG; mtu:Rv2154c; -. DR KEGG; mtv:RVBD_2154c; -. DR TubercuList; Rv2154c; -. DR KO; K03588; -. DR OMA; RAKWSYL; -. DR PhylomeDB; P9WN97; -. DR Proteomes; UP000001584; Chromosome. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW. DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0040007; P:growth; IMP:MTBBASE. DR GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:UniProtKB-KW. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW. DR GO; GO:0006810; P:transport; IEA:UniProtKB-KW. DR InterPro; IPR018365; Cell_cycle_FtsW-rel_CS. DR InterPro; IPR001182; Cell_cycle_FtsW/RodA. DR InterPro; IPR013437; Cell_div_FtsW. DR PANTHER; PTHR30474; PTHR30474; 1. DR Pfam; PF01098; FTSW_RODA_SPOVE; 1. DR TIGRFAMs; TIGR02614; ftsW; 1. DR PROSITE; PS00428; FTSW_RODA_SPOVE; 1. PE 1: Evidence at protein level; KW Cell cycle; Cell division; Cell membrane; Cell shape; KW Cell wall biogenesis/degradation; Complete proteome; Membrane; KW Peptidoglycan synthesis; Reference proteome; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1 524 Putative lipid II flippase FtsW. FT /FTId=PRO_0000062725. FT TOPO_DOM 1 55 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 56 76 Helical. {ECO:0000255}. FT TOPO_DOM 77 89 Extracellular. {ECO:0000255}. FT TRANSMEM 90 110 Helical. {ECO:0000255}. FT TOPO_DOM 111 121 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 122 142 Helical. {ECO:0000255}. FT TOPO_DOM 143 151 Extracellular. {ECO:0000255}. FT TRANSMEM 152 172 Helical. {ECO:0000255}. FT TOPO_DOM 173 191 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 192 212 Helical. {ECO:0000255}. FT TRANSMEM 213 233 Helical. {ECO:0000255}. FT TOPO_DOM 234 234 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 235 255 Helical. {ECO:0000255}. FT TOPO_DOM 256 311 Extracellular. {ECO:0000255}. FT TRANSMEM 312 332 Helical. {ECO:0000255}. FT TOPO_DOM 333 350 Cytoplasmic. {ECO:0000255}. FT TRANSMEM 351 373 Helical. {ECO:0000255}. FT TOPO_DOM 374 388 Extracellular. {ECO:0000255}. FT TRANSMEM 389 409 Helical. {ECO:0000255}. FT TOPO_DOM 410 524 Cytoplasmic. {ECO:0000255}. SQ SEQUENCE 524 AA; 56337 MW; C98052A346739C7C CRC64; MLTRLLRRGT SDTDGSQTRG AEPVEGQRTG PEEASNPGSA RPRTRFGAWL GRPMTSFHLI IAVAALLTTL GLIMVLSASA VRSYDDDGSA WVIFGKQVLW TLVGLIGGYV CLRMSVRFMR RIAFSGFAIT IVMLVLVLVP GIGKEANGSR GWFVVAGFSM QPSELAKMAF AIWGAHLLAA RRMERASLRE MLIPLVPAAV VALALIVAQP DLGQTVSMGI ILLGLLWYAG LPLRVFLSSL AAVVVSAAIL AVSAGYRSDR VRSWLNPEND PQDSGYQARQ AKFALAQGGI FGDGLGQGVA KWNYLPNAHN DFIFAIIGEE LGLVGALGLL GLFGLFAYTG MRIASRSADP FLRLLTATTT LWVLGQAFIN IGYVIGLLPV TGLQLPLISA GGTSTAATLS LIGIIANAAR HEPEAVAALR AGRDDKVNRL LRLPLPEPYL PPRLEAFRDR KRANPQPAQT QPARKTPRTA PGQPARQMGL PPRPGSPRTA DPPVRRSVHH GAGQRYAGQR RTRRVRALEG QRYG //