UniProtKB - P9WN09 (RNTF_MYCTU)
Protein
PGL/p-HBAD biosynthesis rhamnosyltransferase
Gene
Rv2962c
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Catalyzes the transfer of the first rhamnosyl residue on p-hydroxybenzoic acid or phenolphthiocerol derivatives to form, after O-methylation at position 2 of the sugar unit, mono-O-methyl-glycosyl-p-hydroxybenzoic acid derivative (p-HBAD I) and 2-O-methyl-rhamnosyl-phenolphthiocerol dimycocerosate (also called mycoside B) during p-hydroxybenzoic acid derivatives (p-HBAD) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.1 Publication
Miscellaneous
Was identified as a high-confidence drug target.
GO - Molecular functioni
- transferase activity, transferring hexosyl groups Source: MTBBASE
- UDP-glycosyltransferase activity Source: InterPro
GO - Biological processi
- glycolipid biosynthetic process Source: MTBBASE
Keywordsi
Molecular function | Glycosyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | MetaCyc:G185E-7216-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Ordered Locus Names:Rv2962c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv2962c |
Subcellular locationi
GO - Cellular componenti
- intracellular membrane-bounded organelle Source: GO_Central
- plasma membrane Source: MTBBASE
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000313792 | 1 – 449 | PGL/p-HBAD biosynthesis rhamnosyltransferaseAdd BLAST | 449 |
Proteomic databases
PaxDbi | P9WN09 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyltransferase 28 family.Curated
Phylogenomic databases
eggNOGi | COG1819, Bacteria |
OMAi | HGMWAPA |
PhylomeDBi | P9WN09 |
Family and domain databases
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WN09-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRVSCVYATA SRWGGPPVAS EVRGDAAIST TPDAAPGLAA RRRRILFVAE
60 70 80 90 100
AVTLAHVVRP FALAQSLDPS RYEVHFACDP RYNQLLGPLP FRHHAIHTIP
110 120 130 140 150
SERFFGNLTQ GRFYAMRTLR KYVEADLRVL DEIAPDLVVG DLRISLSVSA
160 170 180 190 200
RLAGIPYIAI ANAYWSPYAQ RRFPLPDVIW TRLFGVRLVK LLYRLERPLL
210 220 230 240 250
FALQCMPLNW VRRRHGLSSL GWNLCRIFTD GDHTLYADVP ELMPTYDLPA
260 270 280 290 300
NHEYLGPVLW SPAGKPPTWW DSLPTDRPIV YATLGTSGGR NLLQLVLNAL
310 320 330 340 350
AELPVTVIAA TAGRSDLKTV PANAFVADYL PGEAAAARSA VVVCNGGSLT
360 370 380 390 400
TQQALVAGVP VIGVAGNLDQ HLNMEAVERA GAGVLLRTER LKSQRVAGAV
410 420 430 440
MQVISRSEYR QAAARLADAF GRDRVGFPQH VENALRLMPE NRPRTWLAS
Sequence cautioni
The sequence AAA50942 differs from that shown. Reason: Frameshift.Curated
The sequence AAA50943 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00024 Genomic DNA Translation: AAA50942.1 Frameshift. U00024 Genomic DNA Translation: AAA50943.1 Frameshift. AL123456 Genomic DNA Translation: CCP45766.1 |
PIRi | G70670 |
RefSeqi | NP_217478.1, NC_000962.3 WP_003414922.1, NZ_NVQJ01000015.1 |
Genome annotation databases
EnsemblBacteriai | CCP45766; CCP45766; Rv2962c |
GeneIDi | 23490795 887892 |
KEGGi | mtu:Rv2962c mtv:RVBD_2962c |
PATRICi | fig|83332.111.peg.3300 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00024 Genomic DNA Translation: AAA50942.1 Frameshift. U00024 Genomic DNA Translation: AAA50943.1 Frameshift. AL123456 Genomic DNA Translation: CCP45766.1 |
PIRi | G70670 |
RefSeqi | NP_217478.1, NC_000962.3 WP_003414922.1, NZ_NVQJ01000015.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 83332.Rv2962c |
Proteomic databases
PaxDbi | P9WN09 |
Genome annotation databases
EnsemblBacteriai | CCP45766; CCP45766; Rv2962c |
GeneIDi | 23490795 887892 |
KEGGi | mtu:Rv2962c mtv:RVBD_2962c |
PATRICi | fig|83332.111.peg.3300 |
Organism-specific databases
TubercuListi | Rv2962c |
Phylogenomic databases
eggNOGi | COG1819, Bacteria |
OMAi | HGMWAPA |
PhylomeDBi | P9WN09 |
Enzyme and pathway databases
BioCyci | MetaCyc:G185E-7216-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR002213, UDP_glucos_trans |
Pfami | View protein in Pfam PF00201, UDPGT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RNTF_MYCTU | |
Accessioni | P9WN09Primary (citable) accession number: P9WN09 Secondary accession number(s): L0TBE0 Q7D6C8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 7, 2020 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families