UniProtKB - P9WN87 (FURA_MYCTU)
Protein
Transcriptional regulator FurA
Gene
furA
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Represses transcription of the catalase-peroxidase gene katG and its own transcription by binding to the promoter region in a redox-dependent manner.2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 34 | ZincBy similarity | 1 | |
Metal bindingi | 82 | ZincBy similarity | 1 | |
Metal bindingi | 87 | IronBy similarity | 1 | |
Metal bindingi | 89 | IronBy similarity | 1 | |
Metal bindingi | 91 | ZincBy similarity | 1 | |
Metal bindingi | 94 | ZincBy similarity | 1 | |
Metal bindingi | 97 | ZincBy similarity | 1 | |
Metal bindingi | 102 | ZincBy similarity | 1 | |
Metal bindingi | 109 | IronBy similarity | 1 |
GO - Molecular functioni
- DNA binding Source: GO_Central
- DNA-binding transcription factor activity Source: MTBBASE
- transcription regulatory region DNA binding Source: GO_Central
- zinc ion binding Source: GO_Central
GO - Biological processi
- negative regulation of transcription, DNA-templated Source: GO_Central
- regulation of secondary metabolite biosynthetic process Source: GO_Central
- regulation of transcription, DNA-templated Source: MTBBASE
- response to iron ion Source: MTBBASE
- response to oxidative stress Source: MTBBASE
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Iron, Metal-binding, Zinc |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6106-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional regulator FurA |
Gene namesi | Name:furA Synonyms:fur Ordered Locus Names:Rv1909c ORF Names:MTCY180.09 |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1909c |
Subcellular locationi
- Cytoplasm By similarity
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000095562 | 1 – 147 | Transcriptional regulator FurAAdd BLAST | 147 |
Proteomic databases
PaxDbi | P9WN87 |
Expressioni
Inductioni
Negatively autoregulated.2 Publications
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
STRINGi | 83332.Rv1909c |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 85 | DNA-bindingBy similarityAdd BLAST | 85 | |
Regioni | 86 – 147 | DimerizationBy similarityAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 89 – 91 | His-rich | 3 |
Sequence similaritiesi
Belongs to the Fur family.Curated
Phylogenomic databases
eggNOGi | ENOG4107YTX Bacteria COG0735 LUCA |
KOi | K22297 |
OMAi | DHPHADT |
Family and domain databases
CDDi | cd07153 Fur_like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR002481 FUR IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
PANTHERi | PTHR33202 PTHR33202, 1 hit |
Pfami | View protein in Pfam PF01475 FUR, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WN87-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSIPDYAEQ LRTADLRVTR PRVAVLEAVN AHPHADTETI FGAVRFALPD
60 70 80 90 100
VSRQAVYDVL HALTAAGLVR KIQPSGSVAR YESRVGDNHH HIVCRSCGVI
110 120 130 140
ADVDCAVGEA PCLTASDHNG FLLDEAEVIY WGLCPDCSIS DTSRSHP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002194 Genomic DNA Translation: AAB63370.1 AF012630 Genomic DNA Translation: AAB66826.1 AL123456 Genomic DNA Translation: CCP44676.1 |
PIRi | B70519 |
RefSeqi | NP_216425.2, NC_000962.3 WP_003899076.1, NZ_NVQJ01000034.1 |
Genome annotation databases
EnsemblBacteriai | CCP44676; CCP44676; Rv1909c |
GeneIDi | 885400 |
KEGGi | mtu:Rv1909c mtv:RVBD_1909c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF002194 Genomic DNA Translation: AAB63370.1 AF012630 Genomic DNA Translation: AAB66826.1 AL123456 Genomic DNA Translation: CCP44676.1 |
PIRi | B70519 |
RefSeqi | NP_216425.2, NC_000962.3 WP_003899076.1, NZ_NVQJ01000034.1 |
3D structure databases
SMRi | P9WN87 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1909c |
Proteomic databases
PaxDbi | P9WN87 |
Genome annotation databases
EnsemblBacteriai | CCP44676; CCP44676; Rv1909c |
GeneIDi | 885400 |
KEGGi | mtu:Rv1909c mtv:RVBD_1909c |
Organism-specific databases
TubercuListi | Rv1909c |
Phylogenomic databases
eggNOGi | ENOG4107YTX Bacteria COG0735 LUCA |
KOi | K22297 |
OMAi | DHPHADT |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-6106-MONOMER |
Family and domain databases
CDDi | cd07153 Fur_like, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR002481 FUR IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf |
PANTHERi | PTHR33202 PTHR33202, 1 hit |
Pfami | View protein in Pfam PF01475 FUR, 1 hit |
SUPFAMi | SSF46785 SSF46785, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FURA_MYCTU | |
Accessioni | P9WN87Primary (citable) accession number: P9WN87 Secondary accession number(s): L0T9L6 P0A582 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 32 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names