UniProtKB - P9WMR5 (DING_MYCTU)
Protein
Probable ATP-dependent helicase DinG homolog
Gene
dinG
Organism
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Status
Functioni
Probable helicase involved in DNA repair and perhaps also replication.By similarity
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 49 – 56 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | DNA damage, DNA recombination, DNA repair |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5508-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dinG Ordered Locus Names:Rv1329c ORF Names:MTCY130.14c |
Organismi | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Taxonomic identifieri | 83332 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
Organism-specific databases
TubercuListi | Rv1329c |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000102003 | 1 – 664 | Probable ATP-dependent helicase DinG homologAdd BLAST | 664 |
Proteomic databases
PaxDbi | P9WMR5 |
PRIDEi | P9WMR5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 290 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 277 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 246 – 249 | DEAH box | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG4105DVT Bacteria COG1199 LUCA |
KOi | K03722 |
OMAi | VVTNHAM |
PhylomeDBi | P9WMR5 |
Family and domain databases
InterProi | View protein in InterPro IPR006555 ATP-dep_Helicase_C IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3 IPR014001 Helicase_ATP-bd IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF13307 Helicase_C_2, 1 hit |
SMARTi | View protein in SMART SM00487 DEXDc, 1 hit SM00491 HELICc2, 1 hit |
SUPFAMi | SSF52540 SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51193 HELICASE_ATP_BIND_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WMR5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSESVSMSVP ELLAIAVAAL GGTRRRGQQE MAAAVAHAFE TGEHLVVQAG
60 70 80 90 100
TGTGKSLAYL VPAIIRALCD DAPVVVSTAT IALQRQLVDR DLPQLVDSLT
110 120 130 140 150
NALPRRPKFA LLKGRRNYLC LNKIHNSVTA SDHDDERPQE ELFDPVAVTA
160 170 180 190 200
LGRDVQRLTA WASTTVSGDR DDLKPGVGDR SWSQVSVSAR ECLGVARCPF
210 220 230 240 250
GSECFSERAR GAAGLADVVV TNHALLAIDA VAESAVLPEH RLLVVDEAHE
260 270 280 290 300
LADRVTSVAA AELTSATLGM AARRITRLVD PKVTQRLQAA SATFSSAIHD
310 320 330 340 350
ARPGRIDCLD DEMATYLSAL RDAASAARSA IDTGSDTTTA SVRAEAGAVL
360 370 380 390 400
TEISDTASRI LASFAPAIPD RSDVVWLEHE DNHESARAVL RVAPLSVAEL
410 420 430 440 450
LATQVFARAT TVLTSATLTI GGSFDAMATA WGLTADTPWR GLDVGSPFQH
460 470 480 490 500
AKSGILYVAA HLPPPGRDGS GSAEQLTEIA ELITAAGGRT LGLFSSMRAA
510 520 530 540 550
RAATEAMRER LSTPVLCQGD DSTSTLVEKF TADAATSLFG TLSLWQGVDV
560 570 580 590 600
PGPSLSLVLI DRIPFPRPDD PLLSARQRAV AARGGNGFMT VAASHAALLL
610 620 630 640 650
AQGSGRLLRR VTDRGVVAVL DSRMATARYG EFLRASLPPF WQTTNATQVR
660
AALRRLARAD AKAH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44087.1 |
PIRi | E70770 |
RefSeqi | NP_215845.1, NC_000962.3 WP_003898827.1, NZ_NVQJ01000031.1 |
Genome annotation databases
EnsemblBacteriai | CCP44087; CCP44087; Rv1329c |
GeneIDi | 886889 |
KEGGi | mtu:Rv1329c mtv:RVBD_1329c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL123456 Genomic DNA Translation: CCP44087.1 |
PIRi | E70770 |
RefSeqi | NP_215845.1, NC_000962.3 WP_003898827.1, NZ_NVQJ01000031.1 |
3D structure databases
SMRi | P9WMR5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 83332.Rv1329c |
Proteomic databases
PaxDbi | P9WMR5 |
PRIDEi | P9WMR5 |
Genome annotation databases
EnsemblBacteriai | CCP44087; CCP44087; Rv1329c |
GeneIDi | 886889 |
KEGGi | mtu:Rv1329c mtv:RVBD_1329c |
Organism-specific databases
TubercuListi | Rv1329c |
Phylogenomic databases
eggNOGi | ENOG4105DVT Bacteria COG1199 LUCA |
KOi | K03722 |
OMAi | VVTNHAM |
PhylomeDBi | P9WMR5 |
Enzyme and pathway databases
BioCyci | MTBH37RV:G185E-5508-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR006555 ATP-dep_Helicase_C IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3 IPR014001 Helicase_ATP-bd IPR027417 P-loop_NTPase |
Pfami | View protein in Pfam PF13307 Helicase_C_2, 1 hit |
SMARTi | View protein in SMART SM00487 DEXDc, 1 hit SM00491 HELICc2, 1 hit |
SUPFAMi | SSF52540 SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51193 HELICASE_ATP_BIND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DING_MYCTU | |
Accessioni | P9WMR5Primary (citable) accession number: P9WMR5 Secondary accession number(s): L0T6J2, P64314, Q10640 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | October 16, 2019 | |
This is version 29 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh
Mycobacterium tuberculosis strains ATCC 25618 / H37Rv and CDC 1551 / Oshkosh: entries and gene names