UniProtKB - P9WMR4 (DING_MYCTO)
Protein
Probable ATP-dependent helicase DinG homolog
Gene
dinG
Organism
Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
Status
Functioni
Probable helicase involved in DNA repair and perhaps also replication.By similarity
Catalytic activityi
- EC:3.6.4.12
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 49 – 56 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- DNA recombination Source: UniProtKB-KW
- DNA repair Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding, Helicase, Hydrolase |
Biological process | DNA damage, DNA recombination, DNA repair |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:dinG Ordered Locus Names:MT1371 |
Organismi | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Taxonomic identifieri | 83331 [NCBI] |
Taxonomic lineagei | Bacteria › Actinobacteria › Corynebacteriales › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000427256 | 1 – 664 | Probable ATP-dependent helicase DinG homologAdd BLAST | 664 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 290 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 277 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 246 – 249 | DEAH box | 4 |
Sequence similaritiesi
Phylogenomic databases
HOGENOMi | CLU_012117_2_0_11 |
Family and domain databases
InterProi | View protein in InterPro IPR006555, ATP-dep_Helicase_C IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3 IPR014001, Helicase_ATP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13307, Helicase_C_2, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00491, HELICc2, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51193, HELICASE_ATP_BIND_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P9WMR4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSESVSMSVP ELLAIAVAAL GGTRRRGQQE MAAAVAHAFE TGEHLVVQAG
60 70 80 90 100
TGTGKSLAYL VPAIIRALCD DAPVVVSTAT IALQRQLVDR DLPQLVDSLT
110 120 130 140 150
NALPRRPKFA LLKGRRNYLC LNKIHNSVTA SDHDDERPQE ELFDPVAVTA
160 170 180 190 200
LGRDVQRLTA WASTTVSGDR DDLKPGVGDR SWSQVSVSAR ECLGVARCPF
210 220 230 240 250
GSECFSERAR GAAGLADVVV TNHALLAIDA VAESAVLPEH RLLVVDEAHE
260 270 280 290 300
LADRVTSVAA AELTSATLGM AARRITRLVD PKVTQRLQAA SATFSSAIHD
310 320 330 340 350
ARPGRIDCLD DEMATYLSAL RDAASAARSA IDTGSDTTTA SVRAEAGAVL
360 370 380 390 400
TEISDTASRI LASFAPAIPD RSDVVWLEHE DNHESARAVL RVAPLSVAEL
410 420 430 440 450
LATQVFARAT TVLTSATLTI GGSFDAMATA WGLTADTPWR GLDVGSPFQH
460 470 480 490 500
AKSGILYVAA HLPPPGRDGS GSAEQLTEIA ELITAAGGRT LGLFSSMRAA
510 520 530 540 550
RAATEAMRER LSTPVLCQGD DSTSTLVEKF TADAATSLFG TLSLWQGVDV
560 570 580 590 600
PGPSLSLVLI DRIPFPRPDD PLLSARQRAV AARGGNGFMT VAASHAALLL
610 620 630 640 650
AQGSGRLLRR VTDRGVVAVL DSRMATARYG EFLRASLPPF WQTTNATQVR
660
AALRRLARAD AKAH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK45635.1 |
PIRi | E70770 |
RefSeqi | WP_003898827.1, NZ_KK341227.1 |
Genome annotation databases
EnsemblBacteriai | AAK45635; AAK45635; MT1371 |
GeneIDi | 23492517 |
KEGGi | mtc:MT1371 |
PATRICi | fig|83331.31.peg.1478 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE000516 Genomic DNA Translation: AAK45635.1 |
PIRi | E70770 |
RefSeqi | WP_003898827.1, NZ_KK341227.1 |
3D structure databases
SMRi | P9WMR4 |
ModBasei | Search... |
Genome annotation databases
EnsemblBacteriai | AAK45635; AAK45635; MT1371 |
GeneIDi | 23492517 |
KEGGi | mtc:MT1371 |
PATRICi | fig|83331.31.peg.1478 |
Phylogenomic databases
HOGENOMi | CLU_012117_2_0_11 |
Family and domain databases
InterProi | View protein in InterPro IPR006555, ATP-dep_Helicase_C IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3 IPR014001, Helicase_ATP-bd IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF13307, Helicase_C_2, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00491, HELICc2, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
PROSITEi | View protein in PROSITE PS51193, HELICASE_ATP_BIND_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DING_MYCTO | |
Accessioni | P9WMR4Primary (citable) accession number: P9WMR4 Secondary accession number(s): L0T6J2, P64314, Q10640 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 16, 2014 |
Last sequence update: | April 16, 2014 | |
Last modified: | December 2, 2020 | |
This is version 35 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |